Page last updated: 2024-10-30

leflunomide and Orthomyxoviridae Infections

leflunomide has been researched along with Orthomyxoviridae Infections in 2 studies

Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Orthomyxoviridae Infections: Virus diseases caused by the ORTHOMYXOVIRIDAE.

Research Excerpts

ExcerptRelevanceReference
" Leflunomide is an anti-inflammatory drug primarily used for treating rheumatoid arthritis (RA)."7.96A77 1726, the active metabolite of the anti-rheumatoid arthritis drug leflunomide, inhibits influenza A virus replication in vitro and in vivo by inhibiting the activity of Janus kinases. ( Hu, J; Liu, X; Peng, D; Prinz, RA; Sun, J; Wang, C; Wang, J; Xu, X, 2020)
" Leflunomide is an anti-inflammatory drug primarily used for treating rheumatoid arthritis (RA)."3.96A77 1726, the active metabolite of the anti-rheumatoid arthritis drug leflunomide, inhibits influenza A virus replication in vitro and in vivo by inhibiting the activity of Janus kinases. ( Hu, J; Liu, X; Peng, D; Prinz, RA; Sun, J; Wang, C; Wang, J; Xu, X, 2020)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's2 (100.00)2.80

Authors

AuthorsStudies
Wang, J1
Sun, J1
Hu, J1
Wang, C1
Prinz, RA1
Peng, D1
Liu, X1
Xu, X1
Xiong, R1
Zhang, L1
Li, S1
Sun, Y1
Ding, M1
Wang, Y1
Zhao, Y1
Wu, Y1
Shang, W1
Jiang, X1
Shan, J1
Shen, Z1
Tong, Y1
Xu, L1
Chen, Y1
Liu, Y1
Zou, G1
Lavillete, D1
Zhao, Z1
Wang, R1
Zhu, L1
Xiao, G1
Lan, K1
Li, H1
Xu, K1

Other Studies

2 other studies available for leflunomide and Orthomyxoviridae Infections

ArticleYear
A77 1726, the active metabolite of the anti-rheumatoid arthritis drug leflunomide, inhibits influenza A virus replication in vitro and in vivo by inhibiting the activity of Janus kinases.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020, Volume: 34, Issue:8

    Topics: A549 Cells; Aniline Compounds; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Line; Cell

2020
Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
    Protein & cell, 2020, Volume: 11, Issue:10

    Topics: Animals; Antiviral Agents; Betacoronavirus; Binding Sites; Cell Line; Coronavirus Infections; COVID-

2020