leflunomide has been researched along with Orthomyxoviridae Infections in 2 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Orthomyxoviridae Infections: Virus diseases caused by the ORTHOMYXOVIRIDAE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Leflunomide is an anti-inflammatory drug primarily used for treating rheumatoid arthritis (RA)." | 7.96 | A77 1726, the active metabolite of the anti-rheumatoid arthritis drug leflunomide, inhibits influenza A virus replication in vitro and in vivo by inhibiting the activity of Janus kinases. ( Hu, J; Liu, X; Peng, D; Prinz, RA; Sun, J; Wang, C; Wang, J; Xu, X, 2020) |
| " Leflunomide is an anti-inflammatory drug primarily used for treating rheumatoid arthritis (RA)." | 3.96 | A77 1726, the active metabolite of the anti-rheumatoid arthritis drug leflunomide, inhibits influenza A virus replication in vitro and in vivo by inhibiting the activity of Janus kinases. ( Hu, J; Liu, X; Peng, D; Prinz, RA; Sun, J; Wang, C; Wang, J; Xu, X, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, J | 1 |
| Sun, J | 1 |
| Hu, J | 1 |
| Wang, C | 1 |
| Prinz, RA | 1 |
| Peng, D | 1 |
| Liu, X | 1 |
| Xu, X | 1 |
| Xiong, R | 1 |
| Zhang, L | 1 |
| Li, S | 1 |
| Sun, Y | 1 |
| Ding, M | 1 |
| Wang, Y | 1 |
| Zhao, Y | 1 |
| Wu, Y | 1 |
| Shang, W | 1 |
| Jiang, X | 1 |
| Shan, J | 1 |
| Shen, Z | 1 |
| Tong, Y | 1 |
| Xu, L | 1 |
| Chen, Y | 1 |
| Liu, Y | 1 |
| Zou, G | 1 |
| Lavillete, D | 1 |
| Zhao, Z | 1 |
| Wang, R | 1 |
| Zhu, L | 1 |
| Xiao, G | 1 |
| Lan, K | 1 |
| Li, H | 1 |
| Xu, K | 1 |
2 other studies available for leflunomide and Orthomyxoviridae Infections
| Article | Year |
|---|---|
A77 1726, the active metabolite of the anti-rheumatoid arthritis drug leflunomide, inhibits influenza A virus replication in vitro and in vivo by inhibiting the activity of Janus kinases.
Topics: A549 Cells; Aniline Compounds; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Line; Cell | 2020 |
Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
Topics: Animals; Antiviral Agents; Betacoronavirus; Binding Sites; Cell Line; Coronavirus Infections; COVID- | 2020 |