leflunomide has been researched along with Nephrotic Syndrome in 7 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Nephrotic Syndrome: A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the safety and clinical efficacy of leflunomide (LEF) and prednisone on refractory nephrotic syndrome (RNS)." | 9.22 | Efficacy of leflunomide combined with prednisone in the treatment of refractory nephrotic syndrome. ( Chen, W; Liu, L; Liu, Y; Qu, X; Zhang, Y, 2016) |
| "To evaluate the therapeutic effects and safety of a combination therapy of leflunomide (LEF) and prednisone for the treatment of immunoglobulin A (IgA) nephropathy manifesting with nephrotic syndrome." | 9.14 | Comparison of the therapeutic effects of leflunomide and mycophenolate mofetil in the treatment of immunoglobulin A nephropathy manifesting with nephrotic syndrome. ( Li, DM; Liu, XW; Sun, SR; Xu, GS, 2010) |
| "To assess the safety and clinical efficacy of leflunomide (LEF) and prednisone on refractory nephrotic syndrome (RNS)." | 5.22 | Efficacy of leflunomide combined with prednisone in the treatment of refractory nephrotic syndrome. ( Chen, W; Liu, L; Liu, Y; Qu, X; Zhang, Y, 2016) |
| "To evaluate the therapeutic effects and safety of a combination therapy of leflunomide (LEF) and prednisone for the treatment of immunoglobulin A (IgA) nephropathy manifesting with nephrotic syndrome." | 5.14 | Comparison of the therapeutic effects of leflunomide and mycophenolate mofetil in the treatment of immunoglobulin A nephropathy manifesting with nephrotic syndrome. ( Li, DM; Liu, XW; Sun, SR; Xu, GS, 2010) |
| "Leflunomide (LEF)-induced interstitial lung disease (ILD) has been reported in patients with rheumatoid arthritis." | 1.37 | Interstitial lung diseases after leflunomide use in nephropathy: an analysis of reported cases in Chinese literature. ( Zhang, WX; Zhang, ZQ; Zhao, XW; Zhou, W, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, C | 1 |
| Cui, Z | 1 |
| Zhang, Y | 2 |
| Wang, F | 1 |
| Wang, X | 1 |
| Cheng, X | 1 |
| Meng, L | 1 |
| Liu, G | 1 |
| Zhao, M | 1 |
| Guo, Y | 1 |
| Wu, X | 1 |
| Liu, L | 2 |
| Zhang, H | 1 |
| Yang, L | 1 |
| Chen, W | 2 |
| Hu, WX | 1 |
| Chen, YH | 1 |
| Bao, H | 1 |
| Liu, ZZ | 1 |
| Wang, SF | 1 |
| Zhang, HT | 1 |
| Liu, ZH | 1 |
| Hodson, EM | 1 |
| Wong, SC | 1 |
| Willis, NS | 1 |
| Craig, JC | 1 |
| Liu, Y | 1 |
| Qu, X | 1 |
| Liu, XW | 1 |
| Li, DM | 1 |
| Xu, GS | 1 |
| Sun, SR | 1 |
| Zhang, WX | 1 |
| Zhou, W | 1 |
| Zhang, ZQ | 1 |
| Zhao, XW | 1 |
1 review available for leflunomide and Nephrotic Syndrome
| Article | Year |
|---|---|
Interventions for idiopathic steroid-resistant nephrotic syndrome in children.
Topics: Adolescent; Angiotensin-Converting Enzyme Inhibitors; Azathioprine; Child; Child, Preschool; Cycloph | 2016 |
3 trials available for leflunomide and Nephrotic Syndrome
| Article | Year |
|---|---|
Efficacy of leflunomide combined with prednisone for the treatment of PLA2R-associated primary membranous nephropathy.
Topics: Adult; Autoantibodies; Biomarkers; Cyclophosphamide; Drug Therapy, Combination; Female; Glomerulonep | 2020 |
Efficacy of leflunomide combined with prednisone in the treatment of refractory nephrotic syndrome.
Topics: Adolescent; Adult; China; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Immunosuppres | 2016 |
Comparison of the therapeutic effects of leflunomide and mycophenolate mofetil in the treatment of immunoglobulin A nephropathy manifesting with nephrotic syndrome.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Drug Therapy, Combination; Female; Glomerulonephritis, | 2010 |
3 other studies available for leflunomide and Nephrotic Syndrome
| Article | Year |
|---|---|
Leflunomide therapy for adult patients with steroid-dependent minimal change disease or primary focal segmental glomerulosclerosis.
Topics: Adult; Cyclosporine; Glomerulosclerosis, Focal Segmental; Humans; Leflunomide; Nephrosis, Lipoid; Ne | 2022 |
Glucocorticoid with or without additional immunosuppressant therapy for patients with lupus podocytopathy: a retrospective single-center study.
Topics: Adolescent; Adult; Azathioprine; Cyclophosphamide; Drug Therapy, Combination; Female; Follow-Up Stud | 2015 |
Interstitial lung diseases after leflunomide use in nephropathy: an analysis of reported cases in Chinese literature.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Child; China; Female; Humans; IgA Vasculitis; Isoxazo | 2011 |