leflunomide has been researched along with Multiple Organ Failure in 2 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Multiple Organ Failure: A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Wistar albino type rats were randomly divided into five groups: control, sham, leflunomide, sepsis, and sepsis + leflunomide." | 7.80 | Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis. ( Fadillioglu, E; Karaman, A; Ozturk, E; Samdancı, E; Surucu, M, 2014) |
| "Wistar albino type rats were randomly divided into five groups: control, sham, leflunomide, sepsis, and sepsis + leflunomide." | 3.80 | Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis. ( Fadillioglu, E; Karaman, A; Ozturk, E; Samdancı, E; Surucu, M, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ozturk, E | 1 |
| Surucu, M | 1 |
| Karaman, A | 1 |
| Samdancı, E | 1 |
| Fadillioglu, E | 1 |
| Miszewska-Szyszkowska, D | 1 |
| Mikołajczyk, N | 1 |
| Komuda-Leszek, E | 1 |
| Wieczorek-Godlewska, R | 1 |
| Świder, R | 1 |
| Dęborska-Materkowska, D | 1 |
| Szmidt, J | 1 |
| Durlik, M | 1 |
2 other studies available for leflunomide and Multiple Organ Failure
| Article | Year |
|---|---|
Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biomarkers; Catalase; Cecum; Disease | 2014 |
Severe cytomegalovirus infection in a second kidney transplant recipient treated with ganciclovir, leflunomide, and immunoglobulins, with complications including seizures, acute HCV infection, drug-induced pancytopenia, diabetes, cholangitis, and multi-or
Topics: Adult; Antiviral Agents; Cholangitis; Cytomegalovirus Infections; Diabetes Mellitus, Type 2; Fatal O | 2015 |