leflunomide has been researched along with Malignant Melanoma in 3 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study is a mechanistic validation of 'proof of concept' of effective topical delivery of leflunomide (LFD) nanoemulgel for localized efficient treatment of psoriatic lesions as well as melanoma affected skin regions." | 7.81 | Transcutaneous delivery of leflunomide nanoemulgel: Mechanistic investigation into physicomechanical characteristics, in vitro anti-psoriatic and anti-melanoma activity. ( Divate, D; Gangurde, S; Pawar, S; Pund, S, 2015) |
| "A novel role of the dihydroorotatedehydrogenase (DHODH) inhibitor leflunomide as a potential anti-melanoma therapy was recently reported (Nature 471:518-22, 2011)." | 7.78 | The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells. ( Jang, HS; Kerkvliet, NI; Koch, DC; Kolluri, SK; Kopparapu, PR; O'Donnell, EF; Phillips, JL; Tanguay, RL, 2012) |
| "The present study is a mechanistic validation of 'proof of concept' of effective topical delivery of leflunomide (LFD) nanoemulgel for localized efficient treatment of psoriatic lesions as well as melanoma affected skin regions." | 3.81 | Transcutaneous delivery of leflunomide nanoemulgel: Mechanistic investigation into physicomechanical characteristics, in vitro anti-psoriatic and anti-melanoma activity. ( Divate, D; Gangurde, S; Pawar, S; Pund, S, 2015) |
| "A novel role of the dihydroorotatedehydrogenase (DHODH) inhibitor leflunomide as a potential anti-melanoma therapy was recently reported (Nature 471:518-22, 2011)." | 3.78 | The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells. ( Jang, HS; Kerkvliet, NI; Koch, DC; Kolluri, SK; Kopparapu, PR; O'Donnell, EF; Phillips, JL; Tanguay, RL, 2012) |
| "Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest." | 1.37 | DHODH modulates transcriptional elongation in the neural crest and melanoma. ( Burke, CJ; Cech, J; Chen, F; Datta, S; Granter, S; Kaufman, C; Kramer, M; Langdon, E; Lin, CY; Long, HK; Morrison, S; Mosher, J; Neuberg, D; Rahl, PB; Ratanasirintrawoot, S; Tomlinson, ML; Wheeler, GN; White, RM; Young, RA; Zon, LI, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pund, S | 1 |
| Pawar, S | 1 |
| Gangurde, S | 1 |
| Divate, D | 1 |
| White, RM | 1 |
| Cech, J | 1 |
| Ratanasirintrawoot, S | 1 |
| Lin, CY | 1 |
| Rahl, PB | 1 |
| Burke, CJ | 1 |
| Langdon, E | 1 |
| Tomlinson, ML | 1 |
| Mosher, J | 1 |
| Kaufman, C | 1 |
| Chen, F | 1 |
| Long, HK | 1 |
| Kramer, M | 1 |
| Datta, S | 1 |
| Neuberg, D | 1 |
| Granter, S | 1 |
| Young, RA | 1 |
| Morrison, S | 1 |
| Wheeler, GN | 1 |
| Zon, LI | 1 |
| O'Donnell, EF | 1 |
| Kopparapu, PR | 1 |
| Koch, DC | 1 |
| Jang, HS | 1 |
| Phillips, JL | 1 |
| Tanguay, RL | 1 |
| Kerkvliet, NI | 1 |
| Kolluri, SK | 1 |
3 other studies available for leflunomide and Malignant Melanoma
| Article | Year |
|---|---|
Transcutaneous delivery of leflunomide nanoemulgel: Mechanistic investigation into physicomechanical characteristics, in vitro anti-psoriatic and anti-melanoma activity.
Topics: Adhesiveness; Administration, Cutaneous; Antineoplastic Agents; Cell Line, Tumor; Chemistry, Pharmac | 2015 |
DHODH modulates transcriptional elongation in the neural crest and melanoma.
Topics: Amino Acid Substitution; Animals; Animals, Genetically Modified; Cell Differentiation; Cell Line, Tu | 2011 |
The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells.
Topics: Aniline Compounds; Cell Line, Tumor; Cell Proliferation; Crotonates; Cyclin-Dependent Kinase Inhibit | 2012 |