leflunomide has been researched along with Lupus Erythematosus, Cutaneous in 13 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Lupus Erythematosus, Cutaneous: A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Teriflunomide, the active metabolite of leflunomide, is a disease-modifying therapy drug used for the treatment of multiple sclerosis (MS), yet the complications associated with this drug remain not fully understood." | 5.41 | Subacute cutaneous lupus erythematosus as a rare complication of disease-modifying therapy administration in multiple sclerosis: case report. ( Feng, J; Qin, X; Xu, K; Yang, S; Yu, G; Zhang, M; Zheng, P, 2023) |
| "Leflunomide is an immunosuppressive agent that acts by inhibiting pyrimidine synthesis in lymphocytes and other rapidly proliferating cells, as well as by suppressing tumor necrosis factor-alpha-induced cellular responses." | 5.35 | Leflunomide-induced subacute cutaneous lupus erythematosus with erythema multiforme-like lesions. ( Alessi, E; Barbareschi, M; Del Papa, N; Marzano, AV; Ramoni, S, 2008) |
| "A skin eruption consistent with subacute cutaneous lupus erythematosus (SCLE) occurred in a patient taking leflunomide for rheumatoid arthritis." | 3.73 | Subacute cutaneous lupus erythematosus associated with leflunomide. ( David-Bajar, KM; Elias, AR; Tam, CC, 2005) |
| "Leflunomide is an immunosuppressive agent that acts by inhibiting pyrimidine synthesis in lymphocytes and other rapidly proliferating cells, as well as by suppressing tumor necrosis factor-alpha-induced cellular responses." | 1.35 | Leflunomide-induced subacute cutaneous lupus erythematosus with erythema multiforme-like lesions. ( Alessi, E; Barbareschi, M; Del Papa, N; Marzano, AV; Ramoni, S, 2008) |
| "Leflunomide is a new oral disease modifying antirheumatic drug with a good safety profile." | 1.33 | Lupus erythematosus with leflunomide: induction or reactivation? ( Gensburger, D; Kanitakis, J; Kawashima, M; Marotte, H; Miossec, P, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (61.54) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, K | 1 |
| Zhang, M | 1 |
| Yang, S | 1 |
| Yu, G | 1 |
| Zheng, P | 1 |
| Qin, X | 1 |
| Feng, J | 1 |
| Blasco-Morente, G | 1 |
| Notario-Ferreira, I | 1 |
| Rueda-Villafranca, B | 1 |
| Tercedor-Sánchez, J | 1 |
| Sparsa, L | 1 |
| Afif, N | 1 |
| Goetz, J | 1 |
| Sordet, C | 1 |
| Chatelus, E | 1 |
| Lipsker, D | 1 |
| Sibilia, J | 1 |
| Kuhn, A | 1 |
| Ruland, V | 1 |
| Bonsmann, G | 1 |
| Kerr, OA | 1 |
| Murray, CS | 1 |
| Tidman, MJ | 1 |
| Heath, M | 1 |
| Raugi, GJ | 1 |
| Gensburger, D | 1 |
| Kawashima, M | 1 |
| Marotte, H | 1 |
| Kanitakis, J | 1 |
| Miossec, P | 1 |
| Goëb, V | 1 |
| Berthelot, JM | 1 |
| Joly, P | 1 |
| Mejjad, O | 1 |
| de Quatrebarbes, J | 1 |
| Reynaud-Hautin, C | 1 |
| Vittecoq, O | 1 |
| Le Loët, X | 1 |
| Chan, SK | 1 |
| Hazleman, BL | 1 |
| Burrows, NP | 1 |
| Elias, AR | 1 |
| Tam, CC | 1 |
| David-Bajar, KM | 1 |
| Suess, A | 1 |
| Sticherling, M | 1 |
| Marzano, AV | 1 |
| Ramoni, S | 1 |
| Del Papa, N | 1 |
| Barbareschi, M | 1 |
| Alessi, E | 1 |
3 reviews available for leflunomide and Lupus Erythematosus, Cutaneous
| Article | Year |
|---|---|
Subacute cutaneous lupus erythematosus as a rare complication of disease-modifying therapy administration in multiple sclerosis: case report.
Topics: Adult; Female; Humans; Hydroxychloroquine; Leflunomide; Lupus Erythematosus, Cutaneous; Multiple Scl | 2023 |
Cutaneous lupus erythematosus: update of therapeutic options part II.
Topics: Algorithms; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murin | 2011 |
Evidence-based evaluation of immunomodulatory therapy for the cutaneous manifestations of lupus.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antimalarials; Azathioprine; Cladrib | 2004 |
10 other studies available for leflunomide and Lupus Erythematosus, Cutaneous
| Article | Year |
|---|---|
Leflunomide: psoriasis, lupus.
Topics: Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lupus Erythematosus, Cutaneous; Psoriasis | 2013 |
[Subacute cutaneous lupus erythematosus induced by golimumab].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Eruptions; Drug Therapy, C | 2015 |
Jessner-Kanof disease induced by leflunomide: a dermal variant of cutaneous lupus?
Topics: Antibodies, Antinuclear; Antirheumatic Agents; Chloroquine; Female; Gold; Humans; Interleukin 1 Rece | 2011 |
Subacute cutaneous lupus erythematosus associated with leflunomide.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Eruptions; Humans; Isoxazoles; | 2004 |
Lupus erythematosus with leflunomide: induction or reactivation?
Topics: Antirheumatic Agents; Drug Eruptions; Female; Humans; Isoxazoles; Leflunomide; Lupus Erythematosus, | 2005 |
Leflunomide-induced subacute cutaneous lupus erythematosus.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Lupus Erythema | 2005 |
Subacute cutaneous lupus erythematosus precipitated by leflunomide.
Topics: Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lupus Erythematosus, Cutaneous; M | 2005 |
Subacute cutaneous lupus erythematosus associated with leflunomide.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunom | 2005 |
Leflunomide in subacute cutaneous lupus erythematosus - two sides of a coin.
Topics: Adult; Aged; Antirheumatic Agents; Diagnosis, Differential; Drug Eruptions; Enzyme Inhibitors; Eryth | 2008 |
Leflunomide-induced subacute cutaneous lupus erythematosus with erythema multiforme-like lesions.
Topics: Adjuvants, Immunologic; Adult; Antibodies, Antinuclear; Biopsy; Diagnosis, Differential; Erythema Mu | 2008 |