Page last updated: 2024-10-30

leflunomide and Lung Neoplasms

leflunomide has been researched along with Lung Neoplasms in 2 studies

Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Lung Neoplasms: Tumors or cancer of the LUNG.

Research Excerpts

ExcerptRelevanceReference
" Currently, SU101 in combination with cytotoxic agents is in late-stage clinical development for the treatment of cancers."1.31Effects of SU101 in combination with cytotoxic agents on the growth of subcutaneous tumor xenografts. ( Cherrington, JM; Kabbinavar, F; Mann, E; Schwartz, DP; Shawver, LK; Slamon, DJ; Strawn, LM, 2000)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Thomas, M1
Ponce-Aix, S1
Navarro, A1
Riera-Knorrenschild, J1
Schmidt, M1
Wiegert, E1
Kapp, K1
Wittig, B1
Mauri, C1
Dómine Gómez, M1
Kollmeier, J1
Sadjadian, P1
Fröhling, KP1
Huber, RM1
Wolf, M1
Strawn, LM1
Kabbinavar, F1
Schwartz, DP1
Mann, E1
Shawver, LK1
Slamon, DJ1
Cherrington, JM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Clinical Study of Maintenance Therapy With Immunomodulator MGN1703 in Patients With Extensive Disease Small Cell Lung Cancer After Platinum-Based First-Line Therapy[NCT02200081]Phase 2103 participants (Actual)Interventional2014-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for leflunomide and Lung Neoplasms

ArticleYear
Immunotherapeutic maintenance treatment with toll-like receptor 9 agonist lefitolimod in patients with extensive-stage small-cell lung cancer: results from the exploratory, controlled, randomized, international phase II IMPULSE study.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2018, 10-01, Volume: 29, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Cohort Studies; Etoposide; F

2018

Other Studies

1 other study available for leflunomide and Lung Neoplasms

ArticleYear
Effects of SU101 in combination with cytotoxic agents on the growth of subcutaneous tumor xenografts.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:7

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cell Div

2000