leflunomide has been researched along with Lung Diseases in 14 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Lung Diseases: Pathological processes involving any part of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the relative risk (RR) of pulmonary disease among patients with rheumatoid arthritis (RA) treated with leflunomide (LEF)." | 8.93 | Leflunomide Use and Risk of Lung Disease in Rheumatoid Arthritis: A Systematic Literature Review and Metaanalysis of Randomized Controlled Trials. ( Carey, JJ; Conway, R; Coughlan, RJ; Low, C; O'Donnell, MJ, 2016) |
| "Effectiveness of leflunomide renders it a potent treatment option in rheumatoid arthritis." | 8.87 | Update 2011: leflunomide in rheumatoid arthritis - strengths and weaknesses. ( Behrens, F; Burkhardt, H; Koehm, M, 2011) |
| "This study evaluated the efficiency of corticosteroid, leflunomide and mesenchymal stem cells (MSCs) in the treatment of pediatric idiopathic pulmonary hemosiderosis (IPH)." | 7.85 | Corticosteroid in Combination with Leflunomide and Mesenchymal Stem Cells for Treatment of Pediatric Idiopathic Pulmonary Hemosiderosis. ( Fang, JP; Ou, RQ; Tan, WP; Wang, HY; Wu, BJ; Xu, LH, 2017) |
| "We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset short-of-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide." | 7.74 | Diffuse alveolar hemorrhage after leflunomide therapy in a patient with rheumatoid arthritis. ( Carloni, A; Giannakakis, K; Nori, G; Piciucchi, S; Poletti, V; Zobel, BB, 2008) |
| "Rheumatoid nodules are well established manifestations of rheumatoid arthritis but in the lungs they are very rare according to the literature." | 5.35 | Intrapulmonary rheumatoid nodules in a patient with long-standing rheumatoid arthritis treated with leflunomide. ( Csiki, Z; Horvath, IF; Szanto, A; Szodoray, P; Zeher, M, 2008) |
| "To evaluate the relative risk (RR) of pulmonary disease among patients with rheumatoid arthritis (RA) treated with leflunomide (LEF)." | 4.93 | Leflunomide Use and Risk of Lung Disease in Rheumatoid Arthritis: A Systematic Literature Review and Metaanalysis of Randomized Controlled Trials. ( Carey, JJ; Conway, R; Coughlan, RJ; Low, C; O'Donnell, MJ, 2016) |
| "Effectiveness of leflunomide renders it a potent treatment option in rheumatoid arthritis." | 4.87 | Update 2011: leflunomide in rheumatoid arthritis - strengths and weaknesses. ( Behrens, F; Burkhardt, H; Koehm, M, 2011) |
| "We report the case of a 60 year female patient suffering from rheumatoid arthritis for the last 25 years, under TNF-blocker and leflunomide, affected by a recurrent pneumothorax with several subpleural nodules, basal bronchiectasis and apical bullous emphysema." | 4.85 | [Referring to an unusual case: pulmonary affection and rheumatoid arthritis]. ( Borges, H; Frey, JG; Schnyder, JM; Tschopp, JM, 2009) |
| "Treatment of rheumatoid arthritis (RA) has changed with the release of more efficient disease-modifying anti-inflammatory drugs (DMARDs) and biologicals, such as methotrexate, leflunomide and TNF blockers, respectively." | 4.82 | [Respiratory complications of new treatments for rheumatoid arthritis]. ( Lioté, H, 2004) |
| "This study evaluated the efficiency of corticosteroid, leflunomide and mesenchymal stem cells (MSCs) in the treatment of pediatric idiopathic pulmonary hemosiderosis (IPH)." | 3.85 | Corticosteroid in Combination with Leflunomide and Mesenchymal Stem Cells for Treatment of Pediatric Idiopathic Pulmonary Hemosiderosis. ( Fang, JP; Ou, RQ; Tan, WP; Wang, HY; Wu, BJ; Xu, LH, 2017) |
| "We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset short-of-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide." | 3.74 | Diffuse alveolar hemorrhage after leflunomide therapy in a patient with rheumatoid arthritis. ( Carloni, A; Giannakakis, K; Nori, G; Piciucchi, S; Poletti, V; Zobel, BB, 2008) |
| "Leflunomide (LEF) is indicated in adults for the treatment of active rheumatoid arthritis (RA)." | 3.73 | Rheumatoid lung nodulosis and osteopathy associated with leflunomide therapy. ( Balbir-Gurman, A; Guralnik, L; Keidar, Z; Nahir, AM; Rozenbaum, M; Rozin, A; Vlodavsky, E; Yigla, M, 2006) |
| "Rheumatoid nodules are well established manifestations of rheumatoid arthritis but in the lungs they are very rare according to the literature." | 1.35 | Intrapulmonary rheumatoid nodules in a patient with long-standing rheumatoid arthritis treated with leflunomide. ( Csiki, Z; Horvath, IF; Szanto, A; Szodoray, P; Zeher, M, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (57.14) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, H | 1 |
| Ou, R | 1 |
| Zhang, B | 1 |
| Li, S | 1 |
| Liu, Y | 1 |
| Tan, W | 1 |
| Winetsky, DE | 1 |
| Myers, J | 1 |
| Schulz, S | 1 |
| Tino, G | 1 |
| Wilck, M | 1 |
| Conway, R | 1 |
| Low, C | 1 |
| Coughlan, RJ | 1 |
| O'Donnell, MJ | 1 |
| Carey, JJ | 1 |
| Xu, LH | 1 |
| Ou, RQ | 1 |
| Wu, BJ | 1 |
| Wang, HY | 1 |
| Fang, JP | 1 |
| Tan, WP | 1 |
| Kelly, C | 1 |
| Borges, H | 1 |
| Schnyder, JM | 1 |
| Frey, JG | 1 |
| Tschopp, JM | 1 |
| Behrens, F | 1 |
| Koehm, M | 1 |
| Burkhardt, H | 1 |
| Suzuki, Y | 2 |
| Lioté, H | 1 |
| Rozin, A | 1 |
| Yigla, M | 1 |
| Guralnik, L | 1 |
| Keidar, Z | 1 |
| Vlodavsky, E | 1 |
| Rozenbaum, M | 1 |
| Nahir, AM | 1 |
| Balbir-Gurman, A | 1 |
| Balakrishnan, C | 1 |
| Dasgupta, B | 1 |
| Saito, E | 1 |
| Wakabayashi, T | 1 |
| Suwa, A | 1 |
| Carloni, A | 1 |
| Piciucchi, S | 1 |
| Giannakakis, K | 1 |
| Nori, G | 1 |
| Zobel, BB | 1 |
| Poletti, V | 1 |
| Horvath, IF | 1 |
| Szanto, A | 1 |
| Csiki, Z | 1 |
| Szodoray, P | 1 |
| Zeher, M | 1 |
5 reviews available for leflunomide and Lung Diseases
| Article | Year |
|---|---|
Leflunomide Use and Risk of Lung Disease in Rheumatoid Arthritis: A Systematic Literature Review and Metaanalysis of Randomized Controlled Trials.
Topics: Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lung Diseases; Ran | 2016 |
[Referring to an unusual case: pulmonary affection and rheumatoid arthritis].
Topics: Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchiectasis; Dyspnea; Female; | 2009 |
Update 2011: leflunomide in rheumatoid arthritis - strengths and weaknesses.
Topics: Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Rheuma | 2011 |
[Respiratory complications of new treatments for rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Lung Diseases; Methotr | 2004 |
[Adverse effects of conventional DMARDs and biologic DMARDs].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Chemical and Drug Induced Liver Injury; Cysteine; Drug | 2007 |
9 other studies available for leflunomide and Lung Diseases
| Article | Year |
|---|---|
Leflunomide Is Safe and Effective for the Induction and Maintenance of Idiopathic Pulmonary Hemosiderosis Remission.
Topics: Child; Glucocorticoids; Hemosiderosis; Humans; Leflunomide; Lung Diseases | 2023 |
A Case of Cavitary Pulmonary Mycobacterium Avium Intracellulare Infection in the Setting of Leflunomide Treatment.
Topics: Aged; Antitubercular Agents; Arthritis, Rheumatoid; Drug Monitoring; Drug Substitution; Female; Huma | 2017 |
Corticosteroid in Combination with Leflunomide and Mesenchymal Stem Cells for Treatment of Pediatric Idiopathic Pulmonary Hemosiderosis.
Topics: Adrenal Cortex Hormones; Child; Female; Glucocorticoids; Hemosiderosis; Hemosiderosis, Pulmonary; Hu | 2017 |
Leflunomide and the lung.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Lung Diseases | 2009 |
[Anti-rheumatic drugs].
Topics: Antirheumatic Agents; Cysteine; Hematologic Diseases; Humans; Hypersensitivity; Infections; Isoxazol | 2012 |
Rheumatoid lung nodulosis and osteopathy associated with leflunomide therapy.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Lung Diseases; M | 2006 |
Pulmonary adverse events with leflunomide--myth or reality?
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; L | 2007 |
Diffuse alveolar hemorrhage after leflunomide therapy in a patient with rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biopsy; Diagnosis, Differenti | 2008 |
Intrapulmonary rheumatoid nodules in a patient with long-standing rheumatoid arthritis treated with leflunomide.
Topics: Adult; Arthritis, Rheumatoid; Chronic Disease; Female; Humans; Isoxazoles; Leflunomide; Lung Disease | 2008 |