leflunomide has been researched along with Liver Dysfunction in 5 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spontaneous cases of hepatic adverse events have been reported in patients with rheumatoid arthritis who were being treated with leflunomide, one of the newer disease-modifying antirheumatic drugs (DMARDs)." | 3.72 | Newer disease-modifying antirheumatic drugs and the risk of serious hepatic adverse events in patients with rheumatoid arthritis. ( Bitton, A; Ernst, P; Hudson, M; Kezouh, A; Suissa, S, 2004) |
| "Leflunomide(Arava) is a novel immunomodulatory drug, the primary action of which is inhibition of de-novo pyrimidine synthesis by selective inhibition of dihydro-orotate dehydrogenase." | 2.41 | [Efficacy of leflunomide]. ( Hirohata, S, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakafero, G | 1 |
| Grainge, MJ | 1 |
| Card, T | 1 |
| Mallen, CD | 1 |
| Zhang, W | 1 |
| Doherty, M | 1 |
| Taal, MW | 1 |
| Aithal, GP | 1 |
| Abhishek, A | 1 |
| Karaman, A | 1 |
| Kirimlioglu, H | 1 |
| Tas, E | 1 |
| Karadag, N | 1 |
| Gülsul, C | 1 |
| Fadillioglu, E | 1 |
| Demircan, M | 1 |
| Hirohata, S | 1 |
| Yao, HW | 1 |
| Li, J | 1 |
| Jin, Y | 1 |
| Zhang, YF | 1 |
| Li, CY | 1 |
| Xu, SY | 1 |
| Suissa, S | 1 |
| Ernst, P | 1 |
| Hudson, M | 1 |
| Bitton, A | 1 |
| Kezouh, A | 1 |
1 review available for leflunomide and Liver Dysfunction
| Article | Year |
|---|---|
[Efficacy of leflunomide].
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Double-Bli | 2002 |
4 other studies available for leflunomide and Liver Dysfunction
| Article | Year |
|---|---|
What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?
Topics: Alanine Transaminase; Aspartate Aminotransferases; Biomarkers; Female; Humans; Immunosuppressive Age | 2021 |
Effect of leflunomide on liver regeneration after partial hepatectomy in rats.
Topics: Adjuvants, Immunologic; Animals; Catalase; Disease Models, Animal; Hepatectomy; Immunosuppressive Ag | 2010 |
Effect of leflunomide on immunological liver injury in mice.
Topics: Adjuvants, Immunologic; Animals; Isoxazoles; Leflunomide; Lipopolysaccharides; Liver Diseases; Male; | 2003 |
Newer disease-modifying antirheumatic drugs and the risk of serious hepatic adverse events in patients with rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; C | 2004 |