leflunomide has been researched along with Liver Cirrhosis in 6 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We identified silent liver fibrosis in patients with rheumatoid arthritis (RA) using transient elastography, and investigated medication that correlated with abnormal liver stiffness measurement (LSM) values." | 5.38 | Leflunomide increases the risk of silent liver fibrosis in patients with rheumatoid arthritis receiving methotrexate. ( Han, KH; Kim, BK; Kim, SU; Lee, SK; Lee, SW; Park, HJ; Park, YB, 2012) |
| " In the present study, the potential side effects of combination leflunomide and methotrexate (LEF+MTX), a conventional rheumatoid arthritis therapy used in the resolution of liver fibrosis, was investigated." | 3.91 | Combination leflunomide and methotrexate impedes the recovery of liver fibrosis, partly through inhibition of myeloid cell admittance. ( Guo, R; Ke, S; Lin, M; Su, Z; Zeng, D, 2019) |
| "We identified silent liver fibrosis in patients with rheumatoid arthritis (RA) using transient elastography, and investigated medication that correlated with abnormal liver stiffness measurement (LSM) values." | 1.38 | Leflunomide increases the risk of silent liver fibrosis in patients with rheumatoid arthritis receiving methotrexate. ( Han, KH; Kim, BK; Kim, SU; Lee, SK; Lee, SW; Park, HJ; Park, YB, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Barbarroja, N | 1 |
| Ruiz-Ponce, M | 1 |
| Cuesta-López, L | 1 |
| Pérez-Sánchez, C | 1 |
| López-Pedrera, C | 1 |
| Arias-de la Rosa, I | 1 |
| Collantes-Estévez, E | 1 |
| Lin, M | 1 |
| Guo, R | 1 |
| Su, Z | 1 |
| Ke, S | 1 |
| Zeng, D | 1 |
| Bilasy, SE | 1 |
| Essawy, SS | 1 |
| Mandour, MF | 1 |
| Ali, EA | 1 |
| Zaitone, SA | 1 |
| Tang, X | 1 |
| Yang, J | 1 |
| Li, J | 1 |
| Lee, SW | 1 |
| Park, HJ | 1 |
| Kim, BK | 1 |
| Han, KH | 1 |
| Lee, SK | 1 |
| Kim, SU | 1 |
| Park, YB | 1 |
| Weinblatt, ME | 1 |
| Dixon, JA | 1 |
| Falchuk, KR | 1 |
1 review available for leflunomide and Liver Cirrhosis
| Article | Year |
|---|---|
Nonalcoholic fatty liver disease in inflammatory arthritis: Relationship with cardiovascular risk.
Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Biological Products; Cardiovascular Diseases; Heart Dis | 2022 |
5 other studies available for leflunomide and Liver Cirrhosis
| Article | Year |
|---|---|
Combination leflunomide and methotrexate impedes the recovery of liver fibrosis, partly through inhibition of myeloid cell admittance.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Collagen Type III; Collagen Type IV; Disease M | 2019 |
Myelosuppressive and hepatotoxic potential of leflunomide and methotrexate combination in a rat model of rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood | 2015 |
Sensitization of human hepatic stellate cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by leflunomide.
Topics: Aniline Compounds; Apoptosis; Blotting, Western; Caspases; Cell Line; Crotonates; Hepatic Stellate C | 2009 |
Leflunomide increases the risk of silent liver fibrosis in patients with rheumatoid arthritis receiving methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Dose-Response Relationship, Dr | 2012 |
Serious liver disease in a patient receiving methotrexate and leflunomide.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; I | 2000 |