leflunomide has been researched along with Latent Tuberculosis in 2 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Latent Tuberculosis: The dormant form of TUBERCULOSIS where the person shows no obvious symptoms and no sign of the causative agent (Mycobacterium tuberculosis) in the SPUTUM despite being positive for tuberculosis infection skin test.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the multivariable model, the steroids dosage was a significant and independent predictor of negative ppd (p = 0." | 1.36 | Prevalence of positive ppd in a cohort of rheumatoid arthritis patients. ( Debonis, J; Mysler, E; Schijedman, A; Tamborenea, MN; Tate, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tamborenea, MN | 1 |
| Tate, G | 1 |
| Mysler, E | 1 |
| Debonis, J | 1 |
| Schijedman, A | 1 |
| Kwakernaak, AJ | 1 |
| Houtman, PM | 1 |
| Weel, JF | 1 |
| Spoorenberg, JP | 1 |
| Jansen, TL | 1 |
2 other studies available for leflunomide and Latent Tuberculosis
| Article | Year |
|---|---|
Prevalence of positive ppd in a cohort of rheumatoid arthritis patients.
Topics: Adult; Aged; Antirheumatic Agents; Argentina; Arthritis, Rheumatoid; Biological Products; Cross-Sect | 2010 |
A comparison of an interferon-gamma release assay and tuberculin skin test in refractory inflammatory disease patients screened for latent tuberculosis prior to the initiation of a first tumor necrosis factor α inhibitor.
Topics: Arthritis, Rheumatoid; Azathioprine; Biological Assay; CD4-Positive T-Lymphocytes; Female; Glucocort | 2011 |