leflunomide has been researched along with Kidney Failure in 11 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Kidney Failure: A severe irreversible decline in the ability of kidneys to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Leflunomide was selected as a last resort to avoid the nephrotoxicity of cidofovir." | 5.34 | Leflunomide failure to control recurrent cytomegalovirus infection in the setting of renal failure after allogeneic stem cell transplantation. ( Abdelhalim, A; Almyroudis, NG; Battiwalla, M; Becker, J; Elefante, A; McCarthy, A; McCarthy, PL; Paplham, P; Segal, BH; Smith, P, 2007) |
| " The present case control investigation was designed to evaluate the comparative toxicity of methotrexate and leflunomide on multiple organs in rheumatoid arthritis patients." | 4.31 | Comparative analysis of multiorgan toxicity induced by long term use of disease modifying anti-rheumatic drugs. ( Iqbal, MA; Mumtaz, T; Tahir, A; Tariq, MA, 2023) |
| "This analysis demonstrates for the first time that, used in a stepwise fashion, ciprofloxacin and leflunomide are effective and safe treatments for BK viremia in PRTR." | 3.80 | A novel treatment regimen for BK viremia. ( Cheam, H; Ettenger, RB; Malekzadeh, MH; Tsai, EW; Zaman, RA, 2014) |
| "Gender, age, and hypertension are associated with KD recurrence." | 1.43 | Clinicopathological features and prognosis of Kimura's disease with renal involvement in Chinese patients. ( Chen, Y; Liu, Z; Wang, J; Xu, F; Zeng, C, 2016) |
| "NC, with renal failure secondary to bilateral dysplastic kidneys, received an LRD renal transplant (tx) at 17 months of age." | 1.40 | Treatment of BK virus-associated nephropathy with CMX001 after kidney transplantation in a young child. ( Habib, S; Latiolais, LS; McClure, GB; Reisman, L; Vanchiere, JA, 2014) |
| "Leflunomide was selected as a last resort to avoid the nephrotoxicity of cidofovir." | 1.34 | Leflunomide failure to control recurrent cytomegalovirus infection in the setting of renal failure after allogeneic stem cell transplantation. ( Abdelhalim, A; Almyroudis, NG; Battiwalla, M; Becker, J; Elefante, A; McCarthy, A; McCarthy, PL; Paplham, P; Segal, BH; Smith, P, 2007) |
| "Leflunomide is an immune suppressive drug with anti viral activity in vitro and in animals." | 1.33 | Treatment of renal allograft polyoma BK virus infection with leflunomide. ( Atwood, W; Foster, P; Garfinkel, M; Gillen, D; Harland, R; Javaid, B; Jordan, J; Josephson, MA; Kadambi, P; Meehan, S; Millis, MJ; Sadhu, M; Thistlethwaite, RJ; Williams, J, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Mumtaz, T | 1 |
| Tahir, A | 1 |
| Tariq, MA | 1 |
| Iqbal, MA | 1 |
| Nakafero, G | 1 |
| Grainge, MJ | 1 |
| Card, T | 1 |
| Mallen, CD | 1 |
| Zhang, W | 1 |
| Doherty, M | 1 |
| Taal, MW | 1 |
| Aithal, GP | 1 |
| Abhishek, A | 1 |
| Zaman, RA | 1 |
| Ettenger, RB | 1 |
| Cheam, H | 1 |
| Malekzadeh, MH | 1 |
| Tsai, EW | 1 |
| Reisman, L | 1 |
| Habib, S | 1 |
| McClure, GB | 1 |
| Latiolais, LS | 1 |
| Vanchiere, JA | 1 |
| Chen, Y | 1 |
| Wang, J | 1 |
| Xu, F | 1 |
| Zeng, C | 1 |
| Liu, Z | 1 |
| Egli, A | 1 |
| Helmersen, DS | 1 |
| Taub, K | 1 |
| Hirsch, HH | 1 |
| Johnson, A | 1 |
| Sanders, JS | 1 |
| Riezebos-Brilman, A | 1 |
| Homan van der Heide, JJ | 1 |
| Bruyn, GA | 1 |
| Veenstra, RP | 1 |
| Halma, C | 1 |
| Grond, J | 1 |
| Josephson, MA | 1 |
| Gillen, D | 1 |
| Javaid, B | 1 |
| Kadambi, P | 1 |
| Meehan, S | 1 |
| Foster, P | 1 |
| Harland, R | 1 |
| Thistlethwaite, RJ | 1 |
| Garfinkel, M | 1 |
| Atwood, W | 1 |
| Jordan, J | 1 |
| Sadhu, M | 1 |
| Millis, MJ | 1 |
| Williams, J | 1 |
| Battiwalla, M | 1 |
| Paplham, P | 1 |
| Almyroudis, NG | 1 |
| McCarthy, A | 1 |
| Abdelhalim, A | 1 |
| Elefante, A | 1 |
| Smith, P | 1 |
| Becker, J | 1 |
| McCarthy, PL | 1 |
| Segal, BH | 1 |
| Mossad, SB | 1 |
| Avery, RK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| BK Viremia and BK Virus Nephropathy Post Kidney Transplant Comparison of New Practices With Traditional Approach: A Combined Retrospective Chart Review and Prospective Observational Study[NCT02758288] | 0 participants (Actual) | Observational | 2015-09-30 | Withdrawn | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 other studies available for leflunomide and Kidney Failure
| Article | Year |
|---|---|
Comparative analysis of multiorgan toxicity induced by long term use of disease modifying anti-rheumatic drugs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Creatinine; Humans; Leflunomide; Methotrexate; Renal In | 2023 |
What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?
Topics: Alanine Transaminase; Aspartate Aminotransferases; Biomarkers; Female; Humans; Immunosuppressive Age | 2021 |
A novel treatment regimen for BK viremia.
Topics: Adolescent; BK Virus; Child; Ciprofloxacin; Female; Fluoroquinolones; Glomerular Filtration Rate; Hu | 2014 |
Treatment of BK virus-associated nephropathy with CMX001 after kidney transplantation in a young child.
Topics: Administration, Oral; Biopsy; BK Virus; Child, Preschool; Ciprofloxacin; Creatinine; Cytosine; DNA, | 2014 |
Clinicopathological features and prognosis of Kimura's disease with renal involvement in Chinese patients.
Topics: Adolescent; Adult; Angiolymphoid Hyperplasia with Eosinophilia; Anti-Inflammatory Agents; China; Fem | 2016 |
Renal failure five years after lung transplantation due to polyomavirus BK-associated nephropathy.
Topics: Adult; Aged; Cidofovir; Cytosine; Female; Humans; Isoxazoles; Kidney Diseases; Leflunomide; Lung Tra | 2010 |
Progressive multifocal leuko-encephalopathy after ABO-incompatible kidney transplantation.
Topics: ABO Blood-Group System; Blood Group Incompatibility; Glomerulonephritis, IGA; Humans; Immunosuppress | 2012 |
Anti-glomerular basement membrane antibody-associated renal failure in a patient with leflunomide-treated rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Basement Membrane; Female; Humans; Immunocompromised Host; Immunosuppressive | 2003 |
Treatment of renal allograft polyoma BK virus infection with leflunomide.
Topics: Aniline Compounds; BK Virus; Blood; Cells, Cultured; Creatinine; Crotonates; Female; Humans; Hydroxy | 2006 |
Leflunomide failure to control recurrent cytomegalovirus infection in the setting of renal failure after allogeneic stem cell transplantation.
Topics: Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegalovirus Infections; Cytosine; Drug Therapy, Co | 2007 |
Second look at leflunomide "failure" to control cytomegalovirus infection in the setting of renal failure.
Topics: Antiviral Agents; Cytomegalovirus; Cytomegalovirus Infections; Humans; Isoxazoles; Leflunomide; Rena | 2007 |