leflunomide has been researched along with Kidney Diseases in 27 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report an unusual case of DRESS syndrome due to Leflunomide, also complicated by renal involvement in the form of granulomatous interstitial nephritis and vasculitis." | 8.89 | Leflunomide-induced DRESS syndrome with renal involvement and vasculitis. ( Dhir, V; Krishnan, S; Nada, R; Pinto, B, 2013) |
| " We report an unusual case of DRESS syndrome due to Leflunomide, also complicated by renal involvement in the form of granulomatous interstitial nephritis and vasculitis." | 4.89 | Leflunomide-induced DRESS syndrome with renal involvement and vasculitis. ( Dhir, V; Krishnan, S; Nada, R; Pinto, B, 2013) |
| " Patients with significant viremia and/or biopsy-proven BKPVAN were treated with immunosuppression reduction and leflunomide." | 3.85 | Stabilization of renal function after the first year of follow-up in kidney transplant recipients treated for significant BK polyomavirus infection or BK polyomavirus-associated nephropathy. ( Bodson-Clermont, P; Cardinal, H; Fortin, MC; Girardin, C; Hébert, MJ; Lévesque, R; Pâquet, MR; Renoult, E; Simard-Meilleur, MC; St-Louis, G, 2017) |
| "This small vessel vasculitis is characterised by palpable purpura, abdominal pain, arthritis or arthralgia and kidney involvement." | 3.01 | Interventions for preventing and treating kidney disease in IgA vasculitis. ( Craig, JC; Hahn, D; Hodson, EM, 2023) |
| "Leflunomide has shown promising results in BKVAN." | 2.66 | Leflunomide in the treatment of BK polyomavirus associated nephropathy in kidney transplanted patients - A systematic review. ( Dräger, DL; Hakenberg, OW; Kranz, J; Neumann, T; Schneidewind, L, 2020) |
| "Leflunomide is a synthetic isoxazole-derivative drug that possesses both immunosuppressive and antiviral properties." | 2.47 | Leflunomide in renal transplantation. ( Chon, WJ; Josephson, MA, 2011) |
| "New prospects for the treatment of vasculitis include novel immunosuppressive agents (e." | 2.41 | Novel therapies for anti-neutrophil cytoplasmic antibody-associated vasculitis. ( Kallenberg, CG; Stegeman, CA; Tervaert, JW, 2001) |
| "Treatment with leflunomide was started after a mean of 1." | 1.51 | Clinical utility of leflunomide for BK polyomavirus associated nephropathy in kidney transplant recipients: A multicenter retrospective study. ( Bouvier, N; Caillard, S; Conrad, A; Duquennoy, S; Fafi-Kremer, S; Hurault De Ligny, B; Keller, N; Morelon, E; Moulin, B, 2019) |
| " The dosage and time of therapy need to be explored in the future; additional studies of large samples are needed." | 1.42 | BK Virus-Associated Nephropathy with Plasma Cell-Rich Infiltrates Treated by Bortezomib-Based Regimen. ( Chen, JS; Cheng, DR; Ji, SM; Li, X; Liu, ZH; Wen, JQ; Wu, D; Xie, KN; Zhang, MC, 2015) |
| "Treatment with leflunomide reduced serum viral titres and stabilized renal function." | 1.38 | Native kidney BK virus nephropathy associated with chronic lymphocytic leukaemia. ( Gray, M; Leonard, N; McCrory, R; Smyth, J; Woodman, A, 2012) |
| "Current treatment of Kaposi's sarcoma is reduction of immunosuppression with or without addition of mammalian target of rapamycin inhibitors (mTORi)." | 1.37 | Leflunomide with low-dose everolimus for treatment of Kaposi's sarcoma in a renal allograft recipient. ( Basu, G; John, GT; Mani, SE; Manipadam, MT; Mohapatra, A, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 16 (59.26) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Hahn, D | 1 |
| Hodson, EM | 1 |
| Craig, JC | 1 |
| Kurašová, E | 1 |
| Štěpán, J | 1 |
| Krejčí, K | 1 |
| Mrázek, F | 1 |
| Sauer, P | 1 |
| Janečková, J | 1 |
| Tichý, T | 1 |
| Schneidewind, L | 1 |
| Neumann, T | 1 |
| Dräger, DL | 1 |
| Kranz, J | 1 |
| Hakenberg, OW | 1 |
| Keller, N | 1 |
| Duquennoy, S | 1 |
| Conrad, A | 1 |
| Fafi-Kremer, S | 1 |
| Morelon, E | 1 |
| Bouvier, N | 1 |
| Moulin, B | 1 |
| Hurault De Ligny, B | 1 |
| Caillard, S | 1 |
| Mutlu, D | 1 |
| Sağlık, I | 1 |
| Koyun, M | 1 |
| Comak, E | 1 |
| Mutlu, E | 1 |
| Uslu Gökçeoğlu, A | 1 |
| Cağla Doğan, S | 1 |
| Dinçkan, A | 1 |
| Akbaş, SH | 1 |
| Akkaya, B | 1 |
| Akman, S | 1 |
| Süleymanlar, G | 1 |
| Colak, D | 1 |
| Verhoeven, Y | 1 |
| Kemperman, H | 1 |
| Abrahams, AC | 1 |
| Wu, D | 1 |
| Zhang, MC | 1 |
| Chen, JS | 1 |
| Li, X | 1 |
| Cheng, DR | 1 |
| Xie, KN | 1 |
| Ji, SM | 1 |
| Liu, ZH | 1 |
| Wen, JQ | 1 |
| Lamarche, C | 1 |
| Boucher, A | 1 |
| Dandavino, R | 1 |
| Senécal, L | 1 |
| Collette, S | 1 |
| Tran, D | 1 |
| Vallée, M | 1 |
| Simard-Meilleur, MC | 1 |
| Bodson-Clermont, P | 1 |
| St-Louis, G | 1 |
| Pâquet, MR | 1 |
| Girardin, C | 1 |
| Fortin, MC | 1 |
| Cardinal, H | 1 |
| Hébert, MJ | 1 |
| Lévesque, R | 1 |
| Renoult, E | 1 |
| Wu, JK | 1 |
| Harris, MT | 1 |
| Bloudícková, S | 1 |
| Rajnoch, J | 1 |
| Lodererová, A | 1 |
| Honsová, E | 1 |
| Viklický, O | 1 |
| Egli, A | 1 |
| Helmersen, DS | 1 |
| Taub, K | 1 |
| Hirsch, HH | 2 |
| Johnson, A | 1 |
| Dheir, H | 1 |
| Sahin, S | 1 |
| Uyar, M | 1 |
| Gurkan, A | 1 |
| Turunc, V | 1 |
| Kacar, S | 1 |
| Bayirli Turan, D | 1 |
| Basdemir, G | 1 |
| Chon, WJ | 1 |
| Josephson, MA | 3 |
| Basu, G | 1 |
| Mohapatra, A | 1 |
| Manipadam, MT | 1 |
| Mani, SE | 1 |
| John, GT | 1 |
| McCrory, R | 1 |
| Gray, M | 1 |
| Leonard, N | 1 |
| Smyth, J | 1 |
| Woodman, A | 1 |
| Butts, RJ | 1 |
| Uber, WE | 1 |
| Savage, AJ | 1 |
| Suzuki, Y | 2 |
| Jung, YH | 1 |
| Moon, KC | 1 |
| Ha, JW | 1 |
| Kim, SJ | 1 |
| Ha, IS | 1 |
| Cheong, HI | 1 |
| Kang, HG | 1 |
| Pinto, B | 1 |
| Dhir, V | 1 |
| Krishnan, S | 1 |
| Nada, R | 1 |
| Williams, JW | 2 |
| Javaid, B | 1 |
| Kadambi, PV | 1 |
| Gillen, D | 1 |
| Harland, R | 1 |
| Thistlewaite, JR | 1 |
| Garfinkel, M | 1 |
| Foster, P | 1 |
| Atwood, W | 1 |
| Millis, JM | 1 |
| Meehan, SM | 1 |
| Sugii, S | 1 |
| Teschner, S | 1 |
| Geyer, M | 1 |
| Wilpert, J | 1 |
| Schwertfeger, E | 1 |
| Schenk, T | 1 |
| Walz, G | 1 |
| Donauer, J | 1 |
| Chandraker, A | 1 |
| Randhawa, PS | 1 |
| Faguer, S | 1 |
| Kamar, N | 1 |
| Guilbeau-Frugier, C | 1 |
| Ribes, D | 1 |
| Guitard, J | 1 |
| Esposito, L | 1 |
| Cointault, O | 1 |
| Modesto, A | 1 |
| Lavit, M | 1 |
| Mengelle, C | 1 |
| Rostaing, L | 1 |
| Saito, E | 1 |
| Wakabayashi, T | 1 |
| Suwa, A | 1 |
| Tervaert, JW | 1 |
| Stegeman, CA | 1 |
| Kallenberg, CG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| BK Viremia and BK Virus Nephropathy Post Kidney Transplant Comparison of New Practices With Traditional Approach: A Combined Retrospective Chart Review and Prospective Observational Study[NCT02758288] | 0 participants (Actual) | Observational | 2015-09-30 | Withdrawn | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for leflunomide and Kidney Diseases
| Article | Year |
|---|---|
Interventions for preventing and treating kidney disease in IgA vasculitis.
Topics: Adult; Child; Fosinopril; Humans; IgA Vasculitis; Kidney Diseases; Leflunomide; Proteinuria; Tacroli | 2023 |
Leflunomide in the treatment of BK polyomavirus associated nephropathy in kidney transplanted patients - A systematic review.
Topics: BK Virus; Humans; Kidney; Kidney Diseases; Leflunomide; Polyomavirus Infections; Tumor Virus Infecti | 2020 |
Use of leflunomide in the treatment of polyomavirus BK-associated nephropathy.
Topics: BK Virus; Humans; Isoxazoles; Kidney Diseases; Kidney Transplantation; Leflunomide; Polyomavirus Inf | 2008 |
Leflunomide in renal transplantation.
Topics: Humans; Immunosuppressive Agents; Isoxazoles; Kidney Diseases; Kidney Transplantation; Leflunomide | 2011 |
Leflunomide therapy for BK virus allograft nephropathy after pediatric kidney transplantation.
Topics: Antiviral Agents; BK Virus; Child; Female; Humans; Isoxazoles; Kidney Diseases; Kidney Transplantati | 2013 |
Leflunomide-induced DRESS syndrome with renal involvement and vasculitis.
Topics: Antirheumatic Agents; Biopsy; Drug Hypersensitivity Syndrome; Eosinophilia; Erythema; Exanthema; Hum | 2013 |
[Adverse effects of DMARDs in treatment of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Gold Sodium Thiomalate; Hematologic Diseases; H | 2005 |
Polyomavirus-associated nephropathy: update on antiviral strategies.
Topics: Animals; Antiviral Agents; Cidofovir; Cytosine; Humans; Isoxazoles; Kidney Diseases; Kidney Transpla | 2006 |
[Adverse effects of conventional DMARDs and biologic DMARDs].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Chemical and Drug Induced Liver Injury; Cysteine; Drug | 2007 |
Novel therapies for anti-neutrophil cytoplasmic antibody-associated vasculitis.
Topics: Antibodies, Antineutrophil Cytoplasmic; Antilymphocyte Serum; Cyclophosphamide; Guanidines; Humans; | 2001 |
17 other studies available for leflunomide and Kidney Diseases
| Article | Year |
|---|---|
Current Status, Prevention and Treatment of BK Virus Nephropathy.
Topics: BK Virus; Humans; Immunosuppressive Agents; Kidney Diseases; Kidney Transplantation; Leflunomide; Po | 2022 |
Clinical utility of leflunomide for BK polyomavirus associated nephropathy in kidney transplant recipients: A multicenter retrospective study.
Topics: Adult; Aged; Female; Graft Rejection; Humans; Immunosuppressive Agents; Kidney; Kidney Diseases; Kid | 2019 |
[BK virus infections in pediatric kidney transplant recipients].
Topics: Adolescent; Antiviral Agents; BK Virus; Child; Cidofovir; Cytosine; DNA, Viral; Female; Graft Reject | 2013 |
Falsely decreased ionized calcium levels in kidney transplant recipients with polyomavirus-associated nephropathy treated with leflunomide.
Topics: Aged; Antiviral Agents; Biomarkers; BK Virus; Calcium; Female; Humans; Immunocompromised Host; Isoxa | 2015 |
BK Virus-Associated Nephropathy with Plasma Cell-Rich Infiltrates Treated by Bortezomib-Based Regimen.
Topics: Adult; Antineoplastic Agents; BK Virus; Bortezomib; Female; Humans; Isoxazoles; Kidney Diseases; Kid | 2015 |
Treatment of Polyomavirus-Associated Nephropathy With the Association of Sirolimus and Leflunomide.
Topics: Antiviral Agents; Humans; Isoxazoles; Kidney Diseases; Kidney Transplantation; Leflunomide; Polyomav | 2015 |
Stabilization of renal function after the first year of follow-up in kidney transplant recipients treated for significant BK polyomavirus infection or BK polyomavirus-associated nephropathy.
Topics: Adult; Allografts; Antiviral Agents; Biopsy; BK Virus; DNA, Viral; Female; Follow-Up Studies; Glomer | 2017 |
Leflunomide derivate FK 778 in accelerated renal injury in transgenic rat.
Topics: Alkynes; Animals; Blood Pressure; Disease Models, Animal; Immunosuppressive Agents; Isoxazoles; Kidn | 2010 |
Renal failure five years after lung transplantation due to polyomavirus BK-associated nephropathy.
Topics: Adult; Aged; Cidofovir; Cytosine; Female; Humans; Isoxazoles; Kidney Diseases; Leflunomide; Lung Tra | 2010 |
Intensive polyoma virus nephropathy treatment as a preferable approach for graft surveillance.
Topics: Adult; Antiviral Agents; Cidofovir; Cytosine; Female; Graft Rejection; Graft Survival; Humans; Immun | 2011 |
Leflunomide with low-dose everolimus for treatment of Kaposi's sarcoma in a renal allograft recipient.
Topics: Antineoplastic Agents; Everolimus; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Diseases; Ki | 2011 |
Native kidney BK virus nephropathy associated with chronic lymphocytic leukaemia.
Topics: Aged; BK Virus; DNA, Viral; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Diseases; Leflunomi | 2012 |
Treatment of BK viremia in a pediatric heart transplant recipient.
Topics: Antiviral Agents; BK Virus; Child; Female; Graft Rejection; Heart Transplantation; Humans; Immunosup | 2012 |
[Anti-rheumatic drugs].
Topics: Antirheumatic Agents; Cysteine; Hematologic Diseases; Humans; Hypersensitivity; Infections; Isoxazol | 2012 |
Leflunomide for polyomavirus type BK nephropathy.
Topics: Aniline Compounds; Antiviral Agents; BK Virus; Crotonates; Humans; Hydroxybutyrates; Isoxazoles; Kid | 2005 |
Remission of polyomavirus-induced graft nephropathy treated with low-dose leflunomide.
Topics: Adult; Antiviral Agents; Humans; Immunoglobulins; Immunosuppressive Agents; Isoxazoles; Kidney Disea | 2006 |
Leflunomide treatment for polyomavirus BK-associated nephropathy after kidney transplantation.
Topics: Adult; Antiviral Agents; BK Virus; Female; Humans; Immunosuppression Therapy; Isoxazoles; Kidney Dis | 2007 |