leflunomide has been researched along with Interstitial Nephritis in 6 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experimental tubulointerstitial nephritis (TIN), induced in Brown Norway rats, is an autoimmune disorder in which afflicted animals display high levels of serum autoantibodies directed against antigens present on the tubular basement membrane (TBM)." | 5.28 | Leflunomide (HWA 486) inhibits experimental autoimmune tubulointerstitial nephritis in rats. ( Bartlett, RR; Langer, KH; Schleyerbach, R; Sitter, T; Thoenes, GH, 1989) |
| " The dosage of mycophenolate sodium was tapered from 720 to 360 mg daily and that of everolimus increased from 0." | 1.51 | Successful Treatment for BK Virus Nephropathy by Leflunomide in a Kidney Transplant Patient: A Case Report. ( Chen, HA; Chen, YW; Hsu, YH; Hung, LY; Lee, CH; Wu, MS; Wu, MY, 2019) |
| "Experimental tubulointerstitial nephritis (TIN), induced in Brown Norway rats, is an autoimmune disorder in which afflicted animals display high levels of serum autoantibodies directed against antigens present on the tubular basement membrane (TBM)." | 1.28 | Leflunomide (HWA 486) inhibits experimental autoimmune tubulointerstitial nephritis in rats. ( Bartlett, RR; Langer, KH; Schleyerbach, R; Sitter, T; Thoenes, GH, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Rasaei, N | 1 |
| Malekmakan, L | 1 |
| Gholamabbas, G | 1 |
| Abdizadeh, P | 1 |
| Chen, S | 1 |
| Yin, Q | 1 |
| Ren, S | 1 |
| Zhong, X | 1 |
| Wang, W | 1 |
| Li, G | 1 |
| Wang, L | 1 |
| Wu, MY | 1 |
| Chen, YW | 1 |
| Hung, LY | 1 |
| Lee, CH | 1 |
| Chen, HA | 1 |
| Hsu, YH | 1 |
| Wu, MS | 1 |
| Haydar, AA | 1 |
| Hujairi, N | 1 |
| Kirkham, B | 1 |
| Hangartner, R | 1 |
| Goldsmith, DJ | 1 |
| Ott, U | 1 |
| Steiner, T | 1 |
| Busch, M | 1 |
| Gerth, J | 1 |
| Wolf, G | 1 |
| Thoenes, GH | 1 |
| Sitter, T | 1 |
| Langer, KH | 1 |
| Bartlett, RR | 1 |
| Schleyerbach, R | 1 |
1 trial available for leflunomide and Interstitial Nephritis
| Article | Year |
|---|---|
Comparative Study of Intravenous Immunoglobulin and Leflunomide Combination Therapy With Intravenous Immunoglobulin Single Therapy in Kidney Transplant Patients With BK Virus Infection: Single-Center Clinical Trial.
Topics: Antiviral Agents; BK Virus; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Kidney T | 2023 |
5 other studies available for leflunomide and Interstitial Nephritis
| Article | Year |
|---|---|
A comparison of the effectiveness of cyclophosphamide, leflunomide, corticosteroids, or conservative management alone in patients with IgA nephropathy: a retrospective observational study.
Topics: Adrenal Cortex Hormones; Adult; Albuminuria; Angiotensin Receptor Antagonists; Angiotensin-Convertin | 2018 |
Successful Treatment for BK Virus Nephropathy by Leflunomide in a Kidney Transplant Patient: A Case Report.
Topics: BK Virus; Everolimus; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Kidney Trans | 2019 |
Chronic overdose of leflunomide inducing interstitial nephritis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Overdose; Humans; Isoxazo | 2004 |
A single-center experience with BK virus nephropathy.
Topics: Adult; Aged; Antiviral Agents; BK Virus; Cidofovir; Cytosine; Female; Graft Survival; Humans; Immuno | 2008 |
Leflunomide (HWA 486) inhibits experimental autoimmune tubulointerstitial nephritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoantibodies; Autoimmune Diseases; Basement Memb | 1989 |