leflunomide and Infection
leflunomide has been researched along with Infection in 7 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"To study the safety and efficacy of infliximab plus leflunomide combination therapy in adult rheumatoid arthritis (RA)." | 9.10 | Infliximab and leflunomide combination therapy in rheumatoid arthritis: an open-label study. ( Johnson, DM; Kiely, PD, 2002) |
"To compare infectious risk between leflunomide versus TNF inhibitors (TNFi), and between tacrolimus versus TNFi among rheumatoid arthritis (RA) patients receiving methotrexate (MTX)." | 8.12 | Infectious risk of add-on leflunomide or tacrolimus versus TNF inhibitors among patients with rheumatoid arthritis receiving background methotrexate: A population-based cohort study. ( Ha, YJ; Kang, EH; Lee, EB; Lee, JH; Lee, YJ; Shin, A, 2022) |
"To determine the prevalence of severe infections in patients with rheumatoid arthritis (RA) prescribed leflunomide in North Canterbury, New Zealand." | 7.74 | Leflunomide-associated infections in rheumatoid arthritis. ( Chapman, PT; Jenks, KA; O'Donnell, JL; Savage, RL; Stamp, LK, 2007) |
"To report the safety and efficacy of leflunomide (LEF) in combination with infliximab (INF) for the treatment of rheumatoid arthritis." | 7.72 | The safety and efficacy of leflunomide in combination with infliximab in rheumatoid arthritis. ( Cohen, S; Cooley, DA; Cush, J; Genovese, M; Hansen, KE; Patel, SR; Schiff, M; Singhal, A; Sundaramurthy, S, 2004) |
"To study the safety and efficacy of infliximab plus leflunomide combination therapy in adult rheumatoid arthritis (RA)." | 5.10 | Infliximab and leflunomide combination therapy in rheumatoid arthritis: an open-label study. ( Johnson, DM; Kiely, PD, 2002) |
"To compare infectious risk between leflunomide versus TNF inhibitors (TNFi), and between tacrolimus versus TNFi among rheumatoid arthritis (RA) patients receiving methotrexate (MTX)." | 4.12 | Infectious risk of add-on leflunomide or tacrolimus versus TNF inhibitors among patients with rheumatoid arthritis receiving background methotrexate: A population-based cohort study. ( Ha, YJ; Kang, EH; Lee, EB; Lee, JH; Lee, YJ; Shin, A, 2022) |
"To determine the prevalence of severe infections in patients with rheumatoid arthritis (RA) prescribed leflunomide in North Canterbury, New Zealand." | 3.74 | Leflunomide-associated infections in rheumatoid arthritis. ( Chapman, PT; Jenks, KA; O'Donnell, JL; Savage, RL; Stamp, LK, 2007) |
"To report the safety and efficacy of leflunomide (LEF) in combination with infliximab (INF) for the treatment of rheumatoid arthritis." | 3.72 | The safety and efficacy of leflunomide in combination with infliximab in rheumatoid arthritis. ( Cohen, S; Cooley, DA; Cush, J; Genovese, M; Hansen, KE; Patel, SR; Schiff, M; Singhal, A; Sundaramurthy, S, 2004) |
"The potential risk of infections related to conventional disease modifying anti-rheumatic drugs (DMARDs) is not completely clarified." | 2.44 | DMARDS and infections in rheumatoid arthritis. ( Bobbio-Pallavicini, F; Caporali, R; Caprioli, M; Montecucco, C, 2008) |
Research
Studies (7)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 4 (57.14) | 29.6817 |
2010's | 2 (28.57) | 24.3611 |
2020's | 1 (14.29) | 2.80 |
Authors
Authors | Studies |
---|---|
Shin, A | 1 |
Lee, JH | 1 |
Ha, YJ | 1 |
Lee, YJ | 1 |
Lee, EB | 1 |
Kang, EH | 1 |
Caporali, R | 1 |
Caprioli, M | 1 |
Bobbio-Pallavicini, F | 1 |
Montecucco, C | 1 |
Savage, RL | 2 |
Suzuki, Y | 1 |
Hansen, KE | 1 |
Cush, J | 1 |
Singhal, A | 1 |
Cooley, DA | 1 |
Cohen, S | 1 |
Patel, SR | 1 |
Genovese, M | 1 |
Sundaramurthy, S | 1 |
Schiff, M | 1 |
Jenks, KA | 1 |
Stamp, LK | 1 |
O'Donnell, JL | 1 |
Chapman, PT | 1 |
Kiely, PD | 1 |
Johnson, DM | 1 |
Reviews
1 review available for leflunomide and Infection
Article | Year |
---|---|
DMARDS and infections in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Infections; Isoxazoles; Leflunomide; Methotrexa | 2008 |
Trials
1 trial available for leflunomide and Infection
Article | Year |
---|---|
Infliximab and leflunomide combination therapy in rheumatoid arthritis: an open-label study.
Topics: Adult; Aged; Anaphylaxis; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoa | 2002 |
Other Studies
5 other studies available for leflunomide and Infection
Article | Year |
---|---|
Infectious risk of add-on leflunomide or tacrolimus versus TNF inhibitors among patients with rheumatoid arthritis receiving background methotrexate: A population-based cohort study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Herpes Zoster; Humans; Infections; Lefl | 2022 |
Leflunomide in combination therapy for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Australia; Drug Therapy, Combination; Humans; Infection | 2010 |
[Anti-rheumatic drugs].
Topics: Antirheumatic Agents; Cysteine; Hematologic Diseases; Humans; Hypersensitivity; Infections; Isoxazol | 2012 |
The safety and efficacy of leflunomide in combination with infliximab in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Ant | 2004 |
Leflunomide-associated infections in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cellulitis; Female; Hospitalization; Human | 2007 |