Page last updated: 2024-10-30

leflunomide and Infection

leflunomide has been researched along with Infection in 7 studies

Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Research Excerpts

ExcerptRelevanceReference
"To study the safety and efficacy of infliximab plus leflunomide combination therapy in adult rheumatoid arthritis (RA)."9.10Infliximab and leflunomide combination therapy in rheumatoid arthritis: an open-label study. ( Johnson, DM; Kiely, PD, 2002)
"To compare infectious risk between leflunomide versus TNF inhibitors (TNFi), and between tacrolimus versus TNFi among rheumatoid arthritis (RA) patients receiving methotrexate (MTX)."8.12Infectious risk of add-on leflunomide or tacrolimus versus TNF inhibitors among patients with rheumatoid arthritis receiving background methotrexate: A population-based cohort study. ( Ha, YJ; Kang, EH; Lee, EB; Lee, JH; Lee, YJ; Shin, A, 2022)
"To determine the prevalence of severe infections in patients with rheumatoid arthritis (RA) prescribed leflunomide in North Canterbury, New Zealand."7.74Leflunomide-associated infections in rheumatoid arthritis. ( Chapman, PT; Jenks, KA; O'Donnell, JL; Savage, RL; Stamp, LK, 2007)
"To report the safety and efficacy of leflunomide (LEF) in combination with infliximab (INF) for the treatment of rheumatoid arthritis."7.72The safety and efficacy of leflunomide in combination with infliximab in rheumatoid arthritis. ( Cohen, S; Cooley, DA; Cush, J; Genovese, M; Hansen, KE; Patel, SR; Schiff, M; Singhal, A; Sundaramurthy, S, 2004)
"To study the safety and efficacy of infliximab plus leflunomide combination therapy in adult rheumatoid arthritis (RA)."5.10Infliximab and leflunomide combination therapy in rheumatoid arthritis: an open-label study. ( Johnson, DM; Kiely, PD, 2002)
"To compare infectious risk between leflunomide versus TNF inhibitors (TNFi), and between tacrolimus versus TNFi among rheumatoid arthritis (RA) patients receiving methotrexate (MTX)."4.12Infectious risk of add-on leflunomide or tacrolimus versus TNF inhibitors among patients with rheumatoid arthritis receiving background methotrexate: A population-based cohort study. ( Ha, YJ; Kang, EH; Lee, EB; Lee, JH; Lee, YJ; Shin, A, 2022)
"To determine the prevalence of severe infections in patients with rheumatoid arthritis (RA) prescribed leflunomide in North Canterbury, New Zealand."3.74Leflunomide-associated infections in rheumatoid arthritis. ( Chapman, PT; Jenks, KA; O'Donnell, JL; Savage, RL; Stamp, LK, 2007)
"To report the safety and efficacy of leflunomide (LEF) in combination with infliximab (INF) for the treatment of rheumatoid arthritis."3.72The safety and efficacy of leflunomide in combination with infliximab in rheumatoid arthritis. ( Cohen, S; Cooley, DA; Cush, J; Genovese, M; Hansen, KE; Patel, SR; Schiff, M; Singhal, A; Sundaramurthy, S, 2004)
"The potential risk of infections related to conventional disease modifying anti-rheumatic drugs (DMARDs) is not completely clarified."2.44DMARDS and infections in rheumatoid arthritis. ( Bobbio-Pallavicini, F; Caporali, R; Caprioli, M; Montecucco, C, 2008)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's2 (28.57)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Shin, A1
Lee, JH1
Ha, YJ1
Lee, YJ1
Lee, EB1
Kang, EH1
Caporali, R1
Caprioli, M1
Bobbio-Pallavicini, F1
Montecucco, C1
Savage, RL2
Suzuki, Y1
Hansen, KE1
Cush, J1
Singhal, A1
Cooley, DA1
Cohen, S1
Patel, SR1
Genovese, M1
Sundaramurthy, S1
Schiff, M1
Jenks, KA1
Stamp, LK1
O'Donnell, JL1
Chapman, PT1
Kiely, PD1
Johnson, DM1

Reviews

1 review available for leflunomide and Infection

ArticleYear
DMARDS and infections in rheumatoid arthritis.
    Autoimmunity reviews, 2008, Volume: 8, Issue:2

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Infections; Isoxazoles; Leflunomide; Methotrexa

2008

Trials

1 trial available for leflunomide and Infection

ArticleYear
Infliximab and leflunomide combination therapy in rheumatoid arthritis: an open-label study.
    Rheumatology (Oxford, England), 2002, Volume: 41, Issue:6

    Topics: Adult; Aged; Anaphylaxis; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoa

2002

Other Studies

5 other studies available for leflunomide and Infection

ArticleYear
Infectious risk of add-on leflunomide or tacrolimus versus TNF inhibitors among patients with rheumatoid arthritis receiving background methotrexate: A population-based cohort study.
    Seminars in arthritis and rheumatism, 2022, Volume: 55

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Herpes Zoster; Humans; Infections; Lefl

2022
Leflunomide in combination therapy for rheumatoid arthritis.
    Drug safety, 2010, Jun-01, Volume: 33, Issue:6

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Australia; Drug Therapy, Combination; Humans; Infection

2010
[Anti-rheumatic drugs].
    Nihon rinsho. Japanese journal of clinical medicine, 2012, Volume: 70 Suppl 6

    Topics: Antirheumatic Agents; Cysteine; Hematologic Diseases; Humans; Hypersensitivity; Infections; Isoxazol

2012
The safety and efficacy of leflunomide in combination with infliximab in rheumatoid arthritis.
    Arthritis and rheumatism, 2004, Apr-15, Volume: 51, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Ant

2004
Leflunomide-associated infections in rheumatoid arthritis.
    The Journal of rheumatology, 2007, Volume: 34, Issue:11

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cellulitis; Female; Hospitalization; Human

2007
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