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leflunomide and Hepatocellular Carcinoma

leflunomide has been researched along with Hepatocellular Carcinoma in 3 studies

Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Research Excerpts

ExcerptRelevanceReference
"Treatment with leflunomide, perindopril or curcumin alone abrogated the DEN-induced increased MVD as well as the elevated expression of VEGF, while only curcumin inhibited HIF-1α hepatic expression."5.40Targeting different angiogenic pathways with combination of curcumin, leflunomide and perindopril inhibits diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Hamed, O; Kazem, A; Nasr, M; Selima, E, 2014)
"Treatment with leflunomide, perindopril or curcumin alone abrogated the DEN-induced increased MVD as well as the elevated expression of VEGF, while only curcumin inhibited HIF-1α hepatic expression."1.40Targeting different angiogenic pathways with combination of curcumin, leflunomide and perindopril inhibits diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Hamed, O; Kazem, A; Nasr, M; Selima, E, 2014)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Abdel-Hamid, NM1
Abass, SA1
Eldomany, RA1
Abdel-Kareem, MA1
Zakaria, S1
Nasr, M1
Selima, E1
Hamed, O1
Kazem, A1
Casadio, F1
Croci, S1
D'Errico Grigioni, A1
Corti, B1
Grigioni, WF1
Landuzzi, L1
Lollini, PL1

Other Studies

3 other studies available for leflunomide and Hepatocellular Carcinoma

ArticleYear
Dual regulating of mitochondrial fusion and Timp-3 by leflunomide and diallyl disulfide combination suppresses diethylnitrosamine-induced hepatocellular tumorigenesis in rats.
    Life sciences, 2022, Apr-01, Volume: 294

    Topics: Alkylating Agents; Allyl Compounds; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Dieth

2022
Targeting different angiogenic pathways with combination of curcumin, leflunomide and perindopril inhibits diethylnitrosamine-induced hepatocellular carcinoma in mice.
    European journal of pharmacology, 2014, Jan-15, Volume: 723

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antineoplastic Agents; Antirheumatic Agents; Carc

2014
Toward the definition of immunosuppressive regimens with antitumor activity.
    Transplantation proceedings, 2005, Volume: 37, Issue:5

    Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Survival; Colore

2005