leflunomide has been researched along with Hepatitis in 4 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Hepatitis: INFLAMMATION of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Leflunomide can inhibit hepatocyte damage by inhibiting proinflammatory cytokine release from KCs." | 1.32 | Leflunomide attenuates hepatocyte injury by inhibiting Kupffer cells. ( Chen, JQ; Li, J; Xu, SY; Yao, HW, 2004) |
| "Treatment with leflunomide markedly reduced serum transaminase activities and the numbers of dead liver cells." | 1.32 | Leflunomide protects from T-cell-mediated liver injury in mice through inhibition of nuclear factor kappaB. ( Asano, T; Hayashi, H; Imao, M; Imose, M; Kimura, K; Moriwaki, H; Nagaki, M; Naiki, T; Osawa, Y; Takai, S, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vieira, FJ | 1 |
| Callado, MR | 1 |
| Vieira, WP | 1 |
| Yao, HW | 2 |
| Li, J | 2 |
| Chen, JQ | 2 |
| Xu, SY | 2 |
| Imose, M | 1 |
| Nagaki, M | 1 |
| Kimura, K | 1 |
| Takai, S | 1 |
| Imao, M | 1 |
| Naiki, T | 1 |
| Osawa, Y | 1 |
| Asano, T | 1 |
| Hayashi, H | 1 |
| Moriwaki, H | 1 |
4 other studies available for leflunomide and Hepatitis
| Article | Year |
|---|---|
Abatacept as an option therapy in difficult to treat psoriatic arthritis.
Topics: Abatacept; Arthritis, Psoriatic; Drug Administration Schedule; Drug Resistance; Female; Hepatitis; H | 2010 |
Leflunomide attenuates hepatocyte injury by inhibiting Kupffer cells.
Topics: Aniline Compounds; Animals; Cell Communication; Cells, Cultured; Crotonates; Hepatitis; Hepatocytes; | 2004 |
A 771726, the active metabolite of leflunomide, inhibits TNF-alpha and IL-1 from Kupffer cells.
Topics: Aniline Compounds; Animals; Cell Communication; Cell Survival; Cells, Cultured; Coculture Techniques | 2004 |
Leflunomide protects from T-cell-mediated liver injury in mice through inhibition of nuclear factor kappaB.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase Inhibitors; Cells, Cultured; Concanavalin | 2004 |