Page last updated: 2024-10-30

leflunomide and Headache

leflunomide has been researched along with Headache in 2 studies

Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Headache: The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"Leflunomide is effective and well tolerated in the treatment of rheumatoid arthritis (RA), however, data on its use in early RA are scarce."9.14Leflunomide in the treatment of patients with early rheumatoid arthritis--results of a prospective non-interventional study. ( Bornholdt, K; Hein, G; Kellner, H, 2010)
"Leflunomide is effective and well tolerated in the treatment of rheumatoid arthritis (RA), however, data on its use in early RA are scarce."5.14Leflunomide in the treatment of patients with early rheumatoid arthritis--results of a prospective non-interventional study. ( Bornholdt, K; Hein, G; Kellner, H, 2010)
" Treatment was well tolerated; numbers of adverse events and serious adverse events were similar in all treatment groups."2.72A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. ( Bar-Or, A; Confavreux, C; Freedman, MS; Li, D; O'Connor, PW; Paty, DW; Rice, GP; Scheyer, R; Stewart, JA, 2006)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kellner, H1
Bornholdt, K1
Hein, G1
O'Connor, PW1
Li, D1
Freedman, MS1
Bar-Or, A1
Rice, GP1
Confavreux, C1
Paty, DW1
Stewart, JA1
Scheyer, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase II Study of the Safety and Efficacy of Teriflunomide (HMR1726) in Multiple Sclerosis With Relapses[NCT01487096]Phase 2179 participants (Actual)Interventional2001-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for leflunomide and Headache

ArticleYear
Leflunomide in the treatment of patients with early rheumatoid arthritis--results of a prospective non-interventional study.
    Clinical rheumatology, 2010, Volume: 29, Issue:8

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood Sedimentation; Di

2010
A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses.
    Neurology, 2006, Mar-28, Volume: 66, Issue:6

    Topics: Adult; Double-Blind Method; Female; Headache; Humans; Immunologic Factors; Isoxazoles; Leflunomide;

2006