leflunomide has been researched along with Headache in 2 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Headache: The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.
Excerpt | Relevance | Reference |
---|---|---|
"Leflunomide is effective and well tolerated in the treatment of rheumatoid arthritis (RA), however, data on its use in early RA are scarce." | 9.14 | Leflunomide in the treatment of patients with early rheumatoid arthritis--results of a prospective non-interventional study. ( Bornholdt, K; Hein, G; Kellner, H, 2010) |
"Leflunomide is effective and well tolerated in the treatment of rheumatoid arthritis (RA), however, data on its use in early RA are scarce." | 5.14 | Leflunomide in the treatment of patients with early rheumatoid arthritis--results of a prospective non-interventional study. ( Bornholdt, K; Hein, G; Kellner, H, 2010) |
" Treatment was well tolerated; numbers of adverse events and serious adverse events were similar in all treatment groups." | 2.72 | A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. ( Bar-Or, A; Confavreux, C; Freedman, MS; Li, D; O'Connor, PW; Paty, DW; Rice, GP; Scheyer, R; Stewart, JA, 2006) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (50.00) | 29.6817 |
2010's | 1 (50.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Kellner, H | 1 |
Bornholdt, K | 1 |
Hein, G | 1 |
O'Connor, PW | 1 |
Li, D | 1 |
Freedman, MS | 1 |
Bar-Or, A | 1 |
Rice, GP | 1 |
Confavreux, C | 1 |
Paty, DW | 1 |
Stewart, JA | 1 |
Scheyer, R | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Phase II Study of the Safety and Efficacy of Teriflunomide (HMR1726) in Multiple Sclerosis With Relapses[NCT01487096] | Phase 2 | 179 participants (Actual) | Interventional | 2001-04-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
2 trials available for leflunomide and Headache
Article | Year |
---|---|
Leflunomide in the treatment of patients with early rheumatoid arthritis--results of a prospective non-interventional study.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood Sedimentation; Di | 2010 |
A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses.
Topics: Adult; Double-Blind Method; Female; Headache; Humans; Immunologic Factors; Isoxazoles; Leflunomide; | 2006 |