leflunomide has been researched along with HIV Coinfection in 3 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Leflunomide has been shown to possess antiviral activity against several viruses." | 5.38 | Successful treatment of acyclovir-resistant herpes simplex virus type 2 proctitis with leflunomide in an HIV-infected man. ( Henao-Martínez, AF; Levi, ME; Waldman, WJ; Weinberg, A, 2012) |
| "Treatment with leflunomide was well tolerated with mostly low-grade adverse events." | 2.75 | The effect of leflunomide on cycling and activation of T-cells in HIV-1-infected participants. ( Adelsberger, JW; Ciccone, EJ; DeGrezia, M; DerSimonian, R; Higgins, J; Read, SW; Rehm, C; Sereti, I; Starling, JM, 2010) |
| "Leflunomide has been shown to possess antiviral activity against several viruses." | 1.38 | Successful treatment of acyclovir-resistant herpes simplex virus type 2 proctitis with leflunomide in an HIV-infected man. ( Henao-Martínez, AF; Levi, ME; Waldman, WJ; Weinberg, A, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Alfano, G | 1 |
| Fontana, F | 1 |
| Guaraldi, G | 1 |
| Cappelli, G | 1 |
| Mussini, C | 1 |
| Read, SW | 1 |
| DeGrezia, M | 1 |
| Ciccone, EJ | 1 |
| DerSimonian, R | 1 |
| Higgins, J | 1 |
| Adelsberger, JW | 1 |
| Starling, JM | 1 |
| Rehm, C | 1 |
| Sereti, I | 1 |
| Henao-Martínez, AF | 1 |
| Weinberg, A | 1 |
| Waldman, WJ | 1 |
| Levi, ME | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Effect of Leflunomide on HIV-1 Associated Immune Proliferation In Vivo[NCT00101374] | Phase 1 | 41 participants (Actual) | Interventional | 2005-01-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for leflunomide and HIV Coinfection
| Article | Year |
|---|---|
The effect of leflunomide on cycling and activation of T-cells in HIV-1-infected participants.
Topics: Adult; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Drug-Related Side Effects and Adverse | 2010 |
2 other studies available for leflunomide and HIV Coinfection
| Article | Year |
|---|---|
Successful treatment of BK virus associated-nephropathy in a human immunodeficiency virus-positive kidney transplant recipient.
Topics: AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; BK Virus; CD4 Lymphocy | 2020 |
Successful treatment of acyclovir-resistant herpes simplex virus type 2 proctitis with leflunomide in an HIV-infected man.
Topics: Acyclovir; Adult; Antiviral Agents; Drug Resistance, Viral; Herpes Genitalis; Herpesvirus 2, Human; | 2012 |