Page last updated: 2024-10-30

leflunomide and Granulomatosis, Wegener's

leflunomide has been researched along with Granulomatosis, Wegener's in 8 studies

Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Research Excerpts

ExcerptRelevanceReference
"LEF at a dosage of 30 mg/day appears to be effective in the prevention of major relapses in WG, however, this is associated with an increased frequency of adverse events."2.73Elevated relapse rate under oral methotrexate versus leflunomide for maintenance of remission in Wegener's granulomatosis. ( de Groot, K; Gross, WL; Hellmich, B; Iking-Konert, C; Manger, K; Metzler, C; Miehle, N; Reinhold-Keller, E, 2007)
"Leflunomide treatment was initiated at 20 mg/day and increased to 30 mg/day after 12 weeks and, in patients with partial remission, to 40 mg/day after 24 weeks."2.71Maintenance of remission with leflunomide in Wegener's granulomatosis. ( Fink, C; Gross, WL; Lamprecht, P; Metzler, C; Reinhold-Keller, E, 2004)
"In the past, recommendations for the treatment of Wegener's granulomatosis were primarily based on findings reported from open-label clinical trials."2.43Advances in the therapy of Wegener's granulomatosis. ( Gross, WL; Hellmich, B; Lamprecht, P, 2006)
"Extensive Wegener's granulomatosis (WG) is treated by glucocorticosteroids (GC) and cyclophosphamide (CYC)."1.34Rituximab for treatment-resistant extensive Wegener's granulomatosis--additive effects of a maintenance treatment with leflunomide. ( Fritz, J; Henes, JC; Horger, M; Kanz, L; Klein, R; Koch, S; Koetter, I; Risler, T, 2007)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (75.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lee, JJY1
Alsaleem, A1
Chiang, GPK1
Limenis, E1
Sontichai, W1
Yeung, RSM1
Akikusa, J1
Laxer, RM1
Henes, JC2
Kanz, L2
Koetter, I2
Reinhold-Keller, E3
Metzler, C2
Fink, C1
Lamprecht, P2
Gross, WL3
Hellmich, B2
Jayne, D1
Fritz, J1
Koch, S1
Klein, R1
Horger, M1
Risler, T1
Miehle, N1
Manger, K1
Iking-Konert, C1
de Groot, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multicenter Randomized Placebo Controlled Treatment Study of Leflunomide in Polymyalgia Rheumatica[NCT03576794]Phase 394 participants (Anticipated)Interventional2019-03-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for leflunomide and Granulomatosis, Wegener's

ArticleYear
Hallmark trials in ANCA-associated vasculitis (AAV) for the pediatric rheumatologist.
    Pediatric rheumatology online journal, 2019, Jun-26, Volume: 17, Issue:1

    Topics: Adult; Anti-Inflammatory Agents; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Azathio

2019
Advances in the therapy of Wegener's granulomatosis.
    Current opinion in rheumatology, 2006, Volume: 18, Issue:1

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Azathioprine; Cyclophosphamide; Etan

2006

Trials

2 trials available for leflunomide and Granulomatosis, Wegener's

ArticleYear
Maintenance of remission with leflunomide in Wegener's granulomatosis.
    Rheumatology (Oxford, England), 2004, Volume: 43, Issue:3

    Topics: Adult; Aged; Antirheumatic Agents; Drug Therapy, Combination; Female; Glucocorticoids; Granulomatosi

2004
Elevated relapse rate under oral methotrexate versus leflunomide for maintenance of remission in Wegener's granulomatosis.
    Rheumatology (Oxford, England), 2007, Volume: 46, Issue:7

    Topics: Administration, Oral; Adult; Aged; Antibodies, Antineutrophil Cytoplasmic; C-Reactive Protein; Cyclo

2007

Other Studies

4 other studies available for leflunomide and Granulomatosis, Wegener's

ArticleYear
Rituximab and leflunomide for Wegener's granulomatosis: a long-term follow-up.
    Rheumatology international, 2011, Volume: 31, Issue:3

    Topics: Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Follow-Up Studies; Granulomatosis with

2011
[How long should cyclophosphamide therapy of Wegener's granulomatosis continue?].
    Deutsche medizinische Wochenschrift (1946), 2002, Sep-13, Volume: 127, Issue:37

    Topics: Adjuvants, Immunologic; Administration, Oral; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-

2002
Leflunomide versus methotrexate in Wegener's granulomatosis.
    Rheumatology (Oxford, England), 2007, Volume: 46, Issue:7

    Topics: Glucocorticoids; Granulomatosis with Polyangiitis; Humans; Immunosuppressive Agents; Isoxazoles; Lef

2007
Rituximab for treatment-resistant extensive Wegener's granulomatosis--additive effects of a maintenance treatment with leflunomide.
    Clinical rheumatology, 2007, Volume: 26, Issue:10

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal

2007