leflunomide has been researched along with Graft-Versus-Host Disease in 10 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this model, we evaluated the role of leflunomide on the development of lupus nephritis in system autoimmunity." | 7.78 | Therapeutic effect of leflunomide on the development of experimental lupus nephritis in mice. ( He, C; Liu, S; Lu, X; Luo, P; Wu, M; Yan, Z; Yu, Y, 2012) |
| " In this model, we evaluated the role of leflunomide on the development of lupus nephritis in system autoimmunity." | 3.78 | Therapeutic effect of leflunomide on the development of experimental lupus nephritis in mice. ( He, C; Liu, S; Lu, X; Luo, P; Wu, M; Yan, Z; Yu, Y, 2012) |
| "Leflunomide has been shown to be very effective in preventing and curing several autoimmune animal diseases." | 2.38 | Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection. ( Bartlett, RR; Bremer, E; Dimitrijevic, M; Germann, T; Küchle, CC; Mattar, T; Rüde, E; Schorlemmer, HU; Thoenes, GH; Zielinski, T, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Punatar, S | 1 |
| Mohite, A | 1 |
| Gokarn, A | 1 |
| Nayak, L | 1 |
| Bonda, A | 1 |
| Shanmugam, K | 1 |
| Vijaysekharan, K | 1 |
| Khattry, N | 1 |
| Gagneux-Brunon, A | 1 |
| Pillet, S | 1 |
| Laurent, B | 1 |
| Mariat, C | 1 |
| Michalet, M | 1 |
| Lucht, F | 1 |
| Botelho-Nevers, E | 1 |
| He, C | 1 |
| Lu, X | 1 |
| Yan, Z | 1 |
| Wu, M | 1 |
| Liu, S | 1 |
| Yu, Y | 1 |
| Luo, P | 1 |
| Avery, RK | 1 |
| Bolwell, BJ | 1 |
| Yen-Lieberman, B | 1 |
| Lurain, N | 1 |
| Waldman, WJ | 1 |
| Longworth, DL | 1 |
| Taege, AJ | 1 |
| Mossad, SB | 1 |
| Kohn, D | 1 |
| Long, JR | 1 |
| Curtis, J | 1 |
| Kalaycio, M | 1 |
| Pohlman, B | 1 |
| Williams, JW | 2 |
| Mrowka, C | 1 |
| Thoenes, GH | 2 |
| Langer, KH | 1 |
| Bartlett, RR | 3 |
| Foster, PF | 1 |
| Xiao, F | 1 |
| Kociss, K | 1 |
| Chong, AS | 1 |
| Sankary, HN | 1 |
| McChesney, L | 1 |
| Cohn, S | 1 |
| Lui, LT | 1 |
| Lai, YC | 1 |
| Yeh, LS | 1 |
| Hou, SM | 1 |
| Jeng, CR | 1 |
| Gregory, CR | 1 |
| Dimitrijevic, M | 1 |
| Mattar, T | 1 |
| Zielinski, T | 1 |
| Germann, T | 1 |
| Rüde, E | 1 |
| Küchle, CC | 1 |
| Schorlemmer, HU | 1 |
| Bremer, E | 1 |
| Popovic, S | 1 |
1 review available for leflunomide and Graft-Versus-Host Disease
| Article | Year |
|---|---|
Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection.
Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoimmune Diseases; Disease | 1991 |
9 other studies available for leflunomide and Graft-Versus-Host Disease
| Article | Year |
|---|---|
Leflunomide for chronic musculoskeletal graft versus host disease following allogeneic hematopoietic stem cell transplant.
Topics: Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Leflunomide; Transplantation | 2020 |
A case of BK virus nephropathy in a stem cell transplant recipient: a rare or under-recognized cause for Acute Kidney injury.
Topics: Acute Kidney Injury; Anti-Bacterial Agents; BK Virus; Ciprofloxacin; Cord Blood Stem Cell Transplant | 2015 |
Therapeutic effect of leflunomide on the development of experimental lupus nephritis in mice.
Topics: Animals; Antigen-Antibody Complex; Ascites; Cell Proliferation; Disease Models, Animal; Female; Graf | 2012 |
Use of leflunomide in an allogeneic bone marrow transplant recipient with refractory cytomegalovirus infection.
Topics: Bone Marrow Transplantation; Cytomegalovirus Infections; Drug Resistance, Viral; Drug Therapy, Combi | 2004 |
Prevention of the acute graft-versus-host disease (GVHD) in rats by the immunomodulating drug leflunomide.
Topics: Acute Disease; Animals; Conjunctivitis; Dermatitis; Graft vs Host Disease; Hybridization, Genetic; I | 1994 |
Leflunomide immunosuppression in rat small intestinal transplantation.
Topics: Animals; Graft Rejection; Graft Survival; Graft vs Host Disease; Immunosuppressive Agents; Intestine | 1994 |
Irradiation or temporal variations in immunosuppressive schedules do not prevent graft-versus-host disease following rat limb allotransplantation.
Topics: Animals; Cyclosporine; Drug Administration Schedule; Extremities; Graft Rejection; Graft vs Host Dis | 1998 |
Leflunomide. Arava, HWA 486, SU 101.
Topics: Animals; Dogs; Drugs, Investigational; Graft Rejection; Graft vs Host Disease; Heart Transplantation | 1999 |
The use of the murine chronic graft vs host (CGVH) disease, a model for systemic lupus erythematosus (SLE), for drug discovery.
Topics: Animals; Cyclophosphamide; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Graft vs Ho | 1987 |