leflunomide has been researched along with Genetic Predisposition in 4 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Leflunomide has been reported as an immunomodulating agent which acts on a variety of cells including T- and B-lymphocytes." | 1.29 | Protective effect of leflunomide on the natural course of Leishmania major-induced disease in genetically susceptible BALB/c mice. ( Asmuss, PA; Humborg, C; Röllinghoff, M; Solbach, W; Zimmermann, S, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hopkins, AM | 1 |
| O'Doherty, CE | 1 |
| Foster, DJ | 1 |
| Suppiah, V | 1 |
| Upton, RN | 1 |
| Spargo, LD | 1 |
| Cleland, LG | 1 |
| Proudman, SM | 1 |
| Wiese, MD | 1 |
| Kudo, S | 1 |
| Solbach, W | 1 |
| Asmuss, PA | 1 |
| Zimmermann, S | 1 |
| Humborg, C | 1 |
| Röllinghoff, M | 1 |
| Yocum, DE | 1 |
2 reviews available for leflunomide and Genetic Predisposition
| Article | Year |
|---|---|
[Drug induced lung injuries in Japanese population].
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Asian People; Bleomycin; Gefitinib; Genetic Predisposi | 2006 |
T cells: pathogenic cells and therapeutic targets in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Arthritis, Rheumatoid; Clone Cells; Genetic P | 1999 |
2 other studies available for leflunomide and Genetic Predisposition
| Article | Year |
|---|---|
The rheumatoid arthritis susceptibility polymorphism PTPN22 C1858T is not associated with leflunomide response or toxicity.
Topics: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Genetic Predi | 2014 |
Protective effect of leflunomide on the natural course of Leishmania major-induced disease in genetically susceptible BALB/c mice.
Topics: Animals; Antiparasitic Agents; Antiprotozoal Agents; Female; Genetic Predisposition to Disease; Immu | 1995 |