leflunomide has been researched along with Fibroma, Shope in 29 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Leflunomide, an immunosuppressant with antiviral activity, was used to treat 5 children with severe BK virus-associated hemorrhagic cystitis after hematopoietic stem cell transplantation." | 7.80 | Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: a pilot study. ( Chao, YH; Peng, CT; Sheu, JN; Weng, T; Wu, HP; Wu, KH, 2014) |
| "Leflunomide is an immunosuppressive drug with antiviral activity and has been used in treating BKV-associated nephropathy after renal transplantation." | 5.39 | Efficacy and safety of leflunomide for the treatment of BK virus-associated hemorrhagic cystitis in allogeneic hematopoietic stem cell transplantation recipients. ( Chen, XC; He, C; Huang, R; Li, JJ; Liu, T; Meng, WT, 2013) |
| " Patients with significant viremia and/or biopsy-proven BKPVAN were treated with immunosuppression reduction and leflunomide." | 3.85 | Stabilization of renal function after the first year of follow-up in kidney transplant recipients treated for significant BK polyomavirus infection or BK polyomavirus-associated nephropathy. ( Bodson-Clermont, P; Cardinal, H; Fortin, MC; Girardin, C; Hébert, MJ; Lévesque, R; Pâquet, MR; Renoult, E; Simard-Meilleur, MC; St-Louis, G, 2017) |
| "This analysis demonstrates for the first time that, used in a stepwise fashion, ciprofloxacin and leflunomide are effective and safe treatments for BK viremia in PRTR." | 3.80 | A novel treatment regimen for BK viremia. ( Cheam, H; Ettenger, RB; Malekzadeh, MH; Tsai, EW; Zaman, RA, 2014) |
| "Leflunomide, an immunosuppressant with antiviral activity, was used to treat 5 children with severe BK virus-associated hemorrhagic cystitis after hematopoietic stem cell transplantation." | 3.80 | Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: a pilot study. ( Chao, YH; Peng, CT; Sheu, JN; Weng, T; Wu, HP; Wu, KH, 2014) |
| "Leflunomide has shown promising results in BKVAN." | 2.66 | Leflunomide in the treatment of BK polyomavirus associated nephropathy in kidney transplanted patients - A systematic review. ( Dräger, DL; Hakenberg, OW; Kranz, J; Neumann, T; Schneidewind, L, 2020) |
| "Leflunomide is an immunosuppressive drug with in vitro and initial observational evidence of antiviral activity against BK virus (BKV), a pathogen that causes opportunistic infection upon reactivation in renal transplant recipients." | 2.55 | Clinical Pharmacokinetic Monitoring of Leflunomide in Renal Transplant Recipients with BK Virus Reactivation: A Review of the Literature. ( Ensom, MHH; Leung, M; Ng, JCY; Wright, AJ, 2017) |
| "BK viremia and nephritis are increasing problems in renal transplant recipients." | 2.43 | BK virus nephritis after renal transplantation. ( Hariharan, S, 2006) |
| "Treatment with leflunomide was continued until BK virus was undetectable by polymerase chain reaction in at least 2 blood samples 2 weeks apart." | 1.91 | Effect of Leflunomide on Treatment of Pediatric Renal Transplant Recipients With BK Virus Infection. ( Askiti, V; Darema, M; Gole, E; Malakasioti, G; Mitsioni, A, 2023) |
| "Leflunomide has both antiviral and immunosuppressive effects, and clinical research has demonstrated its clinical efficacy against BKVN." | 1.56 | Use of Leflunomide as an Antiviral Agent with Everolimus for BK Virus Nephropathy Patients After Kidney Transplantation: A Case Series. ( Shirai, H; Tojimbara, T; Yamazaki, T, 2020) |
| "Treatment with leflunomide was started after a mean of 1." | 1.51 | Clinical utility of leflunomide for BK polyomavirus associated nephropathy in kidney transplant recipients: A multicenter retrospective study. ( Bouvier, N; Caillard, S; Conrad, A; Duquennoy, S; Fafi-Kremer, S; Hurault De Ligny, B; Keller, N; Morelon, E; Moulin, B, 2019) |
| " The dosage of mycophenolate sodium was tapered from 720 to 360 mg daily and that of everolimus increased from 0." | 1.51 | Successful Treatment for BK Virus Nephropathy by Leflunomide in a Kidney Transplant Patient: A Case Report. ( Chen, HA; Chen, YW; Hsu, YH; Hung, LY; Lee, CH; Wu, MS; Wu, MY, 2019) |
| " The dosage and time of therapy need to be explored in the future; additional studies of large samples are needed." | 1.42 | BK Virus-Associated Nephropathy with Plasma Cell-Rich Infiltrates Treated by Bortezomib-Based Regimen. ( Chen, JS; Cheng, DR; Ji, SM; Li, X; Liu, ZH; Wen, JQ; Wu, D; Xie, KN; Zhang, MC, 2015) |
| "Leflunomide is an immunosuppressive drug with antiviral activity and has been used in treating BKV-associated nephropathy after renal transplantation." | 1.39 | Efficacy and safety of leflunomide for the treatment of BK virus-associated hemorrhagic cystitis in allogeneic hematopoietic stem cell transplantation recipients. ( Chen, XC; He, C; Huang, R; Li, JJ; Liu, T; Meng, WT, 2013) |
| "Treatment with leflunomide reduced serum viral titres and stabilized renal function." | 1.38 | Native kidney BK virus nephropathy associated with chronic lymphocytic leukaemia. ( Gray, M; Leonard, N; McCrory, R; Smyth, J; Woodman, A, 2012) |
| "Leflunomide has been studied for the treatment of BK viremia and nephropathy, but there are limited data on the utility of leflunomide therapeutic drug monitoring." | 1.38 | Leflunomide efficacy and pharmacodynamics for the treatment of BK viral infection. ( Baliga, P; Bratton, C; Chavin, K; Krisl, JC; McGillicuddy, J; Pilch, N; Taber, DJ; Thomas, B, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 17 (58.62) | 24.3611 |
| 2020's | 6 (20.69) | 2.80 |
| Authors | Studies |
|---|---|
| Favi, E | 1 |
| Signorini, L | 1 |
| Villani, S | 1 |
| Dolci, M | 1 |
| Ticozzi, R | 1 |
| Basile, G | 1 |
| Ferrante, P | 1 |
| Ferraresso, M | 1 |
| Delbue, S | 1 |
| Rasaei, N | 1 |
| Malekmakan, L | 1 |
| Gholamabbas, G | 1 |
| Abdizadeh, P | 1 |
| Gole, E | 1 |
| Mitsioni, A | 1 |
| Darema, M | 1 |
| Malakasioti, G | 1 |
| Askiti, V | 1 |
| Alfano, G | 1 |
| Fontana, F | 1 |
| Guaraldi, G | 1 |
| Cappelli, G | 1 |
| Mussini, C | 1 |
| Schneidewind, L | 1 |
| Neumann, T | 1 |
| Dräger, DL | 1 |
| Kranz, J | 1 |
| Hakenberg, OW | 1 |
| Yamazaki, T | 1 |
| Shirai, H | 1 |
| Tojimbara, T | 1 |
| Keller, N | 1 |
| Duquennoy, S | 1 |
| Conrad, A | 1 |
| Fafi-Kremer, S | 1 |
| Morelon, E | 1 |
| Bouvier, N | 1 |
| Moulin, B | 1 |
| Hurault De Ligny, B | 1 |
| Caillard, S | 1 |
| Wu, MY | 1 |
| Chen, YW | 1 |
| Hung, LY | 1 |
| Lee, CH | 1 |
| Chen, HA | 1 |
| Hsu, YH | 1 |
| Wu, MS | 1 |
| Chen, XC | 1 |
| Liu, T | 1 |
| Li, JJ | 1 |
| He, C | 1 |
| Meng, WT | 1 |
| Huang, R | 1 |
| Kuppachi, S | 1 |
| Thomas, B | 2 |
| Kokko, KE | 1 |
| Mutlu, D | 1 |
| Sağlık, I | 1 |
| Koyun, M | 1 |
| Comak, E | 1 |
| Mutlu, E | 1 |
| Uslu Gökçeoğlu, A | 1 |
| Cağla Doğan, S | 1 |
| Dinçkan, A | 1 |
| Akbaş, SH | 1 |
| Akkaya, B | 1 |
| Akman, S | 1 |
| Süleymanlar, G | 1 |
| Colak, D | 1 |
| Zaman, RA | 1 |
| Ettenger, RB | 1 |
| Cheam, H | 1 |
| Malekzadeh, MH | 1 |
| Tsai, EW | 1 |
| Wu, KH | 1 |
| Weng, T | 1 |
| Wu, HP | 1 |
| Peng, CT | 1 |
| Sheu, JN | 1 |
| Chao, YH | 1 |
| Halim, MA | 1 |
| Al-Otaibi, T | 1 |
| Gheith, O | 1 |
| Zkaria, Z | 1 |
| Mosaad, A | 1 |
| Said, T | 1 |
| Nair, P | 1 |
| Nampoory, N | 1 |
| Wu, D | 1 |
| Zhang, MC | 1 |
| Chen, JS | 1 |
| Li, X | 1 |
| Cheng, DR | 1 |
| Xie, KN | 1 |
| Ji, SM | 1 |
| Liu, ZH | 1 |
| Wen, JQ | 1 |
| Gagneux-Brunon, A | 1 |
| Pillet, S | 1 |
| Laurent, B | 1 |
| Mariat, C | 1 |
| Michalet, M | 1 |
| Lucht, F | 1 |
| Botelho-Nevers, E | 1 |
| Simard-Meilleur, MC | 1 |
| Bodson-Clermont, P | 1 |
| St-Louis, G | 1 |
| Pâquet, MR | 1 |
| Girardin, C | 1 |
| Fortin, MC | 1 |
| Cardinal, H | 1 |
| Hébert, MJ | 1 |
| Lévesque, R | 1 |
| Renoult, E | 1 |
| Ng, JCY | 1 |
| Leung, M | 1 |
| Wright, AJ | 1 |
| Ensom, MHH | 1 |
| Jaw, J | 1 |
| Hill, P | 1 |
| Goodman, D | 1 |
| Mazzucco, G | 1 |
| Costa, C | 1 |
| Bergallo, M | 1 |
| Segoloni, GP | 1 |
| Monga, G | 1 |
| Wu, JK | 1 |
| Harris, MT | 1 |
| Araya, CE | 1 |
| Garin, EH | 1 |
| Neiberger, RE | 1 |
| Dharnidharka, VR | 1 |
| McCrory, R | 1 |
| Gray, M | 1 |
| Leonard, N | 1 |
| Smyth, J | 1 |
| Woodman, A | 1 |
| Krisl, JC | 1 |
| Taber, DJ | 1 |
| Pilch, N | 1 |
| Chavin, K | 1 |
| Bratton, C | 1 |
| McGillicuddy, J | 1 |
| Baliga, P | 1 |
| Jung, YH | 1 |
| Moon, KC | 1 |
| Ha, JW | 1 |
| Kim, SJ | 1 |
| Ha, IS | 1 |
| Cheong, HI | 1 |
| Kang, HG | 1 |
| Williams, JW | 1 |
| Javaid, B | 1 |
| Kadambi, PV | 1 |
| Gillen, D | 1 |
| Harland, R | 1 |
| Thistlewaite, JR | 1 |
| Garfinkel, M | 1 |
| Foster, P | 1 |
| Atwood, W | 1 |
| Millis, JM | 1 |
| Meehan, SM | 1 |
| Josephson, MA | 1 |
| Hariharan, S | 1 |
| Duclos, AJ | 1 |
| Krishnamurthi, V | 1 |
| Lard, M | 1 |
| Poggio, E | 1 |
| Kleeman, M | 1 |
| Winans, C | 1 |
| Fatica, R | 1 |
| Nurko, S | 1 |
| Faguer, S | 1 |
| Hirsch, HH | 1 |
| Kamar, N | 1 |
| Guilbeau-Frugier, C | 1 |
| Ribes, D | 1 |
| Guitard, J | 1 |
| Esposito, L | 1 |
| Cointault, O | 1 |
| Modesto, A | 1 |
| Lavit, M | 1 |
| Mengelle, C | 1 |
| Rostaing, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| BK Viremia and BK Virus Nephropathy Post Kidney Transplant Comparison of New Practices With Traditional Approach: A Combined Retrospective Chart Review and Prospective Observational Study[NCT02758288] | 0 participants (Actual) | Observational | 2015-09-30 | Withdrawn | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for leflunomide and Fibroma, Shope
| Article | Year |
|---|---|
Leflunomide in the treatment of BK polyomavirus associated nephropathy in kidney transplanted patients - A systematic review.
Topics: BK Virus; Humans; Kidney; Kidney Diseases; Leflunomide; Polyomavirus Infections; Tumor Virus Infecti | 2020 |
BK virus in the kidney transplant patient.
Topics: BK Virus; Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Transplantat | 2013 |
Clinical Pharmacokinetic Monitoring of Leflunomide in Renal Transplant Recipients with BK Virus Reactivation: A Review of the Literature.
Topics: Animals; BK Virus; Clinical Decision-Making; Humans; Isoxazoles; Kidney Transplantation; Leflunomide | 2017 |
Use of leflunomide in the treatment of polyomavirus BK-associated nephropathy.
Topics: BK Virus; Humans; Isoxazoles; Kidney Diseases; Kidney Transplantation; Leflunomide; Polyomavirus Inf | 2008 |
Leflunomide therapy for BK virus allograft nephropathy after pediatric kidney transplantation.
Topics: Antiviral Agents; BK Virus; Child; Female; Humans; Isoxazoles; Kidney Diseases; Kidney Transplantati | 2013 |
BK virus nephritis after renal transplantation.
Topics: Antibodies, Viral; Antiviral Agents; BK Virus; Cidofovir; Cytosine; DNA, Viral; Graft Survival; Huma | 2006 |
1 trial available for leflunomide and Fibroma, Shope
| Article | Year |
|---|---|
Comparative Study of Intravenous Immunoglobulin and Leflunomide Combination Therapy With Intravenous Immunoglobulin Single Therapy in Kidney Transplant Patients With BK Virus Infection: Single-Center Clinical Trial.
Topics: Antiviral Agents; BK Virus; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Kidney T | 2023 |
22 other studies available for leflunomide and Fibroma, Shope
| Article | Year |
|---|---|
In Vitro Study Evaluating the Effect of Different Immunosuppressive Agents on Human Polyomavirus BK Replication.
Topics: Antiviral Agents; BK Virus; Everolimus; Humans; Immunosuppressive Agents; Kidney Transplantation; Le | 2022 |
Effect of Leflunomide on Treatment of Pediatric Renal Transplant Recipients With BK Virus Infection.
Topics: BK Virus; Child; Humans; Immunosuppressive Agents; Kidney; Kidney Transplantation; Leflunomide; Poly | 2023 |
Successful treatment of BK virus associated-nephropathy in a human immunodeficiency virus-positive kidney transplant recipient.
Topics: AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; BK Virus; CD4 Lymphocy | 2020 |
Use of Leflunomide as an Antiviral Agent with Everolimus for BK Virus Nephropathy Patients After Kidney Transplantation: A Case Series.
Topics: Antiviral Agents; BK Virus; Everolimus; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Tr | 2020 |
Clinical utility of leflunomide for BK polyomavirus associated nephropathy in kidney transplant recipients: A multicenter retrospective study.
Topics: Adult; Aged; Female; Graft Rejection; Humans; Immunosuppressive Agents; Kidney; Kidney Diseases; Kid | 2019 |
Successful Treatment for BK Virus Nephropathy by Leflunomide in a Kidney Transplant Patient: A Case Report.
Topics: BK Virus; Everolimus; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Kidney Trans | 2019 |
Efficacy and safety of leflunomide for the treatment of BK virus-associated hemorrhagic cystitis in allogeneic hematopoietic stem cell transplantation recipients.
Topics: Adult; BK Virus; Cystitis; Enzyme Inhibitors; Female; Hematopoietic Stem Cell Transplantation; Hemor | 2013 |
[BK virus infections in pediatric kidney transplant recipients].
Topics: Adolescent; Antiviral Agents; BK Virus; Child; Cidofovir; Cytosine; DNA, Viral; Female; Graft Reject | 2013 |
A novel treatment regimen for BK viremia.
Topics: Adolescent; BK Virus; Child; Ciprofloxacin; Female; Fluoroquinolones; Glomerular Filtration Rate; Hu | 2014 |
Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: a pilot study.
Topics: Adolescent; BK Virus; Child; Cystitis; Female; Hematopoietic Stem Cell Transplantation; Hematuria; H | 2014 |
Active management versus minimization of immunosuppressives of BK virus-associated nephropathy after a kidney transplant.
Topics: Adult; Antiviral Agents; Biopsy; BK Virus; Ciprofloxacin; Drug Substitution; Drug Therapy, Combinati | 2014 |
BK Virus-Associated Nephropathy with Plasma Cell-Rich Infiltrates Treated by Bortezomib-Based Regimen.
Topics: Adult; Antineoplastic Agents; BK Virus; Bortezomib; Female; Humans; Isoxazoles; Kidney Diseases; Kid | 2015 |
A case of BK virus nephropathy in a stem cell transplant recipient: a rare or under-recognized cause for Acute Kidney injury.
Topics: Acute Kidney Injury; Anti-Bacterial Agents; BK Virus; Ciprofloxacin; Cord Blood Stem Cell Transplant | 2015 |
Stabilization of renal function after the first year of follow-up in kidney transplant recipients treated for significant BK polyomavirus infection or BK polyomavirus-associated nephropathy.
Topics: Adult; Allografts; Antiviral Agents; Biopsy; BK Virus; DNA, Viral; Female; Follow-Up Studies; Glomer | 2017 |
Combination of Leflunomide and Everolimus for treatment of BK virus nephropathy.
Topics: Aged; BK Virus; Drug Substitution; Drug Therapy, Combination; Everolimus; Female; Graft Rejection; G | 2017 |
Severe crescentic BK virus nephropathy with favourable outcome in a transplanted patient treated with Leflunomide.
Topics: Adult; Antiviral Agents; BK Virus; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Glomerulus; | 2008 |
Leflunomide therapy for BK virus allograft nephropathy in pediatric and young adult kidney transplant recipients.
Topics: Antiviral Agents; BK Virus; Child; DNA, Viral; Dose-Response Relationship, Drug; Enzyme Inhibitors; | 2010 |
Native kidney BK virus nephropathy associated with chronic lymphocytic leukaemia.
Topics: Aged; BK Virus; DNA, Viral; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Diseases; Leflunomi | 2012 |
Leflunomide efficacy and pharmacodynamics for the treatment of BK viral infection.
Topics: Adult; Aniline Compounds; Antiviral Agents; Biotransformation; BK Virus; Chi-Square Distribution; Cr | 2012 |
Leflunomide for polyomavirus type BK nephropathy.
Topics: Aniline Compounds; Antiviral Agents; BK Virus; Crotonates; Humans; Hydroxybutyrates; Isoxazoles; Kid | 2005 |
Prevalence and clinical course of BK virus nephropathy in pancreas after kidney transplant patients.
Topics: Antiviral Agents; BK Virus; Drug Therapy, Combination; Humans; Immunosuppression Therapy; Isoxazoles | 2006 |
Leflunomide treatment for polyomavirus BK-associated nephropathy after kidney transplantation.
Topics: Adult; Antiviral Agents; BK Virus; Female; Humans; Immunosuppression Therapy; Isoxazoles; Kidney Dis | 2007 |