leflunomide has been researched along with Endometriosis in 4 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Endometriosis: A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of the leflunomide (LEF) on the size of the transplanted endometriosis (EMS) lesions and trans- forming growth factor (TGF) -β1gray level in SD rats." | 7.85 | The effect of leflunomide on the transplanted endometriosis lesions in SD rats. ( Ding, SG; Feng, XM; Gao, Y; Guo, HF; Tao, BB; Wang, CH; Wang, LK; Wang, YH; Wu, AH; Yang, JJ; Zhai, GR, 2017) |
| "The effect of immunomodulator leflunomide on the development of an experimental endometriosis model was assessed by surgically transplanting autologous fragments of endometrial tissue onto the inner surface of the abdominal wall and arterial cascades of the small intestines." | 7.74 | Effect of the immunomodulator leflunomide on the induction of endometriosis in an experimental rat model. ( Aytan, H; Batioglu, S; Caglar, P; Uygur, D; Zergeroglu, S, 2007) |
| "Leflunomide appeared to cause regression of experimental endometriosis in rats." | 7.73 | Leflunomide--an immunomodulator--induces regression of endometrial explants in a rat model of endometriosis. ( Aytan, H; Batioglu, S; Uygur, D; Zergeroglu, S, 2006) |
| "To investigate the effects of the leflunomide (LEF) on the size of the transplanted endometriosis (EMS) lesions and trans- forming growth factor (TGF) -β1gray level in SD rats." | 3.85 | The effect of leflunomide on the transplanted endometriosis lesions in SD rats. ( Ding, SG; Feng, XM; Gao, Y; Guo, HF; Tao, BB; Wang, CH; Wang, LK; Wang, YH; Wu, AH; Yang, JJ; Zhai, GR, 2017) |
| "The effect of immunomodulator leflunomide on the development of an experimental endometriosis model was assessed by surgically transplanting autologous fragments of endometrial tissue onto the inner surface of the abdominal wall and arterial cascades of the small intestines." | 3.74 | Effect of the immunomodulator leflunomide on the induction of endometriosis in an experimental rat model. ( Aytan, H; Batioglu, S; Caglar, P; Uygur, D; Zergeroglu, S, 2007) |
| "Leflunomide appeared to cause regression of experimental endometriosis in rats." | 3.73 | Leflunomide--an immunomodulator--induces regression of endometrial explants in a rat model of endometriosis. ( Aytan, H; Batioglu, S; Uygur, D; Zergeroglu, S, 2006) |
| "Endometriosis is an enigmatic, debilitating disease which affects as many as 15% of all women of reproductive age and is characterized by pelvic pain and infertility." | 2.46 | Endometriosis: in search of optimal treatment. ( Nothnick, WB, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, JJ | 1 |
| Gao, Y | 1 |
| Wang, YH | 1 |
| Wang, CH | 1 |
| Wang, LK | 1 |
| Tao, BB | 1 |
| Guo, HF | 1 |
| Ding, SG | 1 |
| Wu, AH | 1 |
| Zhai, GR | 1 |
| Feng, XM | 1 |
| Nothnick, WB | 1 |
| Uygur, D | 2 |
| Aytan, H | 2 |
| Zergeroglu, S | 2 |
| Batioglu, S | 2 |
| Caglar, P | 1 |
1 review available for leflunomide and Endometriosis
| Article | Year |
|---|---|
Endometriosis: in search of optimal treatment.
Topics: Adalimumab; Anastrozole; Angiogenesis Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Antibodie | 2010 |
3 other studies available for leflunomide and Endometriosis
| Article | Year |
|---|---|
The effect of leflunomide on the transplanted endometriosis lesions in SD rats.
Topics: Animals; Endometriosis; Female; Immunosuppressive Agents; Isoxazoles; Leflunomide; Rats, Sprague-Daw | 2017 |
Leflunomide--an immunomodulator--induces regression of endometrial explants in a rat model of endometriosis.
Topics: Animals; Disease Models, Animal; Endometriosis; Endometrium; Female; Immunologic Factors; Isoxazoles | 2006 |
Effect of the immunomodulator leflunomide on the induction of endometriosis in an experimental rat model.
Topics: Animals; Disease Models, Animal; Endometriosis; Female; Immunologic Factors; Isoxazoles; Leflunomide | 2007 |