leflunomide has been researched along with ER-Negative PR-Negative HER2-Negative Breast Cancer in 2 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with leflunomide, a potent activator of mitochondrial fusion proteins, overcame inhibitory effects of fission on migration, signaling, and metastasis." | 1.56 | Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer. ( Bevoor, A; Boppisetti, J; Buschhaus, JM; Chen, YC; Chiang, B; Cutter, AC; Eckley, S; Ghosh, P; Haley, HR; Humphries, BA; Lahann, J; Luker, GD; Luker, KE; Neale, DB; Palagama, DSW; Qyli, T; Robison, TH; Ross, BD; Sahoo, D; Sahoo, S; Spinosa, PC; Yoon, E, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Humphries, BA | 1 |
| Cutter, AC | 1 |
| Buschhaus, JM | 1 |
| Chen, YC | 1 |
| Qyli, T | 1 |
| Palagama, DSW | 1 |
| Eckley, S | 1 |
| Robison, TH | 1 |
| Bevoor, A | 1 |
| Chiang, B | 1 |
| Haley, HR | 1 |
| Sahoo, S | 1 |
| Spinosa, PC | 1 |
| Neale, DB | 1 |
| Boppisetti, J | 1 |
| Sahoo, D | 1 |
| Ghosh, P | 1 |
| Lahann, J | 1 |
| Ross, BD | 1 |
| Yoon, E | 1 |
| Luker, KE | 1 |
| Luker, GD | 1 |
| Brown, KK | 1 |
| Spinelli, JB | 1 |
| Asara, JM | 1 |
| Toker, A | 1 |
2 other studies available for leflunomide and ER-Negative PR-Negative HER2-Negative Breast Cancer
| Article | Year |
|---|---|
Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer.
Topics: Animals; Bone Neoplasms; Carboxy-Lyases; Cell Transformation, Neoplastic; Female; Humans; Immunosupp | 2020 |
Adaptive Reprogramming of
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line | 2017 |