leflunomide has been researched along with Dyspnea in 7 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Dyspnea: Difficult or labored breathing.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset short-of-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide." | 7.74 | Diffuse alveolar hemorrhage after leflunomide therapy in a patient with rheumatoid arthritis. ( Carloni, A; Giannakakis, K; Nori, G; Piciucchi, S; Poletti, V; Zobel, BB, 2008) |
| "Recurrences of COVID-19 were observed in a patient with long-term usage of hydroxychloroquine, leflunomide, and glucocorticoids due to her 30-year history of rheumatoid arthritis (RA)." | 5.05 | A complex COVID-19 case with rheumatoid arthritis treated with tocilizumab. ( Cai, S; Dong, L; Li, M; Sun, W, 2020) |
| "We report the case of a 60 year female patient suffering from rheumatoid arthritis for the last 25 years, under TNF-blocker and leflunomide, affected by a recurrent pneumothorax with several subpleural nodules, basal bronchiectasis and apical bullous emphysema." | 4.85 | [Referring to an unusual case: pulmonary affection and rheumatoid arthritis]. ( Borges, H; Frey, JG; Schnyder, JM; Tschopp, JM, 2009) |
| " A diagnosis of stage 2 sarcoidosis with pleural involvement was made and treatment with prednisone was started." | 3.75 | A 50-year-old man with stage 2 sarcoidosis with pleural involvement. ( Arrossi, A; Modrykamien, A; Reddy, A, 2009) |
| "We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset short-of-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide." | 3.74 | Diffuse alveolar hemorrhage after leflunomide therapy in a patient with rheumatoid arthritis. ( Carloni, A; Giannakakis, K; Nori, G; Piciucchi, S; Poletti, V; Zobel, BB, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, S | 1 |
| Sun, W | 1 |
| Li, M | 1 |
| Dong, L | 1 |
| Hamilton, JA | 1 |
| Bishop, JM | 1 |
| Modrykamien, A | 1 |
| Arrossi, A | 1 |
| Reddy, A | 1 |
| Borges, H | 1 |
| Schnyder, JM | 1 |
| Frey, JG | 1 |
| Tschopp, JM | 1 |
| Mohr, M | 1 |
| Jacobi, AM | 1 |
| Baughman, RP | 1 |
| Nunes, H | 1 |
| Sweiss, NJ | 1 |
| Lower, EE | 1 |
| Carloni, A | 1 |
| Piciucchi, S | 1 |
| Giannakakis, K | 1 |
| Nori, G | 1 |
| Zobel, BB | 1 |
| Poletti, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Endobronchial Mucosal Biopsy in Patients With Suspected Pulmonary Sarcoidosis[NCT04904939] | 20 participants (Actual) | Interventional | 2020-05-15 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for leflunomide and Dyspnea
| Article | Year |
|---|---|
A complex COVID-19 case with rheumatoid arthritis treated with tocilizumab.
Topics: Aged; Anti-Bacterial Agents; Antifungal Agents; Antirheumatic Agents; Antiviral Agents; Arthritis, R | 2020 |
[Referring to an unusual case: pulmonary affection and rheumatoid arthritis].
Topics: Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchiectasis; Dyspnea; Female; | 2009 |
Established and experimental medical therapy of pulmonary sarcoidosis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Azathioprine; Clinical Trials | 2013 |
4 other studies available for leflunomide and Dyspnea
| Article | Year |
|---|---|
69-year-old woman with rheumatoid arthritis presents with shortness of breath and cough.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Bronchoalveolar Lavage; Bronch | 2014 |
A 50-year-old man with stage 2 sarcoidosis with pleural involvement.
Topics: Antirheumatic Agents; Dyspnea; Humans; Isoxazoles; Leflunomide; Lung; Male; Middle Aged; Pleural Dis | 2009 |
Interstitial lung disease in rheumatoid arthritis: response to IL-6R blockade.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchoalveolar Lava | 2011 |
Diffuse alveolar hemorrhage after leflunomide therapy in a patient with rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biopsy; Diagnosis, Differenti | 2008 |