leflunomide has been researched along with Duncan Disease in 3 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Brequinar sodium (BQR) was originally developed as an antitumor drug and subsequently as an immunosuppressant for controlling transplant rejection." | 5.30 | Control of lymphoproliferative and autoimmune disease in MRL-lpr/lpr mice by brequinar sodium: mechanisms of action. ( Blinder, L; Chong, AS; Gong, H; Shen, J; Williams, JW; Xu, X, 1997) |
| "Brequinar sodium (BQR) was originally developed as an antitumor drug and subsequently as an immunosuppressant for controlling transplant rejection." | 1.30 | Control of lymphoproliferative and autoimmune disease in MRL-lpr/lpr mice by brequinar sodium: mechanisms of action. ( Blinder, L; Chong, AS; Gong, H; Shen, J; Williams, JW; Xu, X, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bilger, A | 1 |
| Plowshay, J | 1 |
| Ma, S | 1 |
| Nawandar, D | 1 |
| Barlow, EA | 1 |
| Romero-Masters, JC | 1 |
| Bristol, JA | 1 |
| Li, Z | 1 |
| Tsai, MH | 1 |
| Delecluse, HJ | 1 |
| Kenney, SC | 1 |
| Xu, X | 2 |
| Blinder, L | 2 |
| Shen, J | 2 |
| Gong, H | 2 |
| Finnegan, A | 1 |
| Williams, JW | 2 |
| Chong, AS | 2 |
3 other studies available for leflunomide and Duncan Disease
| Article | Year |
|---|---|
Leflunomide/teriflunomide inhibit Epstein-Barr virus (EBV)- induced lymphoproliferative disease and lytic viral replication.
Topics: Animals; Apoptosis; B-Lymphocytes; Cell Line, Transformed; Cell Proliferation; Crotonates; Cyclin E; | 2017 |
In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice.
Topics: Aniline Compounds; Animals; Autoimmune Diseases; Crotonates; Dihydroorotate Dehydrogenase; Hydroxybu | 1997 |
Control of lymphoproliferative and autoimmune disease in MRL-lpr/lpr mice by brequinar sodium: mechanisms of action.
Topics: Animals; Autoantibodies; Autoimmune Diseases; Biphenyl Compounds; Cytidine Triphosphate; Female; Imm | 1997 |