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leflunomide and Dermatitis Medicamentosa

leflunomide has been researched along with Dermatitis Medicamentosa in 26 studies

Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Research Excerpts

ExcerptRelevanceReference
"To study the safety and efficacy of infliximab plus leflunomide combination therapy in adult rheumatoid arthritis (RA)."9.10Infliximab and leflunomide combination therapy in rheumatoid arthritis: an open-label study. ( Johnson, DM; Kiely, PD, 2002)
"A 78-year-old woman diagnosed with rheumatoid arthritis without a history of skin tumors or immunosuppressive medication, started treatment with leflunomide."7.79Multiple eruptive keratoacanthomas associated with leflunomide. ( Bouret, AM; Frances, L; Guijarro, J; Leiva-Salinas, Mdel C; Marin, I, 2013)
"A 49-year-old Japanese man with rheumatoid arthritis acutely developed a skin eruption and severe non-productive cough seventeen days after the administration of leflunomide."7.72Rheumatoid arthritis complicated with acute interstitial pneumonia induced by leflunomide as an adverse reaction. ( Haneda, K; Iwamoto, M; Kamata, Y; Kamimura, T; Masuyama, J; Minota, S; Nara, H; Okazaki, H, 2004)
"Leflunomide is an antirheumatic agent of the type of a 'disease-modifying antirheumatic drug'."5.32Erythema multiforme-like drug eruption with oral involvement after intake of leflunomide. ( Barta, U; Bauer, HI; Elsner, P; Fischer, TW; Graefe, T, 2003)
"To study the safety and efficacy of infliximab plus leflunomide combination therapy in adult rheumatoid arthritis (RA)."5.10Infliximab and leflunomide combination therapy in rheumatoid arthritis: an open-label study. ( Johnson, DM; Kiely, PD, 2002)
"A 78-year-old woman diagnosed with rheumatoid arthritis without a history of skin tumors or immunosuppressive medication, started treatment with leflunomide."3.79Multiple eruptive keratoacanthomas associated with leflunomide. ( Bouret, AM; Frances, L; Guijarro, J; Leiva-Salinas, Mdel C; Marin, I, 2013)
"Leflunomide (Arava) is an immunomodulator, recently introduced for systemic treatment of rheumatoid arthritis."3.72[Lichenoid drug reaction to leflunomide]. ( Canonne-Courivaud, D; Carpentier, O; Dejobert, Y; Delaporte, E; Hachulla, E, 2003)
"A 49-year-old Japanese man with rheumatoid arthritis acutely developed a skin eruption and severe non-productive cough seventeen days after the administration of leflunomide."3.72Rheumatoid arthritis complicated with acute interstitial pneumonia induced by leflunomide as an adverse reaction. ( Haneda, K; Iwamoto, M; Kamata, Y; Kamimura, T; Masuyama, J; Minota, S; Nara, H; Okazaki, H, 2004)
"The perforating dermatoses are a group of disorders characterized by transepidermal elimination of a material from the upper dermis."2.58Perforating disorder secondary to leflunomide and review of the literature of medications associated with perforating disorder. ( Keeley, JM; Pavlidakey, P; Sami, N, 2018)
"Prominent nail changes in lichenoid drug eruptions, particularly in children, are rare but should be considered in children with new-onset nail dystrophy."1.46Lichenoid Drug Eruption with Prominent Nail Changes Due to Leflunomide in a 12-Year-Old Child. ( Brandling-Bennett, HA; Cole, B; Fleckman, P; May, C; Sidbury, R, 2017)
"Four months later widespread prunosus skin rash appeared on her skin."1.35Severe cutaneous adverse drug reaction to leflunomide: a report of two cases. ( Guo, G; Jian, X; Li, X; Lin, D; Ruan, Y, 2008)
"Leflunomide is a new oral disease modifying antirheumatic drug with a good safety profile."1.33Lupus erythematosus with leflunomide: induction or reactivation? ( Gensburger, D; Kanitakis, J; Kawashima, M; Marotte, H; Miossec, P, 2005)
"Leflunomide is an antirheumatic agent of the type of a 'disease-modifying antirheumatic drug'."1.32Erythema multiforme-like drug eruption with oral involvement after intake of leflunomide. ( Barta, U; Bauer, HI; Elsner, P; Fischer, TW; Graefe, T, 2003)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's15 (57.69)29.6817
2010's10 (38.46)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Hu, YQ1
Mu, ZL1
Zhang, JZ1
May, C1
Fleckman, P1
Brandling-Bennett, HA1
Cole, B1
Sidbury, R1
Keeley, JM1
Pavlidakey, P1
Sami, N1
Frances, L1
Guijarro, J1
Marin, I1
Leiva-Salinas, Mdel C1
Bouret, AM1
Blasco-Morente, G1
Notario-Ferreira, I1
Rueda-Villafranca, B1
Tercedor-Sánchez, J1
Tidwell, WJ1
Malone, J1
Callen, JP1
Schmutz, JL2
Cornillier, H1
Kervarrec, T1
Tabareau-Delalande, F1
Mammou, S1
Jonville Bera, AP1
Machet, L1
Do-Pham, G1
Charachon, A1
Duong, TA1
Thille, AW1
Benhaiem, N1
Bagot, M1
Chosidow, O1
Roujeau, JC1
Wolkenstein, P1
Valeyrie-Allanore, L1
Savoia, F1
Gaddoni, G1
Casadio, C1
Spadola, G1
Patrizi, A1
Giacomini, F1
Aldi, M1
Vaish, AK1
Tripathi, AK1
Gupta, LK1
Jain, N1
Agarwal, A1
Verma, SK1
Soliotis, F1
Glover, M1
Jawad, AS1
Chan, AT1
Bradlow, A1
McNally, J1
Mohty, R1
Chaby, G1
Pannier, M1
Defossez, C1
Denoeux, JP1
Lok, C1
Canonne-Courivaud, D1
Carpentier, O1
Dejobert, Y1
Hachulla, E1
Delaporte, E1
Fischer, TW1
Bauer, HI1
Graefe, T1
Barta, U1
Elsner, P1
Kerr, OA1
Murray, CS1
Tidman, MJ1
Rivarola de Gutierrez, E1
Abaca, H1
Gensburger, D1
Kawashima, M1
Marotte, H1
Kanitakis, J1
Miossec, P1
Kamata, Y1
Nara, H1
Kamimura, T1
Haneda, K1
Iwamoto, M1
Masuyama, J1
Okazaki, H1
Minota, S1
Barbaud, A1
Trechot, P1
Suzuki, Y1
Saito, E1
Wakabayashi, T1
Suwa, A1
Suess, A1
Sticherling, M1
Jian, X1
Guo, G1
Ruan, Y1
Lin, D1
Li, X1
Kiely, PD1
Johnson, DM1

Reviews

3 reviews available for leflunomide and Dermatitis Medicamentosa

ArticleYear
Perforating disorder secondary to leflunomide and review of the literature of medications associated with perforating disorder.
    Dermatology online journal, 2018, May-15, Volume: 24, Issue:5

    Topics: Adult; Drug Eruptions; Elastin; Epidermis; Female; Humans; Immunosuppressive Agents; Leflunomide; Sk

2018
Severe skin reaction after leflunomide and etanercept in a patient with rheumatoid arthritis.
    Annals of the rheumatic diseases, 2002, Volume: 61, Issue:9

    Topics: Adult; Arthritis, Rheumatoid; Drug Eruptions; Erythema; Etanercept; Female; Humans; Immunoglobulin G

2002
[Adverse effects of conventional DMARDs and biologic DMARDs].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, Oct-28, Volume: 65 Suppl 8

    Topics: Antibodies, Monoclonal; Antirheumatic Agents; Chemical and Drug Induced Liver Injury; Cysteine; Drug

2007

Trials

1 trial available for leflunomide and Dermatitis Medicamentosa

ArticleYear
Infliximab and leflunomide combination therapy in rheumatoid arthritis: an open-label study.
    Rheumatology (Oxford, England), 2002, Volume: 41, Issue:6

    Topics: Adult; Aged; Anaphylaxis; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoa

2002

Other Studies

22 other studies available for leflunomide and Dermatitis Medicamentosa

ArticleYear
Erythema multiforme-like drug eruption in a patient with systemic lupus erythematosus treated with leflunomide.
    Dermatologic therapy, 2020, Volume: 33, Issue:3

    Topics: Drug Eruptions; Erythema Multiforme; Humans; Leflunomide; Lupus Erythematosus, Systemic

2020
Lichenoid Drug Eruption with Prominent Nail Changes Due to Leflunomide in a 12-Year-Old Child.
    Pediatric dermatology, 2017, Volume: 34, Issue:4

    Topics: Antirheumatic Agents; Child; Drug Eruptions; Female; Humans; Isoxazoles; Leflunomide; Lichenoid Erup

2017
Multiple eruptive keratoacanthomas associated with leflunomide.
    Dermatology online journal, 2013, Jul-14, Volume: 19, Issue:7

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carcinoma, Squamous Cell; Drug

2013
[Subacute cutaneous lupus erythematosus induced by golimumab].
    Medicina clinica, 2015, Sep-07, Volume: 145, Issue:5

    Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Eruptions; Drug Therapy, C

2015
Eruptive Keratoacanthomas Associated With Leflunomide.
    JAMA dermatology, 2016, Volume: 152, Issue:1

    Topics: Antirheumatic Agents; Drug Eruptions; Female; Humans; Isoxazoles; Keratoacanthoma; Leflunomide; Midd

2016
[Eruptive keratoacanthomas and leflunomide].
    Annales de dermatologie et de venereologie, 2016, Volume: 143, Issue:4

    Topics: Antirheumatic Agents; Drug Eruptions; Humans; Immunocompromised Host; Isoxazoles; Keratoacanthoma; L

2016
Interstitial granulomatous dermatitis occurring in a patient with SAPHO syndrome one month after starting leflunomide, and subsequently disappearing with ustekinumab.
    European journal of dermatology : EJD, 2016, Dec-01, Volume: 26, Issue:6

    Topics: Acquired Hyperostosis Syndrome; Adult; Dermatitis; Dermatologic Agents; Drug Eruptions; Female; Gran

2016
Drug reaction with eosinophilia and systemic symptoms and severe involvement of digestive tract: description of two cases.
    The British journal of dermatology, 2011, Volume: 165, Issue:1

    Topics: Adrenal Cortex Hormones; Adult; Aged; Anticonvulsants; Antirheumatic Agents; Colitis, Ulcerative; Dr

2011
A case of eczematous and vesicular dermatitis during anti-TNFalpha therapy for rheumatoid arthritis.
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2011, Volume: 146, Issue:4

    Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnostic Errors; Drug Eruptions; Drug Synergis

2011
An unusual case of DRESS syndrome due to leflunomide.
    BMJ case reports, 2011, Sep-04, Volume: 2011

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Candidiasis, Oral; Diagnosis, Differential; Drug Eru

2011
Leflunomide induced vasculitis--a dose-response relationship.
    Rheumatology (Oxford, England), 2003, Volume: 42, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Eruptions; Humans; Isoxazoles; Leflunomide; Male; Midd

2003
[Drug hypersensitivity syndrome induced by leflunomide].
    Annales de dermatologie et de venereologie, 2003, Volume: 130, Issue:5

    Topics: Arthritis, Rheumatoid; Drug Eruptions; Female; Humans; Immunosuppressive Agents; Isoxazoles; Lefluno

2003
[Lichenoid drug reaction to leflunomide].
    Annales de dermatologie et de venereologie, 2003, Volume: 130, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biopsy; Drug Eruptions; Female; Huma

2003
Erythema multiforme-like drug eruption with oral involvement after intake of leflunomide.
    Dermatology (Basel, Switzerland), 2003, Volume: 207, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Eruptions; Erythema Multiforme;

2003
Subacute cutaneous lupus erythematosus associated with leflunomide.
    Clinical and experimental dermatology, 2004, Volume: 29, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Eruptions; Humans; Isoxazoles;

2004
Photodistributed lichenoid drug eruption with rhabdomyolysis occurring during leflunomide therapy.
    Dermatology (Basel, Switzerland), 2004, Volume: 208, Issue:3

    Topics: Abdominal Pain; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Eruptions; Fema

2004
Lupus erythematosus with leflunomide: induction or reactivation?
    Annals of the rheumatic diseases, 2005, Volume: 64, Issue:1

    Topics: Antirheumatic Agents; Drug Eruptions; Female; Humans; Isoxazoles; Leflunomide; Lupus Erythematosus,

2005
Rheumatoid arthritis complicated with acute interstitial pneumonia induced by leflunomide as an adverse reaction.
    Internal medicine (Tokyo, Japan), 2004, Volume: 43, Issue:12

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Eruptions; Human

2004
[Drug-induced lichenoid eruptions].
    Annales de dermatologie et de venereologie, 2006, Volume: 133, Issue:4

    Topics: Drug Eruptions; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Lichenoid Erupti

2006
Leflunomide in subacute cutaneous lupus erythematosus - two sides of a coin.
    International journal of dermatology, 2008, Volume: 47, Issue:1

    Topics: Adult; Aged; Antirheumatic Agents; Diagnosis, Differential; Drug Eruptions; Enzyme Inhibitors; Eryth

2008
Severe cutaneous adverse drug reaction to leflunomide: a report of two cases.
    Cutaneous and ocular toxicology, 2008, Volume: 27, Issue:1

    Topics: Adolescent; Anti-Inflammatory Agents; Blister; Drug Eruptions; Exanthema; Female; Glucocorticoids; H

2008
Cutaneous drug reaction case reports: from the world literature.
    American journal of clinical dermatology, 2002, Volume: 3, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Capecitabine; Carbamates; Ceftriaxone; Clonidine; Deoxyc

2002