leflunomide has been researched along with Dermatitis Medicamentosa in 26 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the safety and efficacy of infliximab plus leflunomide combination therapy in adult rheumatoid arthritis (RA)." | 9.10 | Infliximab and leflunomide combination therapy in rheumatoid arthritis: an open-label study. ( Johnson, DM; Kiely, PD, 2002) |
| "A 78-year-old woman diagnosed with rheumatoid arthritis without a history of skin tumors or immunosuppressive medication, started treatment with leflunomide." | 7.79 | Multiple eruptive keratoacanthomas associated with leflunomide. ( Bouret, AM; Frances, L; Guijarro, J; Leiva-Salinas, Mdel C; Marin, I, 2013) |
| "A 49-year-old Japanese man with rheumatoid arthritis acutely developed a skin eruption and severe non-productive cough seventeen days after the administration of leflunomide." | 7.72 | Rheumatoid arthritis complicated with acute interstitial pneumonia induced by leflunomide as an adverse reaction. ( Haneda, K; Iwamoto, M; Kamata, Y; Kamimura, T; Masuyama, J; Minota, S; Nara, H; Okazaki, H, 2004) |
| "Leflunomide is an antirheumatic agent of the type of a 'disease-modifying antirheumatic drug'." | 5.32 | Erythema multiforme-like drug eruption with oral involvement after intake of leflunomide. ( Barta, U; Bauer, HI; Elsner, P; Fischer, TW; Graefe, T, 2003) |
| "To study the safety and efficacy of infliximab plus leflunomide combination therapy in adult rheumatoid arthritis (RA)." | 5.10 | Infliximab and leflunomide combination therapy in rheumatoid arthritis: an open-label study. ( Johnson, DM; Kiely, PD, 2002) |
| "A 78-year-old woman diagnosed with rheumatoid arthritis without a history of skin tumors or immunosuppressive medication, started treatment with leflunomide." | 3.79 | Multiple eruptive keratoacanthomas associated with leflunomide. ( Bouret, AM; Frances, L; Guijarro, J; Leiva-Salinas, Mdel C; Marin, I, 2013) |
| "Leflunomide (Arava) is an immunomodulator, recently introduced for systemic treatment of rheumatoid arthritis." | 3.72 | [Lichenoid drug reaction to leflunomide]. ( Canonne-Courivaud, D; Carpentier, O; Dejobert, Y; Delaporte, E; Hachulla, E, 2003) |
| "A 49-year-old Japanese man with rheumatoid arthritis acutely developed a skin eruption and severe non-productive cough seventeen days after the administration of leflunomide." | 3.72 | Rheumatoid arthritis complicated with acute interstitial pneumonia induced by leflunomide as an adverse reaction. ( Haneda, K; Iwamoto, M; Kamata, Y; Kamimura, T; Masuyama, J; Minota, S; Nara, H; Okazaki, H, 2004) |
| "The perforating dermatoses are a group of disorders characterized by transepidermal elimination of a material from the upper dermis." | 2.58 | Perforating disorder secondary to leflunomide and review of the literature of medications associated with perforating disorder. ( Keeley, JM; Pavlidakey, P; Sami, N, 2018) |
| "Prominent nail changes in lichenoid drug eruptions, particularly in children, are rare but should be considered in children with new-onset nail dystrophy." | 1.46 | Lichenoid Drug Eruption with Prominent Nail Changes Due to Leflunomide in a 12-Year-Old Child. ( Brandling-Bennett, HA; Cole, B; Fleckman, P; May, C; Sidbury, R, 2017) |
| "Four months later widespread prunosus skin rash appeared on her skin." | 1.35 | Severe cutaneous adverse drug reaction to leflunomide: a report of two cases. ( Guo, G; Jian, X; Li, X; Lin, D; Ruan, Y, 2008) |
| "Leflunomide is a new oral disease modifying antirheumatic drug with a good safety profile." | 1.33 | Lupus erythematosus with leflunomide: induction or reactivation? ( Gensburger, D; Kanitakis, J; Kawashima, M; Marotte, H; Miossec, P, 2005) |
| "Leflunomide is an antirheumatic agent of the type of a 'disease-modifying antirheumatic drug'." | 1.32 | Erythema multiforme-like drug eruption with oral involvement after intake of leflunomide. ( Barta, U; Bauer, HI; Elsner, P; Fischer, TW; Graefe, T, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (57.69) | 29.6817 |
| 2010's | 10 (38.46) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, YQ | 1 |
| Mu, ZL | 1 |
| Zhang, JZ | 1 |
| May, C | 1 |
| Fleckman, P | 1 |
| Brandling-Bennett, HA | 1 |
| Cole, B | 1 |
| Sidbury, R | 1 |
| Keeley, JM | 1 |
| Pavlidakey, P | 1 |
| Sami, N | 1 |
| Frances, L | 1 |
| Guijarro, J | 1 |
| Marin, I | 1 |
| Leiva-Salinas, Mdel C | 1 |
| Bouret, AM | 1 |
| Blasco-Morente, G | 1 |
| Notario-Ferreira, I | 1 |
| Rueda-Villafranca, B | 1 |
| Tercedor-Sánchez, J | 1 |
| Tidwell, WJ | 1 |
| Malone, J | 1 |
| Callen, JP | 1 |
| Schmutz, JL | 2 |
| Cornillier, H | 1 |
| Kervarrec, T | 1 |
| Tabareau-Delalande, F | 1 |
| Mammou, S | 1 |
| Jonville Bera, AP | 1 |
| Machet, L | 1 |
| Do-Pham, G | 1 |
| Charachon, A | 1 |
| Duong, TA | 1 |
| Thille, AW | 1 |
| Benhaiem, N | 1 |
| Bagot, M | 1 |
| Chosidow, O | 1 |
| Roujeau, JC | 1 |
| Wolkenstein, P | 1 |
| Valeyrie-Allanore, L | 1 |
| Savoia, F | 1 |
| Gaddoni, G | 1 |
| Casadio, C | 1 |
| Spadola, G | 1 |
| Patrizi, A | 1 |
| Giacomini, F | 1 |
| Aldi, M | 1 |
| Vaish, AK | 1 |
| Tripathi, AK | 1 |
| Gupta, LK | 1 |
| Jain, N | 1 |
| Agarwal, A | 1 |
| Verma, SK | 1 |
| Soliotis, F | 1 |
| Glover, M | 1 |
| Jawad, AS | 1 |
| Chan, AT | 1 |
| Bradlow, A | 1 |
| McNally, J | 1 |
| Mohty, R | 1 |
| Chaby, G | 1 |
| Pannier, M | 1 |
| Defossez, C | 1 |
| Denoeux, JP | 1 |
| Lok, C | 1 |
| Canonne-Courivaud, D | 1 |
| Carpentier, O | 1 |
| Dejobert, Y | 1 |
| Hachulla, E | 1 |
| Delaporte, E | 1 |
| Fischer, TW | 1 |
| Bauer, HI | 1 |
| Graefe, T | 1 |
| Barta, U | 1 |
| Elsner, P | 1 |
| Kerr, OA | 1 |
| Murray, CS | 1 |
| Tidman, MJ | 1 |
| Rivarola de Gutierrez, E | 1 |
| Abaca, H | 1 |
| Gensburger, D | 1 |
| Kawashima, M | 1 |
| Marotte, H | 1 |
| Kanitakis, J | 1 |
| Miossec, P | 1 |
| Kamata, Y | 1 |
| Nara, H | 1 |
| Kamimura, T | 1 |
| Haneda, K | 1 |
| Iwamoto, M | 1 |
| Masuyama, J | 1 |
| Okazaki, H | 1 |
| Minota, S | 1 |
| Barbaud, A | 1 |
| Trechot, P | 1 |
| Suzuki, Y | 1 |
| Saito, E | 1 |
| Wakabayashi, T | 1 |
| Suwa, A | 1 |
| Suess, A | 1 |
| Sticherling, M | 1 |
| Jian, X | 1 |
| Guo, G | 1 |
| Ruan, Y | 1 |
| Lin, D | 1 |
| Li, X | 1 |
| Kiely, PD | 1 |
| Johnson, DM | 1 |
3 reviews available for leflunomide and Dermatitis Medicamentosa
| Article | Year |
|---|---|
Perforating disorder secondary to leflunomide and review of the literature of medications associated with perforating disorder.
Topics: Adult; Drug Eruptions; Elastin; Epidermis; Female; Humans; Immunosuppressive Agents; Leflunomide; Sk | 2018 |
Severe skin reaction after leflunomide and etanercept in a patient with rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Drug Eruptions; Erythema; Etanercept; Female; Humans; Immunoglobulin G | 2002 |
[Adverse effects of conventional DMARDs and biologic DMARDs].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Chemical and Drug Induced Liver Injury; Cysteine; Drug | 2007 |
1 trial available for leflunomide and Dermatitis Medicamentosa
| Article | Year |
|---|---|
Infliximab and leflunomide combination therapy in rheumatoid arthritis: an open-label study.
Topics: Adult; Aged; Anaphylaxis; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoa | 2002 |
22 other studies available for leflunomide and Dermatitis Medicamentosa
| Article | Year |
|---|---|
Erythema multiforme-like drug eruption in a patient with systemic lupus erythematosus treated with leflunomide.
Topics: Drug Eruptions; Erythema Multiforme; Humans; Leflunomide; Lupus Erythematosus, Systemic | 2020 |
Lichenoid Drug Eruption with Prominent Nail Changes Due to Leflunomide in a 12-Year-Old Child.
Topics: Antirheumatic Agents; Child; Drug Eruptions; Female; Humans; Isoxazoles; Leflunomide; Lichenoid Erup | 2017 |
Multiple eruptive keratoacanthomas associated with leflunomide.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carcinoma, Squamous Cell; Drug | 2013 |
[Subacute cutaneous lupus erythematosus induced by golimumab].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Eruptions; Drug Therapy, C | 2015 |
Eruptive Keratoacanthomas Associated With Leflunomide.
Topics: Antirheumatic Agents; Drug Eruptions; Female; Humans; Isoxazoles; Keratoacanthoma; Leflunomide; Midd | 2016 |
[Eruptive keratoacanthomas and leflunomide].
Topics: Antirheumatic Agents; Drug Eruptions; Humans; Immunocompromised Host; Isoxazoles; Keratoacanthoma; L | 2016 |
Interstitial granulomatous dermatitis occurring in a patient with SAPHO syndrome one month after starting leflunomide, and subsequently disappearing with ustekinumab.
Topics: Acquired Hyperostosis Syndrome; Adult; Dermatitis; Dermatologic Agents; Drug Eruptions; Female; Gran | 2016 |
Drug reaction with eosinophilia and systemic symptoms and severe involvement of digestive tract: description of two cases.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anticonvulsants; Antirheumatic Agents; Colitis, Ulcerative; Dr | 2011 |
A case of eczematous and vesicular dermatitis during anti-TNFalpha therapy for rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnostic Errors; Drug Eruptions; Drug Synergis | 2011 |
An unusual case of DRESS syndrome due to leflunomide.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Candidiasis, Oral; Diagnosis, Differential; Drug Eru | 2011 |
Leflunomide induced vasculitis--a dose-response relationship.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Eruptions; Humans; Isoxazoles; Leflunomide; Male; Midd | 2003 |
[Drug hypersensitivity syndrome induced by leflunomide].
Topics: Arthritis, Rheumatoid; Drug Eruptions; Female; Humans; Immunosuppressive Agents; Isoxazoles; Lefluno | 2003 |
[Lichenoid drug reaction to leflunomide].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biopsy; Drug Eruptions; Female; Huma | 2003 |
Erythema multiforme-like drug eruption with oral involvement after intake of leflunomide.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Eruptions; Erythema Multiforme; | 2003 |
Subacute cutaneous lupus erythematosus associated with leflunomide.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Eruptions; Humans; Isoxazoles; | 2004 |
Photodistributed lichenoid drug eruption with rhabdomyolysis occurring during leflunomide therapy.
Topics: Abdominal Pain; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Eruptions; Fema | 2004 |
Lupus erythematosus with leflunomide: induction or reactivation?
Topics: Antirheumatic Agents; Drug Eruptions; Female; Humans; Isoxazoles; Leflunomide; Lupus Erythematosus, | 2005 |
Rheumatoid arthritis complicated with acute interstitial pneumonia induced by leflunomide as an adverse reaction.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Eruptions; Human | 2004 |
[Drug-induced lichenoid eruptions].
Topics: Drug Eruptions; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Lichenoid Erupti | 2006 |
Leflunomide in subacute cutaneous lupus erythematosus - two sides of a coin.
Topics: Adult; Aged; Antirheumatic Agents; Diagnosis, Differential; Drug Eruptions; Enzyme Inhibitors; Eryth | 2008 |
Severe cutaneous adverse drug reaction to leflunomide: a report of two cases.
Topics: Adolescent; Anti-Inflammatory Agents; Blister; Drug Eruptions; Exanthema; Female; Glucocorticoids; H | 2008 |
Cutaneous drug reaction case reports: from the world literature.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Capecitabine; Carbamates; Ceftriaxone; Clonidine; Deoxyc | 2002 |