leflunomide has been researched along with Delayed Hypersensitivity in 6 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| " One such medication applied in patients with rheumatoid arthritis is leflunomide." | 3.73 | Influence of leflunomide on gastrointestinal Candida albicans infection induced in naive and arthritic newborn mice. ( Dimitrova, P; Ivanovska, N, 2006) |
| " Drug studies were performed, using a 4-day dosing schedule, on optimal DTH elicited on day 10, suboptimal DTH elicited on day 15, and AA (day 16)." | 1.28 | Drug actions on delayed-type hypersensitivity in rats with developing and established adjuvant arthritis. ( Hambleton, P; McMahon, S, 1990) |
| "), dosed for 8 or 16 days beginning with the day of adjuvant administration, significantly reduced edema, fibrinogen levels, and erythrocyte sedimentation rates (ESR) 42 days later." | 1.27 | Disease modifying activity of HWA 486 in rat adjuvant-induced arthritis. ( Buyniski, JP; Gylys, JA; Pasternak, RD; Siminoff, P; Wadopian, NS; Wright, RN, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kuo, EA | 1 |
| Hambleton, PT | 1 |
| Kay, DP | 1 |
| Evans, PL | 1 |
| Matharu, SS | 1 |
| Little, E | 1 |
| McDowall, N | 1 |
| Jones, CB | 1 |
| Hedgecock, CJ | 1 |
| Yea, CM | 1 |
| Chan, AW | 1 |
| Hairsine, PW | 1 |
| Ager, IR | 1 |
| Tully, WR | 1 |
| Williamson, RA | 1 |
| Westwood, R | 1 |
| Dimitrova, P | 1 |
| Ivanovska, N | 1 |
| Di Pierro, F | 1 |
| d'Atri, G | 1 |
| Marcucci, F | 1 |
| Leoni, F | 1 |
| Schmidt, K | 1 |
| Bekemeier, H | 1 |
| Giessler, J | 1 |
| Pilopp, H | 1 |
| Hambleton, P | 1 |
| McMahon, S | 1 |
| Pasternak, RD | 1 |
| Wadopian, NS | 1 |
| Wright, RN | 1 |
| Siminoff, P | 1 |
| Gylys, JA | 1 |
| Buyniski, JP | 1 |
6 other studies available for leflunomide and Delayed Hypersensitivity
| Article | Year |
|---|---|
Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'-(trifluoromethyl)phenyl ] propenamide and related compounds.
Topics: Acrylamides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dihydroorota | 1996 |
Influence of leflunomide on gastrointestinal Candida albicans infection induced in naive and arthritic newborn mice.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Candida albicans; Candidiasis; Collagen; Colon | 2006 |
Use of type I and type IV hypersensitivity responses to define the immunopharmacological profile of drugs.
Topics: Animals; C-Reactive Protein; Cyclosporine; Drug Evaluation, Preclinical; Female; Hypersensitivity, D | 1997 |
Immunomodulating effects of T-44 in comparison to HWA 486.
Topics: 1-Naphthylamine; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclospor | 1991 |
Drug actions on delayed-type hypersensitivity in rats with developing and established adjuvant arthritis.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Bacterial; Art | 1990 |
Disease modifying activity of HWA 486 in rat adjuvant-induced arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Cyclosporins; | 1987 |