leflunomide has been researched along with Complications, Pregnancy in 14 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Leflunomide (LMF) is an immunemodulatory drug used in the therapy of Rheumatoid Arthritis (RA)." | 8.85 | Pregnancy course and neonatal outcome after exposure to leflunomide--2 cases report and review of literature. ( Banas, T; Batko, B; Górnisiewicz, T; Hajdyla-Banaś, I; Pityńska-Korab, E; Rydz-Stryszowska, I; Skura, A, 2009) |
| "Maternal exposure to leflunomide during pregnancy was not associated with statistically significant increased risk of MCMs, prematurity, LBW or spontaneous abortions." | 7.88 | Leflunomide use during pregnancy and the risk of adverse pregnancy outcomes. ( Bérard, A; Colilla, S; Shui, I; Zhao, JP, 2018) |
| "Sixty-four pregnant women with rheumatoid arthritis (RA) who were treated with leflunomide during pregnancy (95." | 7.76 | Birth outcomes in women who have taken leflunomide during pregnancy. ( Braddock, SR; Chambers, CD; Jin, S; Johnson, DL; Jones, KL; Lopez-Jimenez, J; Luo, YJ; Mirrasoul, N; Robinson, LK; Salas, E; Xu, R, 2010) |
| "Leflunomide is a new and effective disease-modifying antirheumatic drug." | 5.31 | Leflunomide: new antirheumatic drug. Effect on pregnancy outcomes. ( Koren, G; Kozer, E; Moretti, ME, 2001) |
| "A great body of evidence suggest that hydroxychloroquine, sulfasalazine, and non-fluorinated steroids can be continued throughout pregnancy, while methotrexate and leflunomide should be discontinued 3 months before pregnancy." | 4.93 | Challenges and treatment options for rheumatoid arthritis during pregnancy. ( Gerosa, M; Meroni, PL; Schioppo, T, 2016) |
| " Mycophenolate and leflunomide are teratogenic drugs and should be withdrawn before conception in case of programmed pregnancy or should be rapidly discontinued in case of unexpected pregnancy." | 4.91 | Immunosuppression in pregnant women with systemic lupus erythematosus. ( Moroni, G; Ponticelli, C, 2015) |
| " The earlier use of methotrexate and the introduction of tumor necrosis factor-alpha inhibitors in the treatment of rheumatoid arthritis have changed the natural characteristics of the disease." | 4.87 | [Systemic autoimmune disorders and pregnancy]. ( Kiss, CG; Kiss, E; Poór, G, 2011) |
| "Leflunomide (LMF) is an immunemodulatory drug used in the therapy of Rheumatoid Arthritis (RA)." | 4.85 | Pregnancy course and neonatal outcome after exposure to leflunomide--2 cases report and review of literature. ( Banas, T; Batko, B; Górnisiewicz, T; Hajdyla-Banaś, I; Pityńska-Korab, E; Rydz-Stryszowska, I; Skura, A, 2009) |
| "The widely accepted standard therapy for cutaneous sarcoidosis includes corticosteroids, antimalarials, and methotrexate." | 4.84 | Cutaneous sarcoidosis therapy updated. ( Badgwell, C; Rosen, T, 2007) |
| "Maternal exposure to leflunomide during pregnancy was not associated with statistically significant increased risk of MCMs, prematurity, LBW or spontaneous abortions." | 3.88 | Leflunomide use during pregnancy and the risk of adverse pregnancy outcomes. ( Bérard, A; Colilla, S; Shui, I; Zhao, JP, 2018) |
| "Sixty-four pregnant women with rheumatoid arthritis (RA) who were treated with leflunomide during pregnancy (95." | 3.76 | Birth outcomes in women who have taken leflunomide during pregnancy. ( Braddock, SR; Chambers, CD; Jin, S; Johnson, DL; Jones, KL; Lopez-Jimenez, J; Luo, YJ; Mirrasoul, N; Robinson, LK; Salas, E; Xu, R, 2010) |
| "To describe the practices of rheumatologists when prescribing the disease modifying antirheumatic drugs (DMARD) methotrexate (MTX), leflunomide (LF), etanercept (ET), and infliximab (IN) to women of childbearing age with rheumatoid arthritis (RA) and the pregnancy outcomes of patients who become pregnant while taking these medications." | 3.72 | The use of disease modifying antirheumatic drugs in women with rheumatoid arthritis of childbearing age: a survey of practice patterns and pregnancy outcomes. ( Bush, TM; Chakravarty, EF; Sanchez-Yamamoto, D, 2003) |
| "Psoriatic arthritis may be treated during pregnancy with glucocorticosteroids, especially with prednisone or prednisolone." | 1.36 | [Active psoriatic arthritis during pregnancy: challenges and limitations of pharmacotherapy]. ( Matuszewska, A; Misterska-Skóra, M; Wiland, P, 2010) |
| "Leflunomide is a new and effective disease-modifying antirheumatic drug." | 1.31 | Leflunomide: new antirheumatic drug. Effect on pregnancy outcomes. ( Koren, G; Kozer, E; Moretti, ME, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Rebić, N | 1 |
| Sayre, EC | 1 |
| Zusman, EZ | 1 |
| Amiri, N | 1 |
| Baldwin, C | 1 |
| De Vera, MA | 1 |
| Hammad, I | 1 |
| Porter, TF | 1 |
| Bérard, A | 1 |
| Zhao, JP | 1 |
| Shui, I | 1 |
| Colilla, S | 1 |
| Ponticelli, C | 1 |
| Moroni, G | 1 |
| Gerosa, M | 1 |
| Schioppo, T | 1 |
| Meroni, PL | 1 |
| Østensen, M | 1 |
| Förger, F | 1 |
| Chambers, CD | 1 |
| Johnson, DL | 1 |
| Robinson, LK | 1 |
| Braddock, SR | 1 |
| Xu, R | 1 |
| Lopez-Jimenez, J | 1 |
| Mirrasoul, N | 1 |
| Salas, E | 1 |
| Luo, YJ | 1 |
| Jin, S | 1 |
| Jones, KL | 2 |
| Hajdyla-Banaś, I | 1 |
| Banas, T | 1 |
| Rydz-Stryszowska, I | 1 |
| Batko, B | 1 |
| Skura, A | 1 |
| Górnisiewicz, T | 1 |
| Pityńska-Korab, E | 1 |
| Matuszewska, A | 1 |
| Misterska-Skóra, M | 1 |
| Wiland, P | 1 |
| Kiss, E | 1 |
| Kiss, CG | 1 |
| Poór, G | 1 |
| Chakravarty, EF | 1 |
| Sanchez-Yamamoto, D | 1 |
| Bush, TM | 1 |
| Badgwell, C | 1 |
| Rosen, T | 1 |
| Chambers, C | 1 |
| Koren, G | 2 |
| Tutuncu, ZN | 1 |
| Johnson, D | 1 |
| Kozer, E | 1 |
| Moretti, ME | 1 |
8 reviews available for leflunomide and Complications, Pregnancy
| Article | Year |
|---|---|
An Update on Biologic Agents During Pregnancy.
Topics: Abnormalities, Drug-Induced; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humani | 2020 |
Immunosuppression in pregnant women with systemic lupus erythematosus.
Topics: Contraindications; Cyclosporine; Female; Glucocorticoids; Humans; Hypertension; Immunosuppression Th | 2015 |
Challenges and treatment options for rheumatoid arthritis during pregnancy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Hydroxychloroquine | 2016 |
Management of RA medications in pregnant patients.
Topics: Abatacept; Acetaminophen; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoc | 2009 |
Pregnancy course and neonatal outcome after exposure to leflunomide--2 cases report and review of literature.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Infant | 2009 |
[Systemic autoimmune disorders and pregnancy].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Antiphospholipid Syndrome; Arthrit | 2011 |
Cutaneous sarcoidosis therapy updated.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Allopurinol; Animals; Anti-Inflammatory Agents | 2007 |
Are new agents used to treat rheumatoid arthritis safe to take during pregnancy? Organization of Teratology Information Specialists (OTIS) study.
Topics: Abnormalities, Drug-Induced; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprin | 2007 |
6 other studies available for leflunomide and Complications, Pregnancy
| Article | Year |
|---|---|
Perinatal use and discontinuation of disease-modifying anti-rheumatic drugs and biologics in women with rheumatoid arthritis: a cohort study.
Topics: Abatacept; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Antirh | 2020 |
Leflunomide use during pregnancy and the risk of adverse pregnancy outcomes.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Antirheumatic Agents; Female; Humans; Inf | 2018 |
Birth outcomes in women who have taken leflunomide during pregnancy.
Topics: Adult; Anticholesteremic Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Birth Weight; Body Siz | 2010 |
[Active psoriatic arthritis during pregnancy: challenges and limitations of pharmacotherapy].
Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Contraindications; Cyclosporine; Female; Humans; | 2010 |
The use of disease modifying antirheumatic drugs in women with rheumatoid arthritis of childbearing age: a survey of practice patterns and pregnancy outcomes.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Attitude of Health Perso | 2003 |
Leflunomide: new antirheumatic drug. Effect on pregnancy outcomes.
Topics: Abnormalities, Drug-Induced; Adult; Arthritis, Rheumatoid; Female; Half-Life; Humans; Immunosuppress | 2001 |