leflunomide has been researched along with Colorectal Cancer in 2 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Colorectal cancer has provided an important model to test the stem cell hypothesis of cancer origin, which implies that cancer arises as a result of genetic aberrations in stem cells leading to deregulation of the proliferation/differentiation balance." | 1.36 | Survivin is regulated by interleukin-4 in colon cancer stem cells. ( Di Stefano, AB; Dieli, F; Eterno, V; Höger, T; Iovino, F; Lombardo, Y; Stassi, G; Todaro, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Di Stefano, AB | 1 |
| Iovino, F | 1 |
| Lombardo, Y | 1 |
| Eterno, V | 1 |
| Höger, T | 1 |
| Dieli, F | 1 |
| Stassi, G | 1 |
| Todaro, M | 1 |
| Casadio, F | 1 |
| Croci, S | 1 |
| D'Errico Grigioni, A | 1 |
| Corti, B | 1 |
| Grigioni, WF | 1 |
| Landuzzi, L | 1 |
| Lollini, PL | 1 |
2 other studies available for leflunomide and Colorectal Cancer
| Article | Year |
|---|---|
Survivin is regulated by interleukin-4 in colon cancer stem cells.
Topics: Antineoplastic Agents; Apoptosis; Colorectal Neoplasms; Fluorescent Antibody Technique; Gene Express | 2010 |
Toward the definition of immunosuppressive regimens with antitumor activity.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Survival; Colore | 2005 |