leflunomide has been researched along with Colitis, Granulomatous in 5 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The primary end point was steroid-free remission, and secondary end points were changes in the Crohn's disease activity index (CDAI) and steroid intake, responsiveness of arthralgias and adverse events." | 2.73 | Treatment of Crohn's disease with leflunomide as second-line immunosuppression : a phase 1 open-label trial on efficacy, tolerability and safety. ( Galle, PR; Gerts, AL; Holtmann, MH; Neurath, MF; Weinman, A, 2008) |
| "Leflunomide was well tolerated and resulted in a significant reduction in the H-B score, global assessment and serologic parameters in 8/12 patients." | 1.32 | Leflunomide treatment of Crohn's disease patients intolerant to standard immunomodulator therapy. ( Binion, DG; Csuka, ME; Emmons, J; Knox, JF; Prajapati, DN; Saeian, K, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Broekaert, IJ | 3 |
| Klein, A | 3 |
| Windschall, D | 3 |
| Rogalski, B | 3 |
| Weller-Heinemann, F | 3 |
| Oommen, P | 3 |
| Küster, M | 3 |
| Foeldvari, I | 3 |
| Minden, K | 3 |
| Hospach, A | 3 |
| Hufnagel, M | 3 |
| Berger, T | 3 |
| Geikowski, T | 3 |
| Quietzsch, J | 3 |
| Horneff, G | 3 |
| Sachar, DB | 1 |
| Prajapati, DN | 1 |
| Knox, JF | 1 |
| Emmons, J | 1 |
| Saeian, K | 1 |
| Csuka, ME | 1 |
| Binion, DG | 1 |
| Thielen, AM | 1 |
| Barde, C | 1 |
| Janer, V | 1 |
| Borradori, L | 1 |
| Saurat, JH | 1 |
| Holtmann, MH | 1 |
| Gerts, AL | 1 |
| Weinman, A | 1 |
| Galle, PR | 1 |
| Neurath, MF | 1 |
1 trial available for leflunomide and Colitis, Granulomatous
| Article | Year |
|---|---|
Treatment of Crohn's disease with leflunomide as second-line immunosuppression : a phase 1 open-label trial on efficacy, tolerability and safety.
Topics: Adult; Anti-Inflammatory Agents; Crohn Disease; Drug Therapy, Combination; Female; Follow-Up Studies | 2008 |
4 other studies available for leflunomide and Colitis, Granulomatous
| Article | Year |
|---|---|
Development of Inflammatory Bowel Disease in Children With Juvenile Idiopathic Arthritis Treated With Biologics.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Biological Products; Child; Colitis, Ulcerative; Crohn Di | 2023 |
Development of Inflammatory Bowel Disease in Children With Juvenile Idiopathic Arthritis Treated With Biologics.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Biological Products; Child; Colitis, Ulcerative; Crohn Di | 2023 |
Development of Inflammatory Bowel Disease in Children With Juvenile Idiopathic Arthritis Treated With Biologics.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Biological Products; Child; Colitis, Ulcerative; Crohn Di | 2023 |
Development of Inflammatory Bowel Disease in Children With Juvenile Idiopathic Arthritis Treated With Biologics.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Biological Products; Child; Colitis, Ulcerative; Crohn Di | 2023 |
Development of Inflammatory Bowel Disease in Children With Juvenile Idiopathic Arthritis Treated With Biologics.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Biological Products; Child; Colitis, Ulcerative; Crohn Di | 2023 |
Development of Inflammatory Bowel Disease in Children With Juvenile Idiopathic Arthritis Treated With Biologics.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Biological Products; Child; Colitis, Ulcerative; Crohn Di | 2023 |
Development of Inflammatory Bowel Disease in Children With Juvenile Idiopathic Arthritis Treated With Biologics.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Biological Products; Child; Colitis, Ulcerative; Crohn Di | 2023 |
Development of Inflammatory Bowel Disease in Children With Juvenile Idiopathic Arthritis Treated With Biologics.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Biological Products; Child; Colitis, Ulcerative; Crohn Di | 2023 |
Development of Inflammatory Bowel Disease in Children With Juvenile Idiopathic Arthritis Treated With Biologics.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Biological Products; Child; Colitis, Ulcerative; Crohn Di | 2023 |
Leflunomide in Crohn's disease--the open-label case series and the Texas sharpshooter.
Topics: Crohn Disease; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Treatment Outcome | 2003 |
Leflunomide treatment of Crohn's disease patients intolerant to standard immunomodulator therapy.
Topics: Adjuvants, Immunologic; Adult; Aged; Crohn Disease; Female; Humans; Immunosuppressive Agents; Isoxaz | 2003 |
Reiter syndrome triggered by adalimumab (Humira) and leflunomide (Arava) in a patient with ankylosing spondylarthropathy and Crohn disease.
Topics: Adalimumab; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Mono | 2007 |