leflunomide has been researched along with Chronic Lung Injury in 5 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 12 patients, lung injury developed even 2 months after leflunomide withdrawal." | 5.35 | Proposals for leflunomide use to avoid lung injury in patients with rheumatoid arthritis. ( Inokuma, S; Matsuda, T; Ohtsuka, T; Saeki, Y; Sagawa, A; Sato, T; Sawada, T; Takemura, T; Takeuchi, T, 2008) |
| "The changes of plasma dihydrorhodamine 123 oxidation level, the myeloperoxidase activity, and extravasations of Evans blue dye of lung in wild-type mice with or without c-Jun NH2-terminal kinase inhibitor; c-Jun NH2-terminal kinase1 mice and c-Jun NH2-terminal kinase1 mice; and chimeric mice (wild-type --> wild-type, c-Jun NH2-terminal kinase1 --> wild-type) with Pseudomonas aeruginosa-induced peritonitis were determined to evaluate the role of c-Jun NH2-terminal kinase signaling of the hematopoietic cells in peritonitis-induced lung damage." | 3.76 | Peritonitis-induced peroxynitrite and lung damage depends on c-Jun NH2-terminal kinase signaling of hematopoietic cells. ( Chen, LW; Chen, PH; Hsu, CM; Tseng, HT, 2010) |
| "The pathogenesis of DMARD-induced lung injury may have common features that need to be clarified in the future." | 2.47 | Leflunomide-induced interstitial pneumonitis might be a representative of disease-modifying antirheumatic drug-induced lung injury. ( Inokuma, S, 2011) |
| "In 12 patients, lung injury developed even 2 months after leflunomide withdrawal." | 1.35 | Proposals for leflunomide use to avoid lung injury in patients with rheumatoid arthritis. ( Inokuma, S; Matsuda, T; Ohtsuka, T; Saeki, Y; Sagawa, A; Sato, T; Sawada, T; Takemura, T; Takeuchi, T, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Inokuma, S | 3 |
| Sato, T | 2 |
| Sagawa, A | 2 |
| Matsuda, T | 2 |
| Takemura, T | 2 |
| Ohtsuka, T | 1 |
| Saeki, Y | 2 |
| Takeuchi, T | 2 |
| Sawada, T | 2 |
| Otsuka, T | 1 |
| Chen, LW | 1 |
| Tseng, HT | 1 |
| Chen, PH | 1 |
| Hsu, CM | 1 |
| McLaren, ZL | 1 |
| Dawson, JK | 1 |
1 review available for leflunomide and Chronic Lung Injury
| Article | Year |
|---|---|
Leflunomide-induced interstitial pneumonitis might be a representative of disease-modifying antirheumatic drug-induced lung injury.
Topics: Animals; Antirheumatic Agents; Humans; Isoxazoles; Japan; Leflunomide; Lung Diseases, Interstitial; | 2011 |
4 other studies available for leflunomide and Chronic Lung Injury
| Article | Year |
|---|---|
Proposals for leflunomide use to avoid lung injury in patients with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Japan; Leflunomide; L | 2008 |
Factors associated with fatal outcome of leflunomide-induced lung injury in Japanese patients with rheumatoid arthritis.
Topics: Aged; Aniline Compounds; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Crotonates | 2009 |
Peritonitis-induced peroxynitrite and lung damage depends on c-Jun NH2-terminal kinase signaling of hematopoietic cells.
Topics: Animals; Anthracenes; Blotting, Western; Dimethyl Sulfoxide; Disease Models, Animal; Hematopoiesis; | 2010 |
Comment on: Factors associated with fatal outcome of leflunomide-induced lung injury in Japanese patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Cause of Death; Humans; Isoxazoles; Japan | 2010 |