Page last updated: 2024-10-30

leflunomide and Chronic Lung Injury

leflunomide has been researched along with Chronic Lung Injury in 5 studies

Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Research Excerpts

ExcerptRelevanceReference
"In 12 patients, lung injury developed even 2 months after leflunomide withdrawal."5.35Proposals for leflunomide use to avoid lung injury in patients with rheumatoid arthritis. ( Inokuma, S; Matsuda, T; Ohtsuka, T; Saeki, Y; Sagawa, A; Sato, T; Sawada, T; Takemura, T; Takeuchi, T, 2008)
"The changes of plasma dihydrorhodamine 123 oxidation level, the myeloperoxidase activity, and extravasations of Evans blue dye of lung in wild-type mice with or without c-Jun NH2-terminal kinase inhibitor; c-Jun NH2-terminal kinase1 mice and c-Jun NH2-terminal kinase1 mice; and chimeric mice (wild-type --> wild-type, c-Jun NH2-terminal kinase1 --> wild-type) with Pseudomonas aeruginosa-induced peritonitis were determined to evaluate the role of c-Jun NH2-terminal kinase signaling of the hematopoietic cells in peritonitis-induced lung damage."3.76Peritonitis-induced peroxynitrite and lung damage depends on c-Jun NH2-terminal kinase signaling of hematopoietic cells. ( Chen, LW; Chen, PH; Hsu, CM; Tseng, HT, 2010)
"The pathogenesis of DMARD-induced lung injury may have common features that need to be clarified in the future."2.47Leflunomide-induced interstitial pneumonitis might be a representative of disease-modifying antirheumatic drug-induced lung injury. ( Inokuma, S, 2011)
"In 12 patients, lung injury developed even 2 months after leflunomide withdrawal."1.35Proposals for leflunomide use to avoid lung injury in patients with rheumatoid arthritis. ( Inokuma, S; Matsuda, T; Ohtsuka, T; Saeki, Y; Sagawa, A; Sato, T; Sawada, T; Takemura, T; Takeuchi, T, 2008)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Inokuma, S3
Sato, T2
Sagawa, A2
Matsuda, T2
Takemura, T2
Ohtsuka, T1
Saeki, Y2
Takeuchi, T2
Sawada, T2
Otsuka, T1
Chen, LW1
Tseng, HT1
Chen, PH1
Hsu, CM1
McLaren, ZL1
Dawson, JK1

Reviews

1 review available for leflunomide and Chronic Lung Injury

ArticleYear
Leflunomide-induced interstitial pneumonitis might be a representative of disease-modifying antirheumatic drug-induced lung injury.
    Expert opinion on drug safety, 2011, Volume: 10, Issue:4

    Topics: Animals; Antirheumatic Agents; Humans; Isoxazoles; Japan; Leflunomide; Lung Diseases, Interstitial;

2011

Other Studies

4 other studies available for leflunomide and Chronic Lung Injury

ArticleYear
Proposals for leflunomide use to avoid lung injury in patients with rheumatoid arthritis.
    Modern rheumatology, 2008, Volume: 18, Issue:5

    Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Japan; Leflunomide; L

2008
Factors associated with fatal outcome of leflunomide-induced lung injury in Japanese patients with rheumatoid arthritis.
    Rheumatology (Oxford, England), 2009, Volume: 48, Issue:10

    Topics: Aged; Aniline Compounds; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Crotonates

2009
Peritonitis-induced peroxynitrite and lung damage depends on c-Jun NH2-terminal kinase signaling of hematopoietic cells.
    Critical care medicine, 2010, Volume: 38, Issue:4

    Topics: Animals; Anthracenes; Blotting, Western; Dimethyl Sulfoxide; Disease Models, Animal; Hematopoiesis;

2010
Comment on: Factors associated with fatal outcome of leflunomide-induced lung injury in Japanese patients with rheumatoid arthritis.
    Rheumatology (Oxford, England), 2010, Volume: 49, Issue:8

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Cause of Death; Humans; Isoxazoles; Japan

2010