leflunomide has been researched along with Chondrodysplasia Punctata in 1 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Chondrodysplasia Punctata: A heterogeneous group of bone dysplasias, the common character of which is stippling of the epiphyses in infancy. The group includes a severe autosomal recessive form (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC), an autosomal dominant form (Conradi-Hunermann syndrome), and a milder X-linked form. Metabolic defects associated with impaired peroxisomes are present only in the rhizomelic form.
| Excerpt | Relevance | Reference |
|---|---|---|
| "All 16 of the pregnancies with leflunomide exposure during pregnancy and 27 (93%) of the pregnancies with exposure prior to conception resulted in liveborn infants." | 7.78 | Pregnancy outcome in women exposed to leflunomide before or during pregnancy. ( Braddock, SR; Cassina, M; Chambers, CD; Jimenez, JL; Johnson, DL; Jones, KL; Luo, YJ; Mirrasoul, N; Robinson, LK; Salas, E; Xu, R, 2012) |
| "All 16 of the pregnancies with leflunomide exposure during pregnancy and 27 (93%) of the pregnancies with exposure prior to conception resulted in liveborn infants." | 3.78 | Pregnancy outcome in women exposed to leflunomide before or during pregnancy. ( Braddock, SR; Cassina, M; Chambers, CD; Jimenez, JL; Johnson, DL; Jones, KL; Luo, YJ; Mirrasoul, N; Robinson, LK; Salas, E; Xu, R, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cassina, M | 1 |
| Johnson, DL | 1 |
| Robinson, LK | 1 |
| Braddock, SR | 1 |
| Xu, R | 1 |
| Jimenez, JL | 1 |
| Mirrasoul, N | 1 |
| Salas, E | 1 |
| Luo, YJ | 1 |
| Jones, KL | 1 |
| Chambers, CD | 1 |
1 other study available for leflunomide and Chondrodysplasia Punctata
| Article | Year |
|---|---|
Pregnancy outcome in women exposed to leflunomide before or during pregnancy.
Topics: Abnormalities, Drug-Induced; Antirheumatic Agents; Chondrodysplasia Punctata; Ductus Arteriosus, Pat | 2012 |