leflunomide has been researched along with Chemical and Drug Induced Liver Injury, Chronic in 3 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Chemical and Drug Induced Liver Injury, Chronic: Liver disease lasting six months or more, caused by an adverse effect of a drug or chemical. The adverse effect may be caused by drugs, drug metabolites, chemicals from the environment, or an idiosyncratic response.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Devarbhavi, H | 1 |
| Ghabril, M | 1 |
| Barnhart, H | 1 |
| Patil, M | 1 |
| Raj, S | 1 |
| Gu, J | 1 |
| Chalasani, N | 1 |
| Bonkovsky, HL | 1 |
| Sokar, SS | 1 |
| Alkabbani, MA | 1 |
| Akool, ES | 1 |
| Abu-Risha, SE | 1 |
| Legras, A | 1 |
| Bergemer-Fouquet, AM | 1 |
| Jonville-Bera, AP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Center, Longitudinal Study of Drug-and CAM-Induced Liver Injury[NCT00345930] | 4,000 participants (Anticipated) | Observational | 2004-09-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for leflunomide and Chemical and Drug Induced Liver Injury, Chronic
| Article | Year |
|---|---|
Leflunomide-induced liver injury: Differences in characteristics and outcomes in Indian and US registries.
Topics: Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Drug-Relate | 2022 |
Hepatoprotective effects of carvedilol and crocin against leflunomide-induced liver injury.
Topics: Animals; Carvedilol; Catalase; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 2022 |
Fatal hepatitis with leflunomide and itraconazole.
Topics: Aged; Antifungal Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury, Chronic; Dia | 2002 |