leflunomide has been researched along with Cell Transformation, Neoplastic in 1 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with leflunomide, a potent activator of mitochondrial fusion proteins, overcame inhibitory effects of fission on migration, signaling, and metastasis." | 1.56 | Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer. ( Bevoor, A; Boppisetti, J; Buschhaus, JM; Chen, YC; Chiang, B; Cutter, AC; Eckley, S; Ghosh, P; Haley, HR; Humphries, BA; Lahann, J; Luker, GD; Luker, KE; Neale, DB; Palagama, DSW; Qyli, T; Robison, TH; Ross, BD; Sahoo, D; Sahoo, S; Spinosa, PC; Yoon, E, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Humphries, BA | 1 |
| Cutter, AC | 1 |
| Buschhaus, JM | 1 |
| Chen, YC | 1 |
| Qyli, T | 1 |
| Palagama, DSW | 1 |
| Eckley, S | 1 |
| Robison, TH | 1 |
| Bevoor, A | 1 |
| Chiang, B | 1 |
| Haley, HR | 1 |
| Sahoo, S | 1 |
| Spinosa, PC | 1 |
| Neale, DB | 1 |
| Boppisetti, J | 1 |
| Sahoo, D | 1 |
| Ghosh, P | 1 |
| Lahann, J | 1 |
| Ross, BD | 1 |
| Yoon, E | 1 |
| Luker, KE | 1 |
| Luker, GD | 1 |
1 other study available for leflunomide and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer.
Topics: Animals; Bone Neoplasms; Carboxy-Lyases; Cell Transformation, Neoplastic; Female; Humans; Immunosupp | 2020 |