leflunomide has been researched along with Asthma in 3 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with leflunomide in vivo prevented allergen-induced mast cell degranulation in vitro because the mast cells lacked IgE on their surface." | 5.30 | Leflunomide, a novel immunomodulating agent, prevents the development of allergic sensitization in an animal model of allergic asthma. ( Eber, E; McMenamin, C; Sly, PD; Uhlig, T, 1998) |
| "Treatment with leflunomide in vivo prevented allergen-induced mast cell degranulation in vitro because the mast cells lacked IgE on their surface." | 1.30 | Leflunomide, a novel immunomodulating agent, prevents the development of allergic sensitization in an animal model of allergic asthma. ( Eber, E; McMenamin, C; Sly, PD; Uhlig, T, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chiba, Y | 1 |
| Nakazawa, S | 1 |
| Todoroki, M | 1 |
| Shinozaki, K | 1 |
| Sakai, H | 1 |
| Misawa, M | 1 |
| Eber, E | 2 |
| Uhlig, T | 2 |
| McMenamin, C | 2 |
| Sly, PD | 2 |
| Cooper, D | 1 |
| Wildhaber, JH | 1 |
3 other studies available for leflunomide and Asthma
| Article | Year |
|---|---|
Interleukin-13 augments bronchial smooth muscle contractility with an up-regulation of RhoA protein.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchoalveolar Lavage; Cell Line; Disease | 2009 |
Leflunomide, a novel immunomodulating agent, prevents the development of allergic sensitization in an animal model of allergic asthma.
Topics: Allergens; Animals; Asthma; Bronchial Provocation Tests; Cell Degranulation; Dimercaprol; Disease Mo | 1998 |
Effects of long-term oral treatment with leflunomide on allergic sensitization, lymphocyte activation, and airway inflammation in a rat model of asthma.
Topics: Administration, Inhalation; Administration, Oral; Age Factors; Animals; Anti-Inflammatory Agents; An | 1998 |