leflunomide has been researched along with Asthma, Bronchial in 3 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Excerpt | Relevance | Reference |
---|---|---|
"Treatment with leflunomide in vivo prevented allergen-induced mast cell degranulation in vitro because the mast cells lacked IgE on their surface." | 5.30 | Leflunomide, a novel immunomodulating agent, prevents the development of allergic sensitization in an animal model of allergic asthma. ( Eber, E; McMenamin, C; Sly, PD; Uhlig, T, 1998) |
"Treatment with leflunomide in vivo prevented allergen-induced mast cell degranulation in vitro because the mast cells lacked IgE on their surface." | 1.30 | Leflunomide, a novel immunomodulating agent, prevents the development of allergic sensitization in an animal model of allergic asthma. ( Eber, E; McMenamin, C; Sly, PD; Uhlig, T, 1998) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (66.67) | 18.2507 |
2000's | 1 (33.33) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Chiba, Y | 1 |
Nakazawa, S | 1 |
Todoroki, M | 1 |
Shinozaki, K | 1 |
Sakai, H | 1 |
Misawa, M | 1 |
Eber, E | 2 |
Uhlig, T | 2 |
McMenamin, C | 2 |
Sly, PD | 2 |
Cooper, D | 1 |
Wildhaber, JH | 1 |
3 other studies available for leflunomide and Asthma, Bronchial
Article | Year |
---|---|
Interleukin-13 augments bronchial smooth muscle contractility with an up-regulation of RhoA protein.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchoalveolar Lavage; Cell Line; Disease | 2009 |
Leflunomide, a novel immunomodulating agent, prevents the development of allergic sensitization in an animal model of allergic asthma.
Topics: Allergens; Animals; Asthma; Bronchial Provocation Tests; Cell Degranulation; Dimercaprol; Disease Mo | 1998 |
Effects of long-term oral treatment with leflunomide on allergic sensitization, lymphocyte activation, and airway inflammation in a rat model of asthma.
Topics: Administration, Inhalation; Administration, Oral; Age Factors; Animals; Anti-Inflammatory Agents; An | 1998 |