leflunomide has been researched along with Arthritis, Degenerative in 4 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with treated hypertension should be monitored regularly when conventional NSAIDs or COX-2 inhibitors are administered." | 2.41 | Cardiovascular risk profile of antirheumatic agents in patients with osteoarthritis and rheumatoid arthritis. ( Dijkmans, BA; Nurmohamed, MT; van Halm, VP, 2002) |
| "Leflunomide was not able to abolish expression of metallo-proteinases in synoviocytes activated with TNF-a and IL-17." | 1.33 | The active form of leflunomide, HMR1726, facilitates TNF-alpha and IL-17 induced MMP-1 and MMP-3 expression. ( Abruzzese, T; Aicher, WK; Alexander, D; Friedrich, B; Gondolph-Zink, B; Wülker, N, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nurmohamed, MT | 1 |
| van Halm, VP | 1 |
| Dijkmans, BA | 1 |
| Takayanagi, H | 1 |
| Alexander, D | 1 |
| Friedrich, B | 1 |
| Abruzzese, T | 1 |
| Gondolph-Zink, B | 1 |
| Wülker, N | 1 |
| Aicher, WK | 1 |
| Wildy, KS | 1 |
| Wasko, MC | 1 |
3 reviews available for leflunomide and Arthritis, Degenerative
| Article | Year |
|---|---|
Cardiovascular risk profile of antirheumatic agents in patients with osteoarthritis and rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular | 2002 |
Inflammatory bone destruction and osteoimmunology.
Topics: Animals; Calcium Signaling; Carrier Proteins; Cell Differentiation; DNA-Binding Proteins; Enzyme Inh | 2005 |
Current concepts regarding pharmacologic treatment of rheumatoid and osteoarthritis.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumat | 2001 |
1 other study available for leflunomide and Arthritis, Degenerative
| Article | Year |
|---|---|
The active form of leflunomide, HMR1726, facilitates TNF-alpha and IL-17 induced MMP-1 and MMP-3 expression.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Arthritis, Rheumatoid; Cell Surviva | 2006 |