leflunomide has been researched along with Alveolitis, Fibrosing in 3 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 60-year-old rheumatoid arthritis (RA) female with lung fibrosis was treated with leflunomide (LEF) for only 12 days, and responded well." | 3.74 | Leflunomide-induced lung injury that developed after its withdrawal, coinciding with peripheral blood lymphocyte count decrease. ( Harada, M; Inokuma, S; Koyama, T; Niiro, H; Ohtani, R; Otsuka, T; Yoshizawa, S, 2008) |
| "Treatment with leflunomide, which reduces mitochondrial reactive oxygen species production and tyrosine phosphorylation, inhibits jmjd3 expression and M2 polarization, as well as development of a fibrotic phenotype." | 1.43 | Cu,Zn-Superoxide Dismutase-Mediated Redox Regulation of Jumonji Domain Containing 3 Modulates Macrophage Polarization and Pulmonary Fibrosis. ( Carter, AB; Gu, L; He, C; Larson-Casey, JL; Murthy, S; Ryan, AJ, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morin, F | 1 |
| Kavian, N | 1 |
| Chouzenoux, S | 1 |
| Cerles, O | 1 |
| Nicco, C | 1 |
| Chéreau, C | 1 |
| Batteux, F | 1 |
| He, C | 1 |
| Larson-Casey, JL | 1 |
| Gu, L | 1 |
| Ryan, AJ | 1 |
| Murthy, S | 1 |
| Carter, AB | 1 |
| Otsuka, T | 1 |
| Koyama, T | 1 |
| Ohtani, R | 1 |
| Niiro, H | 1 |
| Yoshizawa, S | 1 |
| Harada, M | 1 |
| Inokuma, S | 1 |
3 other studies available for leflunomide and Alveolitis, Fibrosing
| Article | Year |
|---|---|
Leflunomide prevents ROS-induced systemic fibrosis in mice.
Topics: Animals; Antirheumatic Agents; Autoantibodies; Bleomycin; Cells, Cultured; Disease Models, Animal; F | 2017 |
Cu,Zn-Superoxide Dismutase-Mediated Redox Regulation of Jumonji Domain Containing 3 Modulates Macrophage Polarization and Pulmonary Fibrosis.
Topics: Animals; Cell Line; Cell Polarity; Gene Expression Regulation; Humans; Interleukin-4; Isoxazoles; Ju | 2016 |
Leflunomide-induced lung injury that developed after its withdrawal, coinciding with peripheral blood lymphocyte count decrease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Administration Schedule; Female | 2008 |