leflunomide has been researched along with Acute Symptom Flare in 2 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 10-year-old girl with juvenile idiopathic arthritis in remission presented with a flare of her arthritis." | 1.48 | Juvenile idiopathic arthritis flare due to rice bodies in the knee of a 10-year-old girl. ( Barrow, M; Faller, G; Haagensen, M, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lillegraven, S | 1 |
| Paulshus Sundlisæter, N | 1 |
| Aga, AB | 1 |
| Sexton, J | 1 |
| Olsen, IC | 1 |
| Fremstad, H | 1 |
| Spada, C | 1 |
| Madland, TM | 1 |
| Høili, CA | 1 |
| Bakland, G | 1 |
| Lexberg, Å | 1 |
| Hansen, IJW | 1 |
| Hansen, IM | 1 |
| Haukeland, H | 1 |
| Ljoså, MA | 1 |
| Moholt, E | 1 |
| Uhlig, T | 1 |
| Solomon, DH | 1 |
| van der Heijde, D | 1 |
| Kvien, TK | 1 |
| Haavardsholm, EA | 1 |
| Faller, G | 1 |
| Haagensen, M | 1 |
| Barrow, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| REmission in Rheumatoid Arthritis - Assessing WIthrawal of Disease-modifying Antirheumatic Drugs in a Non-inferiority Design[NCT01881308] | Phase 4 | 320 participants (Actual) | Interventional | 2013-06-17 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for leflunomide and Acute Symptom Flare
| Article | Year |
|---|---|
Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug The | 2021 |
1 other study available for leflunomide and Acute Symptom Flare
| Article | Year |
|---|---|
Juvenile idiopathic arthritis flare due to rice bodies in the knee of a 10-year-old girl.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, | 2018 |