leflunomide has been researched along with Ache in 5 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the effectiveness, safety and cost implications of leflunomide treatment for rheumatoid arthritis." | 8.80 | Leflunomide and rheumatoid arthritis: a systematic review of effectiveness, safety and cost implications. ( Debroe, S; Hewitson, PJ; McBride, A; Milne, R, 2000) |
| "To evaluate the capacity of a pooled index of only the 3 patient self-report questionnaire measures among the 7 American College of Rheumatology (ACR) core data set (Core Data Set) measures to distinguish efficacy of active treatment of rheumatoid arthritis (RA) with leflunomide or methotrexate versus placebo in a randomized, controlled clinical trial, and to compare the results with those obtained using the ACR 20% response criteria (ACR20), Disease Activity Score (DAS), and other pooled indices." | 5.10 | An index of the three core data set patient questionnaire measures distinguishes efficacy of active treatment from that of placebo as effectively as the American College of Rheumatology 20% response criteria (ACR20) or the Disease Activity Score (DAS) in ( Amara, I; Cohen, S; Crawford, B; Felson, D; Koch, G; Pincus, T; Strand, V; Wolfe, F, 2003) |
| "To assess the effectiveness, safety and cost implications of leflunomide treatment for rheumatoid arthritis." | 4.80 | Leflunomide and rheumatoid arthritis: a systematic review of effectiveness, safety and cost implications. ( Debroe, S; Hewitson, PJ; McBride, A; Milne, R, 2000) |
| "Episcleritis and scleritis are relatively rare ocular diseases, which are commonly associated with rheumatic diseases including systemic lupus erythematosus (SLE)." | 1.43 | [Clinical characteristics of 4 cases of scleritis associated with systemic lupus erythematosus]. ( Jia, Y; Miao, H; Wang, L; Yang, Y; Zhang, XY; Zhou, YS, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, L | 1 |
| Yang, Y | 1 |
| Jia, Y | 1 |
| Miao, H | 1 |
| Zhou, YS | 1 |
| Zhang, XY | 1 |
| Pincus, T | 1 |
| Strand, V | 1 |
| Koch, G | 1 |
| Amara, I | 1 |
| Crawford, B | 1 |
| Wolfe, F | 1 |
| Cohen, S | 1 |
| Felson, D | 1 |
| Jakez-Ocampo, J | 1 |
| Richaud-Patin, Y | 1 |
| Granados, J | 1 |
| Sánchez-Guerrero, J | 1 |
| Llorente, L | 1 |
| Hewitson, PJ | 1 |
| Debroe, S | 1 |
| McBride, A | 1 |
| Milne, R | 1 |
| Hoshi, K | 1 |
| Hiida, M | 1 |
2 reviews available for leflunomide and Ache
| Article | Year |
|---|---|
Leflunomide and rheumatoid arthritis: a systematic review of effectiveness, safety and cost implications.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Cost | 2000 |
[Rheumatic pain].
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheum | 2001 |
1 trial available for leflunomide and Ache
| Article | Year |
|---|---|
An index of the three core data set patient questionnaire measures distinguishes efficacy of active treatment from that of placebo as effectively as the American College of Rheumatology 20% response criteria (ACR20) or the Disease Activity Score (DAS) in
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Health Status; Humans; Isoxazoles; | 2003 |
2 other studies available for leflunomide and Ache
| Article | Year |
|---|---|
[Clinical characteristics of 4 cases of scleritis associated with systemic lupus erythematosus].
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antinucle | 2016 |
Weekly leflunomide as monotherapy for recent-onset rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Administration Schedule; Female | 2004 |