leflunomide has been researched along with Abnormalities, Multiple in 1 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Abnormalities, Multiple: Congenital abnormalities that affect more than one organ or body structure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Leflunomide has inhibitory effects on dihydroorotate-dehydrogenase activity and protein tyrosine kinase activity." | 1.35 | Critical periods for the teratogenicity of immune-suppressant Leflunomide in mice. ( Fukushima, R; Hirashiba, M; Hishikawa, A; Kanamori, S; Kaneto, M; Kitagawa, H; Muranaka, R, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukushima, R | 1 |
| Kanamori, S | 1 |
| Hirashiba, M | 1 |
| Hishikawa, A | 1 |
| Muranaka, R | 1 |
| Kaneto, M | 1 |
| Kitagawa, H | 1 |
1 other study available for leflunomide and Abnormalities, Multiple
| Article | Year |
|---|---|
Critical periods for the teratogenicity of immune-suppressant Leflunomide in mice.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adjuvants, Immunologic; Animals; Critical Peri | 2009 |