leachianone-a has been researched along with Carcinoma--Hepatocellular* in 1 studies
1 other study(ies) available for leachianone-a and Carcinoma--Hepatocellular
| Article | Year |
|---|---|
Leachianone A as a potential anti-cancer drug by induction of apoptosis in human hepatoma HepG2 cells.
The Chinese herbal medicine Radix Sophorae is widely applied as an anti-carcinogenic/ anti-metastatic agent against liver cancer. In this study, Leachianone A, isolated from Radix Sophorae, possessed a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment. Its action mechanism via induction of apoptosis involved both extrinsic and intrinsic pathways. Its anti-tumor effect was further demonstrated in vivo by 17-54% reduction of tumor size in HepG2-bearing nude mice, in which no toxicity to the heart and liver tissues was observed. In conclusion, this is the first report describing the isolation of Leachianone A from Radix Sophorae and the molecular mechanism of its anti-proliferative effect on HepG2 cells. Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromones; DNA Fragmentation; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Proto-Oncogene Proteins c-bcl-2; Xenograft Model Antitumor Assays | 2007 |