lb-100 has been researched along with Lung-Neoplasms* in 1 studies
1 other study(ies) available for lb-100 and Lung-Neoplasms
Article | Year |
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Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer.
Protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of apoptosis, proliferation, and DNA-damage response, is overexpressed in many cancers, including small cell lung cancer (SCLC). Here we report that LB100, a small molecule inhibitor of PP2A, when combined with platinum-based chemotherapy, synergistically elicited an antitumor response both Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Piperazines; Protein Phosphatase 2; Small Cell Lung Carcinoma; Tumor Cells, Cultured | 2021 |