laulimalide and Adenocarcinoma

laulimalide has been researched along with Adenocarcinoma* in 2 studies

Reviews

1 review(s) available for laulimalide and Adenocarcinoma

Article	Year
Microtubule-stabilizing marine metabolite laulimalide and its derivatives: synthetic approaches and antitumor activity. Chemical reviews, 2003, Volume: 103, Issue:9 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Macrolides; Microtubules; Ovarian Neoplasms; Paclitaxel; Taxoids	2003

Other Studies

1 other study(ies) available for laulimalide and Adenocarcinoma

Article	Year
Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity. Cancer research, 2002, Jun-15, Volume: 62, Issue:12 Peloruside A is a novel secondary metabolite isolated from a New Zealand marine sponge, Mycale hentscheli, that has potent paclitaxel-like microtubule-stabilizing activity and is cytotoxic at nanomolar concentrations. Its 16-membered macrolide ring is similar to that of epothilone, a drug currently under clinical investigation as an anticancer agent. Like paclitaxel, peloruside A arrests cells in the G(2)-M phase of the cell cycle and induces apoptosis. The relatively simple structure of peloruside makes it suitable for the design and synthesis of analogues with improved tumor targeting and reduced tumor cross-resistance. Topics: Actins; Adenocarcinoma; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Epothilones; Humans; Lactones; Lung Neoplasms; Macrolides; Microtubules; Paclitaxel; Taxoids; Tubulin	2002

Article

Year

Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity.

Cancer research, 2002, Jun-15, Volume: 62, Issue:12

Peloruside A is a novel secondary metabolite isolated from a New Zealand marine sponge, Mycale hentscheli, that has potent paclitaxel-like microtubule-stabilizing activity and is cytotoxic at nanomolar concentrations. Its 16-membered macrolide ring is similar to that of epothilone, a drug currently under clinical investigation as an anticancer agent. Like paclitaxel, peloruside A arrests cells in the G(2)-M phase of the cell cycle and induces apoptosis. The relatively simple structure of peloruside makes it suitable for the design and synthesis of analogues with improved tumor targeting and reduced tumor cross-resistance.

Topics: Actins; Adenocarcinoma; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Epothilones; Humans; Lactones; Lung Neoplasms; Macrolides; Microtubules; Paclitaxel; Taxoids; Tubulin

2002