Page last updated: 2024-09-05

latrepirdine and Alzheimer Disease

latrepirdine has been researched along with Alzheimer Disease in 49 studies

Research

Studies (49)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	18 (36.73)	29.6817
2010's	29 (59.18)	24.3611
2020's	2 (4.08)	2.80

Authors

Authors	Studies
Hawker, DD; Jansen Labby, K; Mataka, JJ; Silverman, RB; Trippier, PC	1
Benhamú, B; López-Rodríguez, ML; Martín-Fontecha, M; Pardo, L; Vázquez-Villa, H	1
Ge, S; Guan, J; Lin, JP; Liu, XH; Wang, T; Wu, MB; Yang, LR	1
Baltrukevich, H; Czarnota, K; Handzlik, J; Kucwaj-Brysz, K	1
Bachurin, SO; Lermontova, NN; Nikolaeva, NS; Serkova, TP; Shevtsova, EF; Van'kin, GI; Vasilieva, NA	1
Chen, J; Feng, F; Gu, Y; Han, R; He, HJ; Wang, WW; Xie, C; Ye, Q	1
Bachurin, SO; Boltneva, NP; Dubova, LG; Kovaleva, NV; Makhaeva, GF; Rudakova, EV; Shevtsov, PN; Shevtsova, EF	1
Bachurin, SO; Brooks, S; Buchman, VL; Kotelevtsev, Y; Kozin, SA; Kukharsky, MS; Ninkina, N; Peters, OM; Shelkovnikova, T; Smith, GA; Springe, S; Tarasova, T	1
Andrisano, V; Bartolini, M; Bolognesi, ML; Hutter-Paier, B; Marco-Contelles, J; McClymont, DW; Mellor, IR; Monti, B; Rosini, M; Simoni, E; Soriano, E; Windisch, M	1
Cano-Cuenca, N; Jordán, J; Solís-García del Pozo, JE	1
Bates, KA; Bharadwaj, PR; Gandy, S; Groth, D; Martins, RN; Perry, G; Porter, T; Steele, JW; Teimouri, E; Verdile, G	1
Chau, S; Chen, JJ; Herrmann, N; Lanctôt, KL; Ruthirakuhan, MT	1
Burns, A; Jacoby, R	1
Aisen, PS; Bachurin, SO; Doody, RS; Gavrilova, SI; Hung, D; Sano, M; Seely, L; Thomas, RG	1
O'Brien, JT	1
Gura, T	1
Mackinnon, A	1
Burns, A	1
Williams, M	1
Liu, RT; Lü, QJ	1
Akiyama, H; Arai, T; Bachurin, SO; Buchman, VL; Goedert, M; Hasegawa, M; Kametani, F; Ninkina, N; Nonaka, T; Yamashita, M	1
Lebert, F; Pasquier, F	1
Kovács, T	1
Doody, RS	1
Ivachtchenko, AV; Kazey, V; Khvat, A; Mitkin, O; Okun, I; Tkachenko, SE	1
Sabbagh, MN; Shill, HA	1
Bonda, D; Perry, G; Smith, M; Su, B; Wang, X; Zhu, X	1
Rafii, MS	1
Miller, G	1
Gao, M; Hutchins, GD; Wang, M; Zheng, QH	1
Burns, A; Sachdeva, D	1
Shoji, M	1
Potter, PE	1
Sano, M	1
Bezprozvanny, I	1
Buccafusco, JJ; Lee, CH; Mohler, EG; Terry, AV; Webster, SJ; Wilson, CA	1
Gravitz, L	1
Hopkins, CR	1
Alfaro, IE; Barr, R; Bernales, S; Bharadwaj, P; Buxbaum, JD; Delgado, LM; Dolios, G; Ehrlich, ME; Fraser, P; Friss, A; Gandy, S; Glabe, CG; Gupta, V; Ju, S; Kim, SH; Lachenmayer, ML; Liken, J; Martins, RN; Petsko, GA; Protter, AA; Relkin, NR; Ringe, D; St George-Hyslop, PH; Steele, JW; Stock, A; Szabo, P; Verdile, G; Wang, R; Westaway, D; Yue, Z	1
Aksinenko, AY; Bachurin, SO; Buchman, VL; Connor-Robson, N; Kukharsky, MS; Ninkina, N; Peters, OM; Sokolov, VB	1
Gandy, S; Steele, JW	1
van Marum, RJ	1
Bachurin, SO; Lermontova, NN; Lukoyanov, NV; Lukoyanova, EA; Serkova, TP	1
Afanasiev, A; Bachurin, S; Bukatina, E; Grigoriev, V; Grigorieva, I; Ivanov, Y; Lermontova, N; Sablin, S; Tkachenko, S; Zefirov, N	1
Bachurin, SO; Kireeva, EG; Lermontova, NN; Redkozubov, AE; Serkova, TP; Shevtsova, EF	1

Reviews

21 review(s) available for latrepirdine and Alzheimer Disease

Article	Year
Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers. Journal of medicinal chemistry, 2013, Apr-25, Volume: 56, Issue:8 Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Antioxidants; Calcium Channels; Drug Combinations; Drug Design; Humans; Huntington Disease; Neurodegenerative Diseases; Nitric Oxide Synthase Type I; Oxidative Stress; Parkinson Disease; Protein Folding; Protein Structure, Quaternary; Proteostasis Deficiencies; Receptors, N-Methyl-D-Aspartate	2013
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease. Journal of medicinal chemistry, 2014, Sep-11, Volume: 57, Issue:17 Topics: Alzheimer Disease; Binding Sites; Clinical Trials as Topic; Cognition Disorders; Humans; Models, Molecular; Molecular Structure; Protein Structure, Tertiary; Receptors, Serotonin; Serotonin Antagonists	2014
Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease. European journal of medicinal chemistry, 2019, May-01, Volume: 169 Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Drug Discovery; Humans; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents	2019
Chemical update on the potential for serotonin 5-HT Bioorganic & medicinal chemistry letters, 2021, 10-01, Volume: 49 Topics: Alzheimer Disease; Animals; Humans; Nootropic Agents; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists	2021
Defective Autophagy and Mitophagy in Alzheimer's Disease: Mechanisms and Translational Implications. Molecular neurobiology, 2021, Volume: 58, Issue:10 Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Autophagy; Brain; Clinical Trials as Topic; Humans; Indoles; Mitochondria; Mitophagy; Neurofibrillary Tangles; Plaque, Amyloid; tau Proteins; Translational Science, Biomedical	2021
Evidence for the efficacy of latrepirdine (Dimebon) treatment for improvement of cognitive function: a meta-analysis. Journal of Alzheimer's disease : JAD, 2014, Volume: 38, Issue:1 Topics: Alzheimer Disease; Antipsychotic Agents; Cognition Disorders; Humans; Huntington Disease; Indoles; MEDLINE; Neuropsychological Tests; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Schizophrenia	2014
Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer's and other neurodegenerative diseases. Translational psychiatry, 2013, Dec-03, Volume: 3 Topics: Alzheimer Disease; Animals; Cognition; Humans; Huntington Disease; Indoles; Neurodegenerative Diseases; Neuroprotective Agents; Nootropic Agents	2013
Latrepirdine for Alzheimer's disease. The Cochrane database of systematic reviews, 2015, Apr-21, Issue:4 Topics: Alzheimer Disease; Behavior; Cognition; Humans; Indoles; Nootropic Agents; Randomized Controlled Trials as Topic	2015
Alzheimer's disease: on the verges of treatment and prevention. The Lancet. Neurology, 2009, Volume: 8, Issue:1 Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Histamine Antagonists; Humans; Indoles; Risk Factors	2009
[Progress in the research on multi-target-directed drugs against Alzheimer's disease]. Yao xue xue bao = Acta pharmaceutica Sinica, 2009, Volume: 44, Issue:3 Topics: Alzheimer Disease; Animals; Drug Combinations; Drug Delivery Systems; Drugs, Chinese Herbal; Humans; Indans; Indoles; Selective Estrogen Receptor Modulators; Tacrine; Thioctic Acid	2009
[Behavioral problems in Alzheimer disease: current and future treatments]. Revue neurologique, 2009, Volume: 165 Spec No 2 Topics: Alzheimer Disease; Exercise; Forecasting; Genotype; Humans; Indoles; Lithium Compounds; Mental Disorders	2009
[Therapy of Alzheimer disease]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2009, Volume: 11, Issue:1 Topics: Alzheimer Disease; Alzheimer Vaccines; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Cognition; Dopamine Agents; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Memantine; Neurofibrillary Tangles; Neuroprotective Agents; Nootropic Agents; Receptors, N-Methyl-D-Aspartate; Severity of Illness Index; tau Proteins	2009
Dimebon as a potential therapy for Alzheimer's disease. CNS spectrums, 2009, Volume: 14, Issue:8 Suppl 7 Topics: Alzheimer Disease; Histamine Antagonists; Humans; Indoles; Randomized Controlled Trials as Topic	2009
Latrepirdine, a potential novel treatment for Alzheimer's disease and Huntington's chorea. Current opinion in investigational drugs (London, England : 2000), 2010, Volume: 11, Issue:1 Topics: Alzheimer Disease; Animals; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Evaluation, Preclinical; Humans; Huntington Disease; Indoles; Nootropic Agents; Patents as Topic	2010
Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease? Molecular neurobiology, 2010, Volume: 41, Issue:2-3 Topics: Alzheimer Disease; Animals; Antioxidants; Apolipoprotein E4; Clinical Trials as Topic; Humans; Indoles; Mitochondria; Neurons; Presenilins; tau Proteins	2010
The pulse of drug development for Alzheimer's disease. Reviews on recent clinical trials, 2010, Volume: 5, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Antioxidants; Clinical Trials as Topic; Fatty Acids; Humans; Immunization, Passive; Indoles; Neuroprotective Agents; Neurotransmitter Agents; tau Proteins; Vaccination	2010
Dimebolin in dementia. CNS neuroscience & therapeutics, 2011, Volume: 17, Issue:3 Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Histamine H1 Antagonists; Humans; Indoles; Nootropic Agents; Randomized Controlled Trials as Topic	2011
[Drug therapy for Alzheimer's disease]. Brain and nerve = Shinkei kenkyu no shinpo, 2010, Volume: 62, Issue:7 Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Clioquinol; Drug Design; Excitatory Amino Acid Antagonists; Flurbiprofen; Indoles; Memantine; Meta-Analysis as Topic; Randomized Controlled Trials as Topic	2010
Investigational medications for treatment of patients with Alzheimer disease. The Journal of the American Osteopathic Association, 2010, Volume: 110, Issue:9 Suppl 8 Topics: Alzheimer Disease; Alzheimer Vaccines; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Cholinergic Agents; Drugs, Investigational; Etanercept; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoglobulin G; Indoles; Nicotinic Antagonists; Phosphodiesterase 5 Inhibitors; Receptors, Tumor Necrosis Factor; tau Proteins	2010
ACS chemical neuroscience molecule spotlight on dimebon. ACS chemical neuroscience, 2010, Sep-15, Volume: 1, Issue:9 Topics: Alzheimer Disease; Animals; Clinical Trials, Phase III as Topic; Humans; Indoles; Neurosciences; Societies, Scientific	2010
Current and future therapy in Alzheimer's disease. Fundamental & clinical pharmacology, 2008, Volume: 22, Issue:3 Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Docosahexaenoic Acids; Estrogen Replacement Therapy; Excitatory Amino Acid Antagonists; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunotherapy; Indoles; Memantine; Receptors, N-Methyl-D-Aspartate	2008

Trials

4 trial(s) available for latrepirdine and Alzheimer Disease

Article	Year
Dimebon in Alzheimer's disease: old drug for new indication. Lancet (London, England), 2008, Jul-19, Volume: 372, Issue:9634 Topics: Activities of Daily Living; Alzheimer Disease; Cognition; Double-Blind Method; Humans; Indoles; Russia; Treatment Outcome	2008
Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study. Lancet (London, England), 2008, Jul-19, Volume: 372, Issue:9634 Topics: Activities of Daily Living; Aged; Alzheimer Disease; Cognition; Double-Blind Method; Female; Humans; Indoles; Male; Middle Aged; Psychometrics; Russia; Severity of Illness Index; Treatment Outcome	2008
Molecule of the Month. Dimebolin hydrochloride. Drug news & perspectives, 2007, Volume: 20, Issue:7 Topics: Alzheimer Disease; Double-Blind Method; Humans; Huntington Disease; Indoles	2007
Antihistamine agent Dimebon as a novel neuroprotector and a cognition enhancer. Annals of the New York Academy of Sciences, 2001, Volume: 939 Topics: Aged; Alzheimer Disease; Animals; Calcium Channels; Cognition; Female; Humans; Indoles; Male; Memory; Mice; Middle Aged; Neurons; Neuroprotective Agents; Nootropic Agents; Pilot Projects; Rats; Receptors, N-Methyl-D-Aspartate	2001

Other Studies

24 other study(ies) available for latrepirdine and Alzheimer Disease

Article	Year
Wave-Like Dose-Dependence of the Stimulating Effects of Dimebon on Cognition in a Wide Dose Range. Bulletin of experimental biology and medicine, 2019, Volume: 167, Issue:6 Topics: Alzheimer Disease; Animals; Aziridines; Biological Clocks; Central Nervous System Stimulants; Choline; Cognition; Disease Models, Animal; Dose-Response Relationship, Drug; Indoles; Maze Learning; Mice; Mice, Inbred C57BL; Pattern Recognition, Physiological; Rats; Rats, Wistar	2019
Anticholinesterase and Antioxidant Activity of New Binary Conjugates of γ-Carbolines. Doklady. Biochemistry and biophysics, 2019, Volume: 484, Issue:1 Topics: Alzheimer Disease; Animals; Antioxidants; Carbolines; Cholinesterase Inhibitors; Indoles	2019
Chronic administration of Dimebon does not ameliorate amyloid-β pathology in 5xFAD transgenic mice. Journal of Alzheimer's disease : JAD, 2013, Volume: 36, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Brain; Disease Models, Animal; Indoles; Learning; Mice; Mice, Transgenic; Neurons; Rotarod Performance Test	2013
The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon. ChemMedChem, 2013, Volume: 8, Issue:8 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Binding Sites; Chickens; Cholinesterase Inhibitors; Humans; Indoles; Ligands; Molecular Docking Simulation; Neurons; Peptide Fragments; Protein Structure, Tertiary; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins	2013
A promising new treatment for Alzheimer's disease? The Lancet. Neurology, 2008, Volume: 7, Issue:9 Topics: Aged; Alzheimer Disease; Brain; Cholinesterase Inhibitors; Clinical Trials as Topic; Depressive Disorder; Humans; Indoles; Neuroprotective Agents; Placebo Effect; Receptors, N-Methyl-D-Aspartate; Treatment Outcome	2008
Hope in Alzheimer's fight emerges from unexpected places. Nature medicine, 2008, Volume: 14, Issue:9 Topics: Alzheimer Disease; Cognition; Humans; Indoles; Methylene Blue; Research	2008
Statistical treatment of withdrawal in trials of anti-dementia drugs. Lancet (London, England), 2008, Oct-18, Volume: 372, Issue:9647 Topics: Alzheimer Disease; Humans; Indoles; Outcome Assessment, Health Care; Patient Dropouts; Randomized Controlled Trials as Topic	2008
Progress in Alzheimer's disease drug discovery: an update. Current opinion in investigational drugs (London, England : 2000), 2009, Volume: 10, Issue:1 Topics: Alzheimer Disease; Amyloid; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Drug Industry; Enzyme Inhibitors; Humans; Indoles; Molecular Structure; tau Proteins	2009
New treatments in the pipeline for Alzheimer's. The Johns Hopkins medical letter health after 50, 2009, Volume: 21, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Indoles; Methylene Blue	2009
Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models. FEBS letters, 2009, Jul-21, Volume: 583, Issue:14 Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Cell Line; Dementia; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Inclusion Bodies; Indoles; Methylene Blue	2009
From anti-allergic to anti-Alzheimer's: Molecular pharmacology of Dimebon. Current Alzheimer research, 2010, Volume: 7, Issue:2 Topics: Alzheimer Disease; Animals; Brain; Brain Chemistry; Butyrylcholinesterase; Cell Line; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Drug Evaluation, Preclinical; Enzyme Inhibitors; Histamine Antagonists; Humans; Indoles; Nootropic Agents; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Histamine; Receptors, Neurotransmitter; Receptors, Serotonin	2010
Pharmacology. The puzzling rise and fall of a dark-horse Alzheimer's drug. Science (New York, N.Y.), 2010, Mar-12, Volume: 327, Issue:5971 Topics: Alzheimer Disease; Clinical Trials, Phase III as Topic; Drug Industry; Humans; Indoles	2010
[(11)C]Dimebon, radiosynthesis and lipophilicity of a new potential PET agent for imaging of Alzheimer's disease and Huntington's disease. Bioorganic & medicinal chemistry letters, 2010, Apr-15, Volume: 20, Issue:8 Topics: Alzheimer Disease; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Humans; Huntington Disease; Indoles; Positron-Emission Tomography	2010
Mechanism matters. Nature medicine, 2010, Volume: 16, Issue:4 Topics: Alzheimer Disease; Cognition; Drug Evaluation, Preclinical; Humans; Indoles; Nootropic Agents	2010
Learning from failure. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:7 Topics: Alzheimer Disease; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Databases, Bibliographic; Indoles; Nootropic Agents; Treatment Failure	2010
ICAD 2010: Detection may hold the key to treatment. International Conference on Alzheimer Disease (ICAD) 2010 Honolulu, HI, USA, 10–15 July 2010. Expert review of neurotherapeutics, 2010, Volume: 10, Issue:11 Topics: Alzheimer Disease; Dementia; Humans; Indoles	2010
The rise and fall of Dimebon. Drug news & perspectives, 2010, Volume: 23, Issue:8 Topics: Alzheimer Disease; Animals; Controlled Clinical Trials as Topic; Humans; Huntington Disease; Indoles; Product Recalls and Withdrawals; Receptors, Histamine H1; Receptors, Serotonin; Russia; Treatment Failure	2010
The acute effects of dimebolin, a potential Alzheimer's disease treatment, on working memory in rhesus monkeys. British journal of pharmacology, 2011, Volume: 164, Issue:3 Topics: Age Factors; Alzheimer Disease; Animals; Cognition Disorders; Female; Indoles; Macaca mulatta; Male; Memory, Short-Term; Psychomotor Performance; Scopolamine	2011
Drugs: a tangled web of targets. Nature, 2011, Jul-13, Volume: 475, Issue:7355 Topics: Alanine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Azepines; Clinical Trials as Topic; Disease Progression; Genetic Therapy; Glycogen Synthase Kinase 3; Humans; Indoles; Memantine; Methylene Blue; Molecular Targeted Therapy; Nerve Growth Factor; Neurofibrillary Tangles; Phosphorylation; tau Proteins	2011
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular psychiatry, 2013, Volume: 18, Issue:8 Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Autophagy; Autophagy-Related Protein 5; Brain; Cells, Cultured; Cognition; Dose-Response Relationship, Drug; Indoles; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Neuroprotective Agents; Peptide Fragments; Signal Transduction; TOR Serine-Threonine Kinases	2013
Chronic administration of dimebon ameliorates pathology in TauP301S transgenic mice. Journal of Alzheimer's disease : JAD, 2013, Volume: 33, Issue:4 Topics: Alzheimer Disease; Animals; Drug Administration Schedule; Indoles; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; tau Proteins; Tauopathies	2013
Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model. Autophagy, 2013, Volume: 9, Issue:4 Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Autophagy; Disease Models, Animal; Humans; Indoles; Mice; Mice, Transgenic; Neurons	2013
Dimebon improves learning in animals with experimental Alzheimer's disease. Bulletin of experimental biology and medicine, 2000, Volume: 129, Issue:6 Topics: Alzheimer Disease; Animals; Avoidance Learning; Aziridines; Choline; Cholinesterase Inhibitors; Disease Models, Animal; Histamine H1 Antagonists; Indoles; Injections, Intraventricular; Male; Neuromuscular Blocking Agents; Rats; Rats, Wistar; Tacrine	2000
Dimebon and tacrine inhibit neurotoxic action of beta-amyloid in culture and block L-type Ca(2+) channels. Bulletin of experimental biology and medicine, 2001, Volume: 132, Issue:5 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Calcium; Calcium Channels, L-Type; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Indoles; Neurons; Neuroprotective Agents; Parasympathomimetics; Rats; Tacrine; Temperature; Time Factors	2001