latanoprost and Choroid-Diseases

Topics: Acetazolamide; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Benzophenones; Bromobenzenes; Carbonic Anhydrase Inhibitors; Choroid; Choroid Diseases; Ciliary Body; Drug Therapy, Combination; Fluorescein Angiography; Fundus Oculi; Humans; Latanoprost; Male; Microphthalmos; Middle Aged; Retina; Retinal Detachment; Syndrome; Tomography, Optical Coherence; Uveal Diseases

Topical latanoprost is a most effective and commonly used antiglaucoma medication. Use of prostaglandin analogues (PGA) in the early postoperative period is controversial due to its proinflammatory properties. We report a case of a 64-year-old man with primary open angle glaucoma, post-trabeculectomy 17 years prior, with good intraocular pressure (IOP) control on topical levobunolol 0.5% and latanoprost 0.005%. He underwent a clear corneal phacoemulsification surgery in his left eye and the PGA was stopped. He had an uneventful postoperative course and was prescribed eyeglasses at 4-week follow-up. Two weeks later, he presented to the emergency department with decreased vision in the left eye, flat anterior chamber, IOP of 00 mm Hg and 360° choroidal detachment. The continued use of topical latanoprost in the operated eye was implicated as the cause. This case illustrates the serious vision-threatening side effect of PGA when used in the early postoperative period.

Topics: Administration, Topical; Anterior Chamber; Antihypertensive Agents; Cataract; Cataract Extraction; Choroid; Choroid Diseases; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Lens Implantation, Intraocular; Male; Medication Errors; Middle Aged; Ocular Hypotension; Phacoemulsification; Postoperative Care; Postoperative Complications; Prostaglandins F, Synthetic; Tonometry, Ocular; Trabeculectomy; Visual Acuity

To report a case series of three patients with bilateral uveal effusion syndrome (UES), treated conservatively with oral carbonic anhydrase inhibitors and topical prostaglandin analogues (PAs).. Three patients with bilateral UES were treated with the same initial therapy. Topical PA latanoprost 0.005% and acetazolamide 250 mg were administered in order to reduce intraocular pressure, improve uveoscleral outflow, and facilitate resolution of uveal effusion.. The chorioretinal detachment resolved within 3 months in two reported patients while the third one underwent surgery on his left eye. After clinical improvement, further oral therapy with acetazolamide was stopped, while topical prostaglandins were continued for at least the next 3 months. All patients were free from recurrence during the follow-up period.. Although the usually recommended UES therapy is partial or full-thickness sclerectomy, our case series showed apparent resolution of chorioretinal detachment in two patients on medical therapy alone. Conservative therapy may be the first step before the standard recommended surgical approach, but further studies are needed to verify the effectiveness of reported therapy.

Topics: Acetazolamide; Administration, Oral; Administration, Topical; Adult; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Choroid Diseases; Drug Therapy, Combination; Female; Humans; Intraocular Pressure; Latanoprost; Magnetic Resonance Imaging; Male; Middle Aged; Prostaglandins F, Synthetic; Retinal Detachment; Uveal Diseases

Topics: Aged, 80 and over; Choroid; Choroid Diseases; Eye; Female; Humans; Latanoprost; Prostaglandins F, Synthetic

Hypotony with choroidal detachment is a rare complication of glaucoma medication. In this study, we report on a case which supports the hypothesis that has been proposed to explain this phenomenon.. This study was designed as an observational case report.. A woman with chronic glaucoma underwent trabeculectomy on both eyes. Low intraocular pressure (IOP) developed in 1 eye only, with no visual change for many years. After cataract surgery, the IOP increased, necessitating treatment with topical timolol 0.5% and dorzolamide 2%. She developed monocular hypotony and choroidal detachment 3 months later. This complication occurred in the eye that had previously had a low IOP and resolved completely when topical medication was stopped. The choroidal detachment recurred when rechallenged with the same medication.. Topical aqueous suppression therapy can result in hypotony and choroidal detachment in an eye in which relatively low IOP has been maintained for many years after glaucoma filtration surgery. The problem resolves on stopping the medication.

Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Cataract Extraction; Choroid Diseases; Chronic Disease; Drug Interactions; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Middle Aged; Ocular Hypotension; Ophthalmic Solutions; Prostaglandins F, Synthetic; Recurrence; Sulfonamides; Thiophenes; Timolol; Trabeculectomy

To report three cases of delayed choroidal detachment after treatment with topical prostaglandin analogs.. Intervention three case reports. Four eyes of three patients with chronic angle closure glaucoma developed choroidal detachment after using topical prostaglandin analogs.. Three patients with chronic angle closure glaucoma developed chroidal detachment in one week, three weeks and two years after using travoprost, bimatoprost and latanoprost respectively. All of them resolved after discontinuation of these medications. All of the eyes that developed chroidal detachment were pseudophakic.. Travoprost, bimatoprost and latanoprost may lead to choroidal detachment and hypotony. Pseudophakic patients may be at high risk of the development of chroidal detachment. Topical prostaglandin analogs should be used cautiously in these patients.

Topics: Administration, Topical; Aged; Amides; Bimatoprost; Choroid Diseases; Cloprostenol; Female; Glaucoma, Angle-Closure; Humans; Latanoprost; Lipids; Middle Aged; Ocular Hypotension; Prostaglandins F, Synthetic; Prostaglandins, Synthetic; Risk Factors; Time Factors; Travoprost

Topics: Adult; Antihypertensive Agents; Choroid Diseases; Humans; Intraocular Pressure; Latanoprost; Male; Postoperative Complications; Prostaglandins F, Synthetic; Trabeculectomy

Choroidal effusion and anterior chamber loss can occur in a trabeculectomized eye either spontaneously or following aqueous suppressant drug use.. A 50 year-old women with complaints of pain in the left eye (LE) was diagnosed as angle closure glaucoma. She was treated medically and underwent bilateral laser iridotomy. Because of high intraocular pressure it was decided to perform trabeculectomy. During the follow up period, the bleb became flat and after 3 months the IOP was again 24 mmHg with timolol maleate 0.5% and dorzolamide twice a day. Latanoprost was added to the therapy of the LE.. 12 days later the patient returned with pain and vision loss in her LE. The anterior chamber was diffusely narrow and ophthalmoscopy showed massive choroidal effusion.. The possible mechanisms of this complication were discussed.

Topics: Anterior Chamber; Antihypertensive Agents; Choroid Diseases; Exudates and Transudates; Female; Glaucoma, Angle-Closure; Glucocorticoids; Humans; Intraocular Pressure; Iridectomy; Laser Therapy; Latanoprost; Middle Aged; Mydriatics; Prostaglandins F, Synthetic; Trabeculectomy; Treatment Outcome; Visual Acuity

Topics: Aged; Antihypertensive Agents; Cataract Extraction; Choroid Diseases; Glaucoma, Open-Angle; Humans; Latanoprost; Male; Prostaglandins F, Synthetic; Retinal Detachment

To report a case of delayed choroidal detachment after treatment with topical latanoprost.. Interventional case report. Five years after trabeculectomy in a 91-year-old female, a Holmium laser thermal sclerostomy was performed, and a year later, the patient was started on latanoprost.005% every 24 hours and hydrochloride dorzolamide 2% three times daily.. Choroidal detachments developed 2.5 years after the sclerostomy; they resolved after discontinuation of the latanoprost and hydrochloride dorzolamide. Subsequently, the patient inadvertently restarted latanoprost. Again, the latanoprost was stopped, with resolution of the choroidal detachments.. Topical latanoprost may lead to choroidal detachments and hypotony.

Topics: Administration, Topical; Aged; Aged, 80 and over; Antihypertensive Agents; Choroid Diseases; Female; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Ophthalmic Solutions; Prostaglandins F, Synthetic; Sclerostomy; Trabeculectomy

Topics: Aged; Anti-Inflammatory Agents; Antihypertensive Agents; Choroid Diseases; Glaucoma, Open-Angle; Humans; Latanoprost; Male; Phacoemulsification; Prednisolone; Prostaglandins F, Synthetic; Retinal Detachment; Treatment Outcome

To report three different adverse reactions after initiating treatment with latanoprost.. Serial clinical examinations of three patients were performed.. Adverse reactions such as ocular hypotony and choroidal effusions, recurrent cystoid macular edema, and facial rash were noted to occur within 1 to 4 weeks after starting topical latanoprost for the treatment of primary open-angle glaucoma.. Clinicians should be alerted to these possible complications of topical latanoprost therapy.

Topics: Aged; Aged, 80 and over; Choroid Diseases; Exanthema; Female; Fluorescein Angiography; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Macular Edema; Male; Ocular Hypotension; Ophthalmic Solutions; Prostaglandins F, Synthetic; Recurrence