lassbio-294 and Disease-Models--Animal

We described herein the molecular design of novel in vivo anti-inflammatory 6-methanesulfonamide-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives (1) planned by applying the molecular hybridization approach. This work also points out to the discovery of LASSBio-930 (1c) as a novel anti-inflammatory and anti-hyperalgesic prototype, which was able to reduce carrageenan-induced rat paw edema with an ED(50) of 97.8 micromol/kg, acting mainly as a non-selective COX inhibitor.

Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodioxoles; Carrageenan; Computer Simulation; Crystallography, X-Ray; Cyclooxygenase Inhibitors; Disease Models, Animal; Edema; Female; Hydrazones; Male; Rats; Rats, Wistar; Thermodynamics