lasiocarpine and Neoplasms

lasiocarpine has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for lasiocarpine and Neoplasms

Article	Year
Malignant neoplasms in rats fed lasiocarpine. British journal of cancer, 1978, Volume: 37, Issue:2 Lasiocarpine, a pyrrolizidine alkaloid, was fed at a dietary concentration of 50/10(6) for 55 weeks, to 20 male F-344 rats. Malignant tumours developed in 17/20 animals between 48 and 59 weeks. Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinomas. Other tumours included malignant adnexas tumour of the skin (1 rat) and lympohoma (1 rat). Lung metastases were observed in 4 animals with angiosarcoma of the liver and one animal with hepatocellular carcinoma. From one animal, angiosarcoma was successfully transplanted through 4 generations. Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Hemangiosarcoma; Liver Neoplasms; Male; Neoplasms; Plants, Toxic; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344; Senecio	1978

Article

Year

Malignant neoplasms in rats fed lasiocarpine.

British journal of cancer, 1978, Volume: 37, Issue:2

Lasiocarpine, a pyrrolizidine alkaloid, was fed at a dietary concentration of 50/10(6) for 55 weeks, to 20 male F-344 rats. Malignant tumours developed in 17/20 animals between 48 and 59 weeks. Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinomas. Other tumours included malignant adnexas tumour of the skin (1 rat) and lympohoma (1 rat). Lung metastases were observed in 4 animals with angiosarcoma of the liver and one animal with hepatocellular carcinoma. From one animal, angiosarcoma was successfully transplanted through 4 generations.

Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Hemangiosarcoma; Liver Neoplasms; Male; Neoplasms; Plants, Toxic; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344; Senecio

1978