lasalocid and Uremia

Six adult sheep were fed at maintenance level, successively over three experimental periods, 1100 g of a roughage-rich diet without supplement or containing 33 mg kg-1 of lasalocid or cationomycin. The feed was administered in eight equal meals daily, every three hours. Blood samples were taken in each animal from the jugular vein at 10.00 hours, 16.00 and 22.00 hours, one hour after the animals were fed. The ionophores did not affect the plasma concentrations of glucose, free fatty acids, total amino acids, insulin, acetate, Ca or Mg. They decreased beta-hydroxy butyrate content (P < 0.05) and increased that of albumin (P < 0.05). Lasalocid alone significantly decreased uremia, but the significant threshold was only reached at 16.00 hours (P < 0.01). With this exception, the two ionophores had similar effects. Samples taken in peripheral blood appear to be too far from nutrient absorption sites to give a clear indication of the effects of these molecules on the products absorbed or metabolised in the digestive tract.

Topics: 3-Hydroxybutyric Acid; Animal Feed; Animals; Anti-Bacterial Agents; Complement C2; Food, Fortified; Furans; Hydroxybutyrates; Ionophores; Lasalocid; Serum Albumin; Sheep; Urea; Uremia